Randomized clinical trial of long-term outcome after curative resection of pancreatic head cancer by post-operative intra-arterial infusion chemotherapy

2004 ◽  
Vol 11 (S2) ◽  
pp. S52-S52 ◽  
Author(s):  
S. Nakamori ◽  
A. Miyamoto ◽  
Y. Takahashi ◽  
M. Tsujie ◽  
S. Marubashi ◽  
...  
Keyword(s):  
Curative Resection ◽  
Pancreatic Head ◽  
Arterial Infusion ◽  
Term Outcome ◽  
Head Cancer ◽  
Long Term Outcome ◽  
Arterial Infusion Chemotherapy ◽  
Infusion Chemotherapy ◽  
Pancreatic Head Cancer

Perioperative and Long-Term Outcome after Standard Pancreaticoduodenectomy, Additional Portal Vein and Multivisceral Resection for Pancreatic Head Cancer

2015 ◽  
Vol 19 (3) ◽  
pp. 438-444 ◽  
Author(s):  
Birte Kulemann ◽  
Jens Hoeppner ◽  
Uwe Wittel ◽  
Torben Glatz ◽  
Tobias Keck ◽  
...  
Keyword(s):  
Portal Vein ◽  
Pancreatic Head ◽  
Multivisceral Resection ◽  
Term Outcome ◽  
Head Cancer ◽  
Long Term Outcome ◽  
Pancreatic Head Cancer

Surgery Indeed has an Important Role in Long-Term Outcome in Patients with Pancreatic Head Cancer

2013 ◽  
Vol 38 (6) ◽  
pp. 1558-1559
Author(s):  
Darko Zdravkovic ◽  
Dragoljub Bilanovic ◽  
Tomislav Randjelovic ◽  
Marija Zdravkovic ◽  
Srdjan Dikic
Keyword(s):  
Pancreatic Head ◽  
Term Outcome ◽  
Head Cancer ◽  
Long Term Outcome ◽  
Pancreatic Head Cancer

scholarly journals Surgery Indeed has an Important Role in Long-Term Outcome in Patients with Pancreatic Head Cancer by Zdravkovic et al.

2014 ◽  
Vol 38 (8) ◽  
pp. 2192-2193
Author(s):  
David Petermann ◽  
Nicolas Demartines ◽  
Markus Schafer
Keyword(s):  
Pancreatic Head ◽  
Term Outcome ◽  
Head Cancer ◽  
Long Term Outcome ◽  
Pancreatic Head Cancer

Short- and long-term outcome of pancreaticoduodenectomy with or without portal/superior mesenteric vein resection for pancreatic head cancer: A Japanese single hospital experience

Pancreatology ◽  
2014 ◽  
Vol 14 (3) ◽  
pp. S34
Author(s):  
Meidai Kasai ◽  
Jun-ichiro Yamauchi ◽  
Kousuke Kanazawa ◽  
Ataru Satou ◽  
Yasuyuki Matuda ◽  
...  
Keyword(s):  
Superior Mesenteric Vein ◽  
Pancreatic Head ◽  
Term Outcome ◽  
Head Cancer ◽  
Long Term Outcome ◽  
Pancreatic Head Cancer ◽  
Mesenteric Vein ◽  
Short And Long Term ◽  
Vein Resection

scholarly journals Locally Advanced Pancreatic Head Cancer: Margin-Positive Resection or Bypass?

ISRN Surgery ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ulrich Friedrich Wellner ◽  
Frank Makowiec ◽  
Dirk Bausch ◽  
Jens Höppner ◽  
Olivia Sick ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Locally Advanced ◽  
Pancreatic Head ◽  
Resection Margins ◽  
Term Outcome ◽  
Term Survival ◽  
Long Term Outcome ◽  
Pancreatic Head Cancer ◽  
Margin Positive

Pancreatic cancer is a highly aggressive disease with poor survival. The only effective therapy offering long-term survival is complete surgical resection. In the setting of nonmetastatic disease, locally advanced tumors constitute a technical challenge to the surgeon and may result in margin-positive resection margins. Few studies have evaluated the implications of the latter in depth. The aim of this study was to compare the margin-positive situation to palliative bypass procedures and margin-negative resections in terms of perioperative and long-term outcome. By retrospective analysis of prospectively maintained data from 360 patients operated for pancreatic cancer at our institution, we provide evidence that margin-positive resection still yields a significant survival benefit over palliative bypass procedures. At the same time, perioperative severe morbidity and mortality are not significantly increased. Our observations suggest that pancreatic cancer should be resected whenever technically feasible, including, cases of locally advanced disease.

scholarly journals Impact of Radical Pancreaticoduodenectomy with Portal Vein Resection and Extensive Surrounding Soft Tissues on the Long-term Outcomes for Pancreatic Head Cancer

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S63
Author(s):  
A. Saiura ◽  
H. Ito ◽  
A. Oba ◽  
Y. Inoue ◽  
Y. Mise ◽  
...  
Keyword(s):  
Portal Vein ◽  
Soft Tissues ◽  
Pancreatic Head ◽  
Portal Vein Resection ◽  
Long Term Outcomes ◽  
Head Cancer ◽  
Pancreatic Head Cancer ◽  
Vein Resection

Results of complex treatment of patients with operable pancreatic head cancer using preoperative intra-arterial chemotherapy in combination with radiation therapy in multifractionation mode

2022 ◽  
pp. 32-36
Author(s):  
D. A. Sklyar ◽  
A. V. Pavlovsky ◽  
A. A. Polikarpov ◽  
S. A. Popov ◽  
V. E. Moiseenko ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Pancreatic Head ◽  
Main Group ◽  
Arterial Infusion ◽  
Conformal Radiation Therapy ◽  
Head Cancer ◽  
Pancreatic Head Cancer ◽  
Postoperative Pancreatitis ◽  
Pancreatic Fistulas ◽  
And Control

The aim of this study was to assess the safety and efficacy of treating patients with operable pancreatic cancer after preoperative intra-arterial infusion of chemotherapy combined with conformal radiation therapy in a multi-fractionation mode. Patients (n = 40) were randomized into two groups: the main one – intra-arterial infusion of chemotherapy + radiation therapy + surgery (n = 20), and control – intra-arterial infusion of chemotherapy + surgery (n = 20). Neoadjuvant therapy consisted of intra-arterial infusion of chemotherapy (chemoembolization of a pancreatic head tumor with oxaliplatin 85 mg/m2) followed by intra-arterial chemo infusion with gemcitabine 1000 mg/m2. In the main group, radiation therapy was also carried out in two fractions per day, 2 Gy with an interval of 4–6 hours, 5 days a week, up to a total dose of 50 Gy. In the main group, the lower incidence of postoperative pancreatitis and the pancreatic fistulas were statistically confirmed, the incidence of grade 2 therapeutic pathomorphisis increased, as well as the median life expectancy.

756 LONG-TERM OUTCOME AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR ENTIRE CIRCUMFERENTIAL CT1AN0M0 ESOPHAGEAL SQUAMOUS CELL CARCINOMA

2021 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Atsushi Inaba ◽  
Tomohiro Kadota ◽  
Keiichiro Nishihara ◽  
Daiki Sato ◽  
Keiichiro Nakajo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Curative Resection ◽  
Response Rate ◽  
Complete Response Rate ◽  
Complete Response ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Stricture Rate

Abstract   Endoscopic submucosal dissection (ESD) is the standard treatment for cT1a esophageal squamous cell carcinoma (ESCC), however its indication for the entire circumferential lesions is still controversial because of the risk of severe stricture after ESD. Therefore, several treatment options are performed based on physicians’ choice, however, each clinical course is unclear. This study aimed to clarify the long-term outcome after ESD for patients with entire circumferential cT1aN0M0 ESCC, comparing with esophagectomy or chemoradiotherapy. Methods Patients with entire circumferential cT1aN0M0 SESCC treated with ESD, chemoradiotherapy, or esophagectomy as the initial treatment between January 2010 and December 2016 in our institution were included. Patients who had a history of any malignancy at cStage II-IV within 5 years were excluded. The 5-year overall survival (OS), 5-year disease-free survival (DFS), stricture rate, refractory stricture rate (defined as requiring >6 dilations), curative resection (defined as pT1a without lymphovascular invasion and negative for vertical margin in the pathological evaluation) rate of ESD, and complete response rate of chemoradiotherapy were evaluated for each treatment. Results Of the 48 eligible patients, 25/13/10 patients were performed ESD/chemoradiotherapy/esophagectomy as an initial treatment. Curative resections rate of ESD was 72%, and additional esophagectomy and chemoradiotherapy were performed in three and one patients with non-curative resection. Complete response rate of chemoradiotherapy was 100%, however, 4 patients had recurrence thereafter. No recurrences occurred after esophagectomy in all patients treated with esophagectomy. During median follow-up of 83 months, stricture and refractory stricture rate was 80/44% after ESD, 0/0% after chemoradiotherapy, and 20/10% after esophagectomy. The 5-year OS/DFS was 91/87% after ESD, 92/59% after chemoradiotherapy, and 90/90% after esophagectomy. Conclusion While some patients required additional treatments due to non-curative resection, the long-term survival after ESD for circumferential cT1aN0M0 ESCC was similar as those after chemoradiotherapy or esophagectomy. In contrast, the stricture and refractory stricture rate after ESD was higher than others. Further investigation in a large cohort is necessary to clarify the indication criteria of ESD for patients with the lesion.

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