Silver nanoparticles effect on drug release of metronidazole in natural rubber latex dressing

The mucous liquid of Hevea brasiliensis or Para rubber tree, called natural rubber latex (NRL), composes of cis-1,4-polyisoprene which can form a patch under suitable formulation. In this study, blank and 5% lidocaine-loaded NRL patches were formulated and then characterized for physicochemical properties as well as evaluated in vitro drug release and stability. The patches were observed for their appearances. Surface morphology of the patches was investigated using a SEM. XRD was employed to study the crystallinity of the drug, the patch, and the drug-loaded patch. The extractions of lidocaine-loaded patches were analyzed for drug contents by HPLC. In vitro drug release study was performed using modified Franz diffusion cells. The patches at initial preparation and after kept at 4, 25, and 45 °C for 3 months were investigated for the stability determination. The results suggested that NRL could be used as a main component in pharmaceutical transdermal patches with acceptable physicochemical properties. Lidocaine-loaded NRL patches provided desirable drug release but high storage temperatures could age the patches resulting in darken color and lower release amount.

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PMMA particles coated with chitosan-silver nanoparticles as a dual antibacterial modifier for natural rubber latex films

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2018.11.037 ◽

2019 ◽

Vol 174 ◽

pp. 544-552 ◽

Cited By ~ 7

Author(s):

Teeraporn Suteewong ◽

Jitrada Wongpreecha ◽

Duangporn Polpanich ◽

Kulachart Jangpatarapongsa ◽

Chariya Kaewsaneha ◽

...

Keyword(s):

Silver Nanoparticles ◽

Natural Rubber ◽

Natural Rubber Latex ◽

Latex Films ◽

Rubber Latex ◽

Pmma Particles

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Propranolol Hydrochloride Extended-Release Matrix Tablets Using Natural Rubber Latex as Binder

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.747.91 ◽

2013 ◽

Vol 747 ◽

pp. 91-94 ◽

Cited By ~ 1

Author(s):

Kamon Panrat ◽

Prapaporn Boonme ◽

Wirach Taweepreda ◽

Wiwat Pichayakorn

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Natural Rubber ◽

Release Rate ◽

Drug Delivery Systems ◽

Natural Rubber Latex ◽

Delivery Systems ◽

Matrix Tablets ◽

Propranolol Hydrochloride ◽

Rubber Latex

Matrix is one of the most interesting drug delivery systems to control drug release in pharmaceutical dosage forms. Natural rubber latex (NRL) from Hevea brasiliensis consists of cis-1,4-polyisoprene as the major polymer. It presents interesting physical properties such as easy to manipulate, low cost, high mechanical resistance, and insoluble in water. The aim of this study was to use the NRL as binder in matrix tablets for controlling the release rate of drug. NRL, sodium carboxymethylcellulose, olive oil, Tween 80, and lactose were used as polymer, adsorbent, plasticizer, surfactant, and diluent, respectively. Propranolol hydrochloride was used as a model drug. Propranolol hydrochloride matrix tablets were prepared by conventional heat-melting method. The in vitro release of drug from matrix tablets was determined by UV-Vis method according to dissolution test under Propranolol Hydrochloride Tablets USP30-NF25 monograph. Morphology of propranolol hydrochloride matrix tablet before and after released study was observed by scanning electron microscopy (SEM). It was found that NRL matrix tablets could control the drug release up to 12 hours. The release profiles were best fitted with Higuchi model. NRL amounts affected the properties of the propranolol hydrochloride matrix tablets. Increasing the NRL quantity in the matrices provided the decrease of release rate of drug. SEM photographs showed the number, size, and distribution of pore in propranolol hydrochloride matrix tablets that depended on amount of NRL addition. These results confirmed that NRL was possible to use as binder for matrix tablets in oral drug delivery systems.

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Effects of silver nanoparticles on physical and antibacterial properties of natural rubber latex foam

Materials Today Proceedings ◽

10.1016/j.matpr.2019.06.230 ◽

2019 ◽

Vol 17 ◽

pp. 1914-1920 ◽

Cited By ~ 1

Author(s):

Khemara Mam ◽

Rapeephun Dangtungee

Keyword(s):

Silver Nanoparticles ◽

Natural Rubber ◽

Natural Rubber Latex ◽

Antibacterial Properties ◽

Rubber Latex

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The Role of Ammonia in Synthesis of Silver Nanoparticles in Skim Natural Rubber Latex

Journal of Nanoscience ◽

10.1155/2016/7258313 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Panu Danwanichakul ◽

Thanawat Suwatthanarak ◽

Chidchanok Suwanvisith ◽

Duangkamol Danwanichakul

Keyword(s):

Silver Nanoparticles ◽

Natural Rubber ◽

Natural Rubber Latex ◽

Ammonia Concentration ◽

Rubber Latex ◽

Controlling Effect ◽

Uv Visible ◽

Size Controlling ◽

Latex Production

Silver nanoparticles (AgNPs) were synthesized in skim natural rubber latex, the by-product from concentrated latex production. The role of ammonia was investigated by varying the concentration to be 0.217, 0.362, 0.377, 0.392, and 0.406 wt%. The emergence of AgNPs was detected by UV-visible spectrophotometer and electrical conductivity meter. Upon increasing ammonia concentration, the ABS peak increased to a maximum and slightly shifted to a higher wavelength and then it decreased afterward and slightly shifted to a lower wavelength. The shift of the ABS peak was consistent with the conductivity result. The kinetic model was proposed to explain the competition between the reducing effect and size-controlling effect of ammonia. The reducing effect seemed to dominate in the low range of concentration while the size-controlling effect via the formation of AgNH32+ complex ion was important in the higher range. The TEM figures evidently confirmed the effects.

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