Effects of levetiracetam on axon excitability and synaptic transmission at the crayfish neuromuscular junction

Synapse ◽  
2020 ◽  
Vol 74 (8) ◽  
Author(s):  
Shaikhah Alshuaib ◽  
Julie Mosaddeghi ◽  
Jen‐We Lin
Keyword(s):  
Neuromuscular Junction ◽  
Synaptic Transmission ◽  
Crayfish Neuromuscular Junction

Long-term facilitation of synaptic transmission demonstrated with macro-patch recording at the crayfish neuromuscular junction

1988 ◽  
Vol 90 (1-2) ◽  
pp. 152-158 ◽  
Author(s):  
J.M. Wojtowicz ◽  
I. Parnas ◽  
H. Parnas ◽  
H.L. Atwood
Keyword(s):  
Neuromuscular Junction ◽  
Synaptic Transmission ◽  
Long Term Facilitation ◽  
Crayfish Neuromuscular Junction

Similar oxysterols may lead to opposite effects on synaptic transmission: Olesoxime versus 5α-cholestan-3-one at the frog neuromuscular junction

2016 ◽  
Vol 1861 (7) ◽  
pp. 606-616 ◽  
Author(s):  
M.R. Kasimov ◽  
G.F. Zakyrjanova ◽  
A.R. Giniatullin ◽  
A.L. Zefirov ◽  
A.M. Petrov
Keyword(s):  
Neuromuscular Junction ◽  
Synaptic Transmission ◽  
Frog Neuromuscular Junction

scholarly journals The effect of dimorpholamine on crayfish neuromuscular junction

1970 ◽  
Vol 66 (3) ◽  
pp. 293-303
Author(s):  
Tetsuji HIRONAKA
Keyword(s):  
Neuromuscular Junction ◽  
Crayfish Neuromuscular Junction

Long-term facilitation alters transmitter releasing properties at the crayfish neuromuscular junction

1986 ◽  
Vol 55 (3) ◽  
pp. 484-498 ◽  
Author(s):  
J. M. Wojtowicz ◽  
H. L. Atwood
Keyword(s):  
Neuromuscular Junction ◽  
Synaptic Transmission ◽  
Time Course ◽  
Muscle Fibers ◽  
Low Frequencies ◽  
Before And After ◽  
Binomial Parameter ◽  
Small Muscle ◽  
Long Term Facilitation

Synaptic transmission at the neuromuscular junction of the excitatory axon supplying the crayfish opener muscle was examined before and after induction of long-term facilitation (LTF) by a 10-min period of stimulation at 20 Hz. Induction of LTF led to a period of enhanced synaptic transmission, which often persisted for many hours. The enhancement was entirely presynaptic in origin, since quantal unit size and time course were not altered, and quantal content of transmission (m) was increased. LTF was not associated with any persistent changes in action potential or presynaptic membrane potential recorded in the terminal region of the excitatory axon. The small muscle fibers of the walking-leg opener muscle were almost isopotential, and all quantal events could be recorded with an intracellular microelectrode. In addition, at low frequencies of stimulation, m was small. Thus it was possible to apply a binomial model of transmitter release to events recorded from individual muscle fibers and to calculate values for n (number of responding units involved in transmission) and p (probability of transmission for the population of responding units) before and after LTF. In the majority of preparations analyzed (6/10), amplitude histograms of evoked synaptic potentials could be described by a binomial distribution with a small n and moderately high p. LTF produced a significant increase in n, while p was slightly reduced. The results can be explained by a model in which the binomial parameter n represents the number of active synapses and parameter p the mean probability of release at a synapse. Provided that a pool of initially inactive synapses exists, one can postulate that LTF involves recruitment of synapses to the active state.

Sign in / Sign up

Export Citation Format

Share Document