Relations between fatty acid activation and adenine nucleotide translocase systems in mitochondria

1976 ◽  
Vol 82 (4) ◽  
pp. 1496-1498
Author(s):  
Yu. M. Konstantinov ◽  
V. V. Lyakhovich ◽  
A. V. Panov
Keyword(s):  
Fatty Acid ◽  
Adenine Nucleotide ◽  
Adenine Nucleotide Translocase ◽  
Acid Activation ◽  
Fatty Acid Activation

scholarly journals Mechanistic Studies of Fatty Acid Activation by CYP152 Peroxygenases Reveal Unexpected Desaturase Activity

ACS Catalysis ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 565-577 ◽  
Author(s):  
Mathias Pickl ◽  
Sara Kurakin ◽  
Fabián G. Cantú Reinhard ◽  
Philipp Schmid ◽  
Alexander Pöcheim ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Desaturase Activity ◽  
Acid Activation ◽  
Mechanistic Studies ◽  
Fatty Acid Activation

Yarrowia lipolytica AAL genes are involved in peroxisomal fatty acid activation

2016 ◽  
Vol 1861 (7) ◽  
pp. 555-565 ◽  
Author(s):  
Rémi Dulermo ◽  
Heber Gamboa-Meléndez ◽  
Rodrigo Ledesma‐Amaro ◽  
France Thevenieau ◽  
Jean-Marc Nicaud
Keyword(s):  
Fatty Acid ◽  
Yarrowia Lipolytica ◽  
Acid Activation ◽  
Fatty Acid Activation ◽  
Peroxisomal Fatty Acid

scholarly journals The basal proton conductance of mitochondria depends on adenine nucleotide translocase content

2005 ◽  
Vol 392 (2) ◽  
pp. 353-362 ◽  
Author(s):  
Martin D. Brand ◽  
Julian L. Pakay ◽  
Augustine Ocloo ◽  
Jason Kokoszka ◽  
Douglas C. Wallace ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Metabolic Rate ◽  
Adenine Nucleotide ◽  
Adenine Nucleotide Translocase ◽  
Proton Leak ◽  
Proton Conductance ◽  
Wild Type ◽  
Muscle Mitochondria ◽  
Mild Uncoupling ◽  
Molecular Nature

The basal proton conductance of mitochondria causes mild uncoupling and may be an important contributor to metabolic rate. The molecular nature of the proton-conductance pathway is unknown. We show that the proton conductance of muscle mitochondria from mice in which isoform 1 of the adenine nucleotide translocase has been ablated is half that of wild-type controls. Overexpression of the adenine nucleotide translocase encoded by the stress-sensitive B gene in Drosophila mitochondria increases proton conductance, and underexpression decreases it, even when the carrier is fully inhibited using carboxyatractylate. We conclude that half to two-thirds of the basal proton conductance of mitochondria is catalysed by the adenine nucleotide carrier, independently of its ATP/ADP exchange or fatty-acid-dependent proton-leak functions.

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