scholarly journals COVID ‐19 vaccination uptake in people with severe mental illness: a UK ‐based cohort study

2022 ◽  
Vol 21 (1) ◽  
pp. 153-154
Author(s):  
Lamiece Hassan ◽  
Chelsea Sawyer ◽  
Niels Peek ◽  
Karina Lovell ◽  
Andre F. Carvalho ◽  
...  
2020 ◽  
Vol 35 (9) ◽  
pp. 879-889
Author(s):  
Cemre Su Osam ◽  
Matthias Pierce ◽  
Holly Hope ◽  
Darren M. Ashcroft ◽  
Kathryn M. Abel

Abstract Reduced vaccination uptake is a growing and global public health concern. There is limited knowledge about the effect of maternal mental illness (MMI) on rates of childhood vaccination. This retrospective cohort study examined 479,949 mother-baby pairs born between 1993 and 2015 in the Clinical Practice Research Datalink (CPRD GOLD), a UK-based, primary health-care database. The influence of MMI on children’s vaccination status at two and five years of age was investigated using logistic regression adjusting for sex of the child, child ethnicity, delivery year, maternal age, practice level deprivation quintile and region. The vaccinations were: 5-in-1 (DTaP/IPV/Hib) and first dose MMR by the age of two; and all three doses of 5-in-1, first and second dose of MMR vaccines by the age of five. Exposure to MMI was defined using recorded clinical events for: depression, anxiety, psychosis, eating disorder, personality disorder and alcohol and substance misuse disorders. The likelihood that a child completed their recommended vaccinations by the age of two and five was significantly lower among children with MMI compared to children with mothers without mental illness [adjusted odds ratio (aOR) 0.86, 95% CI 0.84–0.88, p < 0.001]. The strongest effect was observed for children exposed to maternal alcohol or substance misuse (at two years aOR 0.50, 95% CI 0.44–0.58, p < 0.001). In the UK, an estimated five thousand more children per year would be vaccinated if children with MMI had the same vaccination rates as children with well mothers. Maternal mental illness is a hitherto largely unrecognised reason that children may be missing vital vaccinations at two and five years of age. This risk is highest for those children living with maternal alcohol or substance misuse.


2018 ◽  
Vol 69 (1) ◽  
pp. 48-54 ◽  
Author(s):  
Melanie Thomas ◽  
Monique James ◽  
Eric Vittinghoff ◽  
Jennifer M. Creasman ◽  
Dean Schillinger ◽  
...  

2015 ◽  
Vol 2 (12) ◽  
pp. 1084-1091 ◽  
Author(s):  
Siân Oram ◽  
Mizanur Khondoker ◽  
Melanie Abas ◽  
Matthew Broadbent ◽  
Louise M Howard

2017 ◽  
Vol 4 (5) ◽  
pp. 389-399 ◽  
Author(s):  
Jayati Das-Munshi ◽  
Chin-Kuo Chang ◽  
Rina Dutta ◽  
Craig Morgan ◽  
James Nazroo ◽  
...  

2021 ◽  
pp. 1-8
Author(s):  
Kelly Fleetwood ◽  
Sarah H. Wild ◽  
Daniel J. Smith ◽  
Stewart W. Mercer ◽  
Kirsty Licence ◽  
...  

Background Severe mental illness (SMI) is associated with increased stroke risk, but little is known about how SMI relates to stroke prognosis and receipt of acute care. Aims To determine the association between SMI and stroke outcomes and receipt of process-of-care quality indicators (such as timely admission to stroke unit). Method We conducted a cohort study using routinely collected linked data-sets, including adults with a first hospital admission for stroke in Scotland during 1991–2014, with process-of-care quality indicator data available from 2010. We identified pre-existing schizophrenia, bipolar disorder and major depression from hospital records. We used logistic regression to evaluate 30-day, 1-year and 5-year mortality and receipt of process-of-care quality indicators by pre-existing SMI, adjusting for sociodemographic and clinical factors. We used Cox regression to evaluate further stroke and vascular events (stroke and myocardial infarction). Results Among 228 699 patients who had had a stroke, 1186 (0.5%), 859 (0.4%), 7308 (3.2%) had schizophrenia, bipolar disorder and major depression, respectively. Overall, median follow-up was 2.6 years. Compared with adults without a record of mental illness, 30-day mortality was higher for schizophrenia (adjusted odds ratio (aOR) = 1.33, 95% CI 1.16–1.52), bipolar disorder (aOR = 1.37, 95% CI 1.18–1.60) and major depression (aOR = 1.11, 95% CI 1.05–1.18). Each disorder was also associated with marked increased risk of 1-year and 5-year mortality and further stroke and vascular events. There were no clear differences in receipt of process-of-care quality indicators. Conclusions Pre-existing SMI was associated with higher risks of mortality and further vascular events. Urgent action is needed to better understand and address the reasons for these disparities.


Author(s):  
Guillaume Fond ◽  
Vanessa Pauly ◽  
Marc Leone ◽  
Pierre-Michel Llorca ◽  
Veronica Orleans ◽  
...  

Abstract Patients with schizophrenia (SCZ) represent a vulnerable population who have been understudied in COVID-19 research. We aimed to establish whether health outcomes and care differed between patients with SCZ and patients without a diagnosis of severe mental illness. We conducted a population-based cohort study of all patients with identified COVID-19 and respiratory symptoms who were hospitalized in France between February and June 2020. Cases were patients who had a diagnosis of SCZ. Controls were patients who did not have a diagnosis of severe mental illness. The outcomes were in-hospital mortality and intensive care unit (ICU) admission. A total of 50 750 patients were included, of whom 823 were SCZ patients (1.6%). The SCZ patients had an increased in-hospital mortality (25.6% vs 21.7%; adjusted OR 1.30 [95% CI, 1.08–1.56], P = .0093) and a decreased ICU admission rate (23.7% vs 28.4%; adjusted OR, 0.75 [95% CI, 0.62–0.91], P = .0062) compared with controls. Significant interactions between SCZ and age for mortality and ICU admission were observed (P = .0006 and P &lt; .0001). SCZ patients between 65 and 80 years had a significantly higher risk of death than controls of the same age (+7.89%). SCZ patients younger than 55 years had more ICU admissions (+13.93%) and SCZ patients between 65 and 80 years and older than 80 years had less ICU admissions than controls of the same age (−15.44% and −5.93%, respectively). Our findings report the existence of disparities in health and health care between SCZ patients and patients without a diagnosis of severe mental illness. These disparities differed according to the age and clinical profile of SCZ patients, suggesting the importance of personalized COVID-19 clinical management and health care strategies before, during, and after hospitalization for reducing health disparities in this vulnerable population.


2015 ◽  
Vol 172 (8) ◽  
pp. 776-783 ◽  
Author(s):  
Anette Riisgaard Ribe ◽  
Mogens Vestergaard ◽  
Wayne Katon ◽  
Morten Charles ◽  
Michael Eriksen Benros ◽  
...  

2014 ◽  
Vol 277 (6) ◽  
pp. 727-736 ◽  
Author(s):  
R. Bodén ◽  
E. Molin ◽  
T. Jernberg ◽  
H. Kieler ◽  
B. Lindahl ◽  
...  

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