This paper describes the author's involvement in the early experiences of a start-up biotechnology company created outside the university environment. In this case, two self-employed, entrepreneurial scientists with no university affiliation developed commercializable intellectual property. Falling outside the more common university technology commercialization process, there were a number of issues that were quite different from those a typical university start-up company might face, and these are illustrated. Most importantly, this case is an exemplar of how other non-university entrepreneurs might contemplate utilizing universities to further their technology commercialization objectives.