Stimulatory effect of nobiletin, a citrus polymethoxy flavone, on catecholamine synthesis through Ser19 and Ser40 phosphorylation of tyrosine hydroxylase in cultured bovine adrenal medullary cells

2013 ◽  
Vol 387 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Han Zhang ◽  
Nobuyuki Yanagihara ◽  
Yumiko Toyohira ◽  
Keita Takahashi ◽  
Hirohide Inagaki ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Catecholamine Synthesis ◽  
Adrenal Medullary Cells ◽  
Medullary Cells

scholarly journals Stimulation of Catecholamine Synthesis by Environmental Estrogenic Pollutants

Endocrinology ◽  
2005 ◽  
Vol 146 (1) ◽  
pp. 265-272 ◽  
Author(s):  
Nobuyuki Yanagihara ◽  
Yumiko Toyohira ◽  
Susumu Ueno ◽  
Masato Tsutsui ◽  
Kensuke Utsunomiya ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
The United States ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Catecholamine Synthesis ◽  
Adrenal Medullary Cells ◽  
Regulatory Standard ◽  
Long Term Treatment ◽  
Medullary Cells

Environmental estrogenic pollutants are compounds that have been shown to have estrogenic effects on fetal development and reproductive systems. Less attention, however, has been paid to their influence on neuronal functions. We report here the effects of estrogenic pollutants on catecholamine synthesis in bovine adrenal medullary cells used as a model system of noradrenergic neurons. Treatment of cultured bovine adrenal medullary cells with p-nonylphenol and bisphenol A at 10 nm for 3 d stimulated [14C]catecholamine synthesis from [14C]tyrosine and tyrosine hydroxylase activity, an effect that was not inhibited by ICI 182,780, an antagonist of estrogen receptors. Significant effects of p-nonylphenol on [14C]catecholamine synthesis were observed at 0.1 nm, which is 45 times lower than that of the international regulatory standard (4.5 nm), and the maximum effects were around 10–100 nm. The concentrations (0.1–10 nm) used in the present study are similar to the range observed in rivers in the United States or Europe. On the other hand, short-term treatment of cells with 10 nmp-nonylphenol for 10 min also activated tyrosine hydroxylase, which was suppressed by U0126, an inhibitor of MAPK kinase. Furthermore, treatment of cells with p-nonylphenol for 5 min increased the phospho-p44/42MAPK in a concentration-dependent (1–1000 nm) manner, whereas p-nonylphenol (100 nm, 2 d) enhanced both levels of non-phospho- and phospho-p44/42MAPK. These findings suggest that short-term and long-term treatment of cells with estrogenic pollutants at environmental concentrations stimulates catecholamine synthesis and MAPK through an estrogen receptor-independent pathway.

scholarly journals Stimulatory effects of low density lipoprotein on catecholamine synthesis in cultured bovine adrenal medullary cells

1999 ◽  
Vol 79 ◽  
pp. 196
Author(s):  
Koji Kajiwara ◽  
Nobuyuki Yanagihara ◽  
Masato Tsutsui ◽  
Yumiko Toyohira ◽  
Yasuhito Uezono ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Catecholamine Synthesis ◽  
Adrenal Medullary Cells ◽  
Medullary Cells

Lithium chloride stimulates catecholamine synthesis and secretion in cultured bovine adrenal medullary cells

1992 ◽  
Vol 31 (10) ◽  
pp. 1038-1049 ◽  
Author(s):  
Takeshi Terao ◽  
Nobuyuki Yanagihara ◽  
Kazuhiko Abe ◽  
Futoshi Izumi
Keyword(s):  
Lithium Chloride ◽  
Catecholamine Synthesis ◽  
Adrenal Medullary Cells ◽  
Medullary Cells

scholarly journals Activation of tyrosine hydroxylase by micromolar concentrations of Ca in leaky adrenal medullary cells and PC12 cells

1986 ◽  
Vol 40 ◽  
pp. 212
Author(s):  
Nobuyuki Yanagihara ◽  
Yasuhito Uezono ◽  
Yoshiro Koda ◽  
Akihiko Wada ◽  
Futoshi Izumi
Keyword(s):  
Tyrosine Hydroxylase ◽  
Pc12 Cells ◽  
Adrenal Medullary Cells ◽  
Medullary Cells

scholarly journals Dual Effects of Daidzein, a Soy Isoflavone, on Catecholamine Synthesis and Secretion in Cultured Bovine Adrenal Medullary Cells

Endocrinology ◽  
2007 ◽  
Vol 148 (11) ◽  
pp. 5348-5354 ◽  
Author(s):  
Minhui Liu ◽  
Nobuyuki Yanagihara ◽  
Yumiko Toyohira ◽  
Masato Tsutsui ◽  
Susume Ueno ◽  
...  
Keyword(s):  
Soy Isoflavone ◽  
Catecholamine Synthesis ◽  
Adrenal Medullary Cells ◽  
Medullary Cells

Vitamin D increases expression of the tyrosine hydroxylase gene in adrenal medullary cells

1996 ◽  
Vol 36 (1) ◽  
pp. 193-196 ◽  
Author(s):  
Elzbieta Puchacz ◽  
Walter E. Stumpf ◽  
Ewa K. Stachowiak ◽  
Michal K. Stachowiak
Keyword(s):  
Vitamin D ◽  
Tyrosine Hydroxylase ◽  
Tyrosine Hydroxylase Gene ◽  
Hydroxylase Gene ◽  
Adrenal Medullary Cells ◽  
Medullary Cells
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