Preparation of the Multifunctional Liposome-Containing Microneedle Arrays as an Oral Cavity Mucosal Vaccine Adjuvant-Delivery System

2016 ◽  
pp. 651-667 ◽  
Author(s):  
Ting Wang ◽  
Ning Wang
Keyword(s):  
Oral Cavity ◽  
Delivery System ◽  
Mucosal Vaccine ◽  
Vaccine Adjuvant ◽  
Microneedle Arrays

Archaeal lipid mucosal vaccine adjuvant and delivery system

2010 ◽  
Vol 9 (4) ◽  
pp. 431-440 ◽  
Author(s):  
Girishchandra B Patel ◽  
Wangxue Chen
Keyword(s):  
Delivery System ◽  
Mucosal Vaccine ◽  
Vaccine Adjuvant

Microneedle arrays fabricated with the aluminum-based cochleates as an effective vaginal vaccine adjuvant-delivery system (VADS)

2018 ◽  
Vol 14 (5) ◽  
pp. 1745
Author(s):  
Ning Wang ◽  
Xueting Wang ◽  
Yuanyuan Zhen ◽  
Ning Li ◽  
Shaohong Jiang ◽  
...  
Keyword(s):  
Delivery System ◽  
Vaccine Adjuvant ◽  
Microneedle Arrays

scholarly journals Multifunctional particle-constituted microneedle arrays as cutaneous or mucosal vaccine adjuvant-delivery systems

2016 ◽  
Vol 12 (8) ◽  
pp. 2075-2089 ◽  
Author(s):  
Xueting Wang ◽  
Ning Wang ◽  
Ning Li ◽  
Yuanyuan Zhen ◽  
Ting Wang
Keyword(s):  
Delivery Systems ◽  
Mucosal Vaccine ◽  
Vaccine Adjuvant ◽  
Microneedle Arrays

scholarly journals The Mucosal Vaccine Adjuvant LT(R192G/L211A) or dmLT

mSphere ◽  
2018 ◽  
Vol 3 (4) ◽  
Author(s):  
John D. Clements ◽  
Elizabeth B. Norton
Keyword(s):  
Cytotoxic T Lymphocytes ◽  
The United States ◽  
Mechanisms Of Action ◽  
Mucosal Vaccine ◽  
Vaccine Adjuvant ◽  
Specific Response ◽  
Preclinical Studies ◽  
Content Type ◽  
Clinical Investigations ◽  
Iga Antibodies

ABSTRACTPerhaps the best-studied mucosal adjuvants are the bacterially derived ADP-ribosylating enterotoxins. This adjuvant family includes heat-labile enterotoxin ofEscherichia coli(LT), cholera toxin (CT), and mutants or subunits of LT and CT. These proteins promote a multifaceted antigen-specific response, including inflammatory Th1, Th2, Th17, cytotoxic T lymphocytes (CTLs), and antibodies. However, more uniquely among adjuvant classes, they induce antigen-specific IgA antibodies and long-lasting memory to coadministered antigens when delivered mucosally or even parenterally. The purpose of this minireview is to describe the general properties, history and creation, preclinical studies, clinical studies, mechanisms of action, and considerations for use of the most promising enterotoxin-based adjuvant to date, LT(R192G/L211A) or dmLT. This review is timely due to completed, ongoing, and planned clinical investigations of dmLT in multiple vaccine formulations by government, nonprofit, and industry groups in the United States and abroad.

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