Quorum Sensing: A Cell-Cell Signalling Mechanism Used to Coordinate Behavioral Changes in Bacterial Populations

2006 ◽  
pp. 42-48 ◽  
Author(s):  
Miguel Cámara
Keyword(s):  
Quorum Sensing ◽  
Cell Signalling ◽  
Behavioral Changes ◽  
Bacterial Populations ◽  
A Cell ◽  
Cell Cell

Quorum Sensing: Bacterial Cell-Cell Signalling from Bioluminescence to Pathogenicity

1998 ◽  
pp. 185-207 ◽  
Author(s):  
Simon Swift ◽  
John Throup ◽  
Barrie Bycroft ◽  
Paul Williams ◽  
Gordon Stewart
Keyword(s):  
Quorum Sensing ◽  
Bacterial Cell ◽  
Cell Signalling ◽  
Cell Cell

scholarly journals Erratum: A cell-cell communication signal integrates quorum sensing and stress response

2013 ◽  
Vol 9 (6) ◽  
pp. 406-406
Author(s):  
Jasmine Lee ◽  
Jien Wu ◽  
Yinyue Deng ◽  
Jing Wang ◽  
Chao Wang ◽  
...  
Keyword(s):  
Stress Response ◽  
Quorum Sensing ◽  
Cell Communication ◽  
Communication Signal ◽  
A Cell ◽  
Cell Cell

scholarly journals Bacterial Quorum Sensing and Microbial Community Interactions

mBio ◽  
2018 ◽  
Vol 9 (3) ◽  
Author(s):  
Rhea G. Abisado ◽  
Saida Benomar ◽  
Jennifer R. Klaus ◽  
Ajai A. Dandekar ◽  
Josephine R. Chandler
Keyword(s):  
Quorum Sensing ◽  
Bacterial Infections ◽  
Molecular Mechanisms ◽  
Cell Communication ◽  
Microbial Interactions ◽  
Community Interactions ◽  
Bacterial Populations ◽  
Bacterial Quorum Sensing ◽  
A Cell ◽  
Bacterial Quorum

ABSTRACTMany bacteria use a cell-cell communication system called quorum sensing to coordinate population density-dependent changes in behavior. Quorum sensing involves production of and response to diffusible or secreted signals, which can vary substantially across different types of bacteria. In many species, quorum sensing modulates virulence functions and is important for pathogenesis. Over the past half-century, there has been a significant accumulation of knowledge of the molecular mechanisms, signal structures, gene regulons, and behavioral responses associated with quorum-sensing systems in diverse bacteria. More recent studies have focused on understanding quorum sensing in the context of bacterial sociality. Studies of the role of quorum sensing in cooperative and competitive microbial interactions have revealed how quorum sensing coordinates interactions both within a species and between species. Such studies of quorum sensing as a social behavior have relied on the development of “synthetic ecological” models that use nonclonal bacterial populations. In this review, we discuss some of these models and recent advances in understanding how microbes might interact with one another using quorum sensing. The knowledge gained from these lines of investigation has the potential to guide studies of microbial sociality in natural settings and the design of new medicines and therapies to treat bacterial infections.

Production of the signalling molecule, autoinducer-2, by Neisseria meningitidis: lack of evidence for a concerted transcriptional response

Microbiology ◽  
2003 ◽  
Vol 149 (7) ◽  
pp. 1859-1869 ◽  
Author(s):  
Joanne E. Dove ◽  
Kazutoyo Yasukawa ◽  
Colin R. Tinsley ◽  
Xavier Nassif
Keyword(s):  
Quorum Sensing ◽  
Neisseria Meningitidis ◽  
Dna Microarrays ◽  
Transcriptional Profiling ◽  
Cell Signalling ◽  
Transcriptional Response ◽  
Autoinducer 2 ◽  
Signalling Molecule ◽  
A Cell ◽  
Quorum Sensing Molecule

Neisseria meningitidis is a Gram-negative bacterium which is an important causative agent of septicaemia and meningitis. LuxS has been shown to be involved in the biosynthesis of a quorum sensing molecule, autoinducer-2 (AI-2), known to play a role in virulence in Escherichia coli, as well as other bacteria. Evidence that serogroup B of N. meningitidis produces AI-2, along with the observation that a luxS mutant of this strain had attenuated virulence in an infant rat model of bacteraemia, led to further investigation of the role of this quorum sensing molecule in N. meningitidis. In this study, it is demonstrated that AI-2 is not involved in regulating growth of meningococci, either in culture or in contact with epithelial cells. Furthermore, transcriptional profiling using DNA microarrays shows an absence of the concerted regulation seen in other bacteria. Taken together, these data suggest that in N. meningitidis, AI-2 may be a metabolic by-product and not a cell-to-cell signalling molecule.

scholarly journals Pseudomonas aeruginosa Las quorum sensing autoinducer suppresses growth and biofilm production in Legionella species

Microbiology ◽  
2009 ◽  
Vol 155 (6) ◽  
pp. 1934-1939 ◽  
Author(s):  
Soichiro Kimura ◽  
Kazuhiro Tateda ◽  
Yoshikazu Ishii ◽  
Manabu Horikawa ◽  
Shinichi Miyairi ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Quorum Sensing ◽  
Legionella Pneumophila ◽  
Bacterial Species ◽  
Cell Signalling ◽  
Homoserine Lactone ◽  
Alcaligenes Faecalis ◽  
Suppressive Effect ◽  
Dependent Manner ◽  
A Cell

Bacteria commonly communicate with each other by a cell-to-cell signalling mechanism known as quorum sensing (QS). Recent studies have shown that the Las QS autoinducer N-(3-oxododecanoyl)-l-homoserine lactone (3-oxo-C12-HSL) of Pseudomonas aeruginosa performs a variety of functions not only in intraspecies communication, but also in interspecies and interkingdom interactions. In this study, we report the effects of Pseudomonas 3-oxo-C12-HSL on the growth and suppression of virulence factors in other bacterial species that frequently co-exist with Ps. aeruginosa in nature. It was found that 3-oxo-C12-HSL, but not its analogues, suppressed the growth of Legionella pneumophila in a dose-dependent manner. However, 3-oxo-C12-HSL did not exhibit a growth-suppressive effect on Serratia marcescens, Proteus mirabilis, Escherichia coli, Alcaligenes faecalis and Stenotrophomonas maltophilia. A concentration of 50 μM 3-oxo-C12-HSL completely inhibited the growth of L. pneumophila. Additionally, a significant suppression of biofilm formation was demonstrated in L. pneumophila exposed to 3-oxo-C12-HSL. Our results suggest that the Pseudomonas QS autoinducer 3-oxo-C12-HSL exerts both bacteriostatic and virulence factor-suppressive activities on L. pneumophila alone.

A cell-cell communication signal integrates quorum sensing and stress response

2013 ◽  
Vol 9 (5) ◽  
pp. 339-343 ◽  
Author(s):  
Jasmine Lee ◽  
Jien Wu ◽  
Yinyue Deng ◽  
Jing Wang ◽  
Chao Wang ◽  
...  
Keyword(s):  
Stress Response ◽  
Quorum Sensing ◽  
Cell Communication ◽  
Communication Signal ◽  
A Cell ◽  
Cell Cell
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