scholarly journals Self-limiting COVID‐19-associated Kikuchi‐Fujimoto disease with heart involvement: case-based review

2022 ◽  
Author(s):  
Anna Masiak ◽  
Amanda Lass ◽  
Jacek Kowalski ◽  
Adam Hajduk ◽  
Zbigniew Zdrojewski
Keyword(s):  
Medical Journal ◽  
Autoimmune Diseases ◽  
Causative Agent ◽  
Rare Case ◽  
Clinical Course ◽  
Unknown Origin ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Heart Involvement ◽  
Necrotizing Lymphadenitis ◽  
Case Based

Abstract Background The association between COVID-19 infection and the development of autoimmune diseases is currently unknown, but there are already reports presenting induction of different autoantibodies by SARS-CoV-2 infection. Kikuchi-Fuimoto disease (KFD) as a form of histiocytic necrotizing lymphadenitis of unknown origin. Objective Here we present a rare case of KFD with heart involvement after COVID-19 infection. To our best knowledge only a few cases of COVID-19-associated KFD were published so far. Based on presented case, we summarize the clinical course of KFD and its association with autoimmune diseases, as well we discuss the potential causes of perimyocarditis in this case. Methods We reviewed the literature regarding cases of “Kikuchi-Fujimoto disease (KFD)” and “COVID-19” and then “KFD” and “heart” or “myocarditis” by searching medical journal databases written in English in PubMed and Google Scholar. Results Only two cases of KFD after COVID infection have been described so far. Conclusion SARS-CoV-2 infection can also be a new, potential causative agent of developing KFD.

scholarly journals Leptospirosis presenting as severe cardiogenic shock: A case report

2018 ◽  
Vol 19 (4) ◽  
pp. 351-353
Author(s):  
E Forbat ◽  
MJ Rouhani ◽  
C Pavitt ◽  
S Patel ◽  
R Handslip ◽  
...  
Keyword(s):  
Case Report ◽  
Cardiogenic Shock ◽  
Social History ◽  
Rare Case ◽  
Clinical Course ◽  
Unknown Origin ◽  
Case Presentation ◽  
Pyrexia Of Unknown Origin ◽  
Severe Cardiogenic Shock ◽  
Infectious Illness

Background Leptospirosis is a rare infectious illness caused by the Spirochaete Leptospira. It has a wide-varying spectrum of presentation. We present a rare case of severe cardiogenic shock secondary to leptospirosis, in the absence of its common clinical features. Case presentation A 36-year-old woman presented to our unit with severe cardiogenic shock and subsequent multi-organ failure. Her clinical course was characterised by ongoing pyrexia of unknown origin with concurrent cardiac failure. She was initially managed with broad-spectrum antibiotics and inotropes. Percutaneous cardiac biopsy excluded major causes of myocarditis. On day 21 after presentation, she was found to be IgM-positive for leptospirosis. Conclusions This is a rare case of severe cardiogenic shock secondary to leptospirosis infection. The case also highlights the importance of obtaining a thorough social history when assessing a patient with an unusual presentation, as clues can often be missed.

scholarly journals AB1051 KIKUCHI FUJIMOTO DISEASE, IS IT SLE?

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1815.3-1816
Author(s):  
J. Camins-Fàbregas ◽  
V. Ortiz-Santamaria ◽  
N. Busquets-Pérez ◽  
A. Cuervo ◽  
I. Cañas Alcántara ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Autoimmune Diseases ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Response To Treatment ◽  
Systemic Autoimmune Disease ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Systemic Autoimmune Diseases ◽  
Necrotizing Lymphadenitis

Background:Kikuchi-Fujimoto disease (KFD) is a rare entity characterized by adenopathies and fever. It raises a broad differential diagnosis that includes lymphoproliferative disorders, infections and systemic autoimmune diseases, and diagnostic confirmation is always by histology, which shows histiocytic necrotizing lymphadenitis. Although its course is generally benign and self-limited, it can be associated both at the time of diagnosis and during follow-up with systemic autoimmune diseases, the most frequent of which is systemic lupus erythematosus (SLE).Objectives:To describre the clinical and analytical characteristics of patients diagnosed with KFD and the development of systemic autoimmune disease.Methods:Patients diagnosed with KFD during the 1990s and 2020s are collected in a regional hospital (Granollers General Hospital). The clinic is documented at the diagnosis of EKF, the appearance of systemic autoimmune disease during follow-up and its clinical and analytical characteristics.Results:A total of 7 patients with EKF were diagnosed. All of them women with a mean age at diagnosis of 30 years. Diagnosis was made in all cases with compatible clinical symptoms, fever and lymphadenopathy, and lymph node biopsy confirming histiocytic necrotizing lymphadenitis. At the time of diagnosis, a patient was also diagnosed with SLE. During the follow-up, 4 of the 6 remaining patients developed clinical manifestations compatible with SLE (3 of them with systemic manifestations and a case of subacute cutaneous lupus. The mean time of onset of SLE was 34 months (between 6 months and 5 years). All of them received treatment with hydroxychloroquine, with good response to treatment.The clinical and analytical characteristics are presented in Table 1 below.Conclusion:In our center, 5 of the 7 patients (71%) diagnosed with EKF developed manifestations compatible with SLE. The importance of the diagnosis of EKF lies precisely in the possible association with systemic autoimmune disease, the most common being SLE, so it is recommended that patients be monitored to identify those who develop associated autoimmune disease.Disclosure of Interests:None declared

Kikuchi's disease of the neck (histiocytic necrotizing lymphadenitis)

1998 ◽  
Vol 112 (9) ◽  
pp. 898-900 ◽  
Author(s):  
N. A. Bhat ◽  
Ye Lim Hock ◽  
N. O. Turner ◽  
A. R. Das Gupta
Keyword(s):  
Lymph Nodes ◽  
Unknown Origin ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Review Of The Literature ◽  
Cervical Lymph Nodes ◽  
Young Females ◽  
Kikuchi’S Disease ◽  
Necrotizing Lymphadenitis ◽  
Kikuchi's Disease

AbstractHistocytic necrotizing lymphadenitis (HNL), also known as Kikuchi's disease is a benign self limiting disease of unknown origin. It effects cervical lymph nodes, predominantly in young females. It is well described in the pathology literature, but little is written about this in the ENT literature, as few clinicians are probably aware of this condition. Five cases of cervical Kikuchi's disease are presented with a brief review of the literature.

scholarly journals Kikuchi-Fujimoto Disease: A Rare Case Report from Nepal

2021 ◽  
Author(s):  
Rahul Rauniyar ◽  
Kshitiz Acharya ◽  
Aman Mishra ◽  
Nibesh Pathak ◽  
Gajendra Chaudhary ◽  
...  
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Rare Case ◽  
Cervical Lymphadenopathy ◽  
Differential Diagnoses ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Rare Case Report ◽  
Necrotizing Lymphadenitis ◽  
Limiting Condition

Kikuchi-Fujimoto Disease (KFD), also called histiocytic necrotizing lymphadenitis, is a rare benign self-limiting condition, commonly characterized by cervical lymphadenopathy and fever. KFD must be included in the differential diagnoses of lymphadenopathy. Clinicians and pathologists should be aware of the occurrence of this entity, for early diagnosis.

scholarly journals Histiocytic necrotizing lymphadenitis (Kikuchi lymphadenitis) in an HIV-positive patient

2002 ◽  
Vol 44 (5) ◽  
pp. 256-268 ◽  
Author(s):  
José VASSALLO ◽  
João Carlos COELHO FILHO ◽  
Vânia Gondin Pires do AMARAL
Keyword(s):  
Human Immunodeficiency Virus ◽  
Infected Patient ◽  
Clinical Course ◽  
Hiv Positive ◽  
Hybridization Technique ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Immunological Status ◽  
Immunodeficiency Virus ◽  
Necrotizing Lymphadenitis

Histiocytic necrotizing lymphadenitis, or Kikuchi's lymphadenitis (KL), is an unusual form of lymphadenitis, generally with self-limited clinical course. KL has been reported in rare patients infected with the human immunodeficiency virus (HIV). Pathogenesis of the lesion is probably related to an impaired immune function. The purpose of the present article is to report on one case in which KL was diagnosed in an HIV-infected patient. Histomorphology and immunophenotype were similar to previous reports, but a focus of activated CD30+ macrophages was seen, what might be due to the immunological status of the patient. EBV was not detected on the sections using the in situ hybridization technique. Although rare, the occurrence of KL in HIV-infected subjects must be emphasized, because of the potential misdiagnosis of malignancy, especially in the presence of CD30+ cells.

Histiocytic necrotizing lymphadenitis: Report of a case.

1989 ◽  
Vol 51 (2) ◽  
pp. 227-231
Author(s):  
Norio TAKAHASHI ◽  
Minoru HOSHINO ◽  
Toru BABA ◽  
Kenichi UYENO
Keyword(s):  
Histiocytic Necrotizing Lymphadenitis ◽  
Necrotizing Lymphadenitis

Screening for celiac disease among children with overweight and obesity: toward exploring celiac iceberg

2020 ◽  
Vol 33 (8) ◽  
pp. 995-1002
Author(s):  
Valeria Calcaterra ◽  
Corrado Regalbuto ◽  
Matteo Manuelli ◽  
Catherine Klersy ◽  
Gloria Pelizzo ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Weight Gain ◽  
Autoimmune Diseases ◽  
Medical History ◽  
Unknown Origin ◽  
Overweight And Obesity ◽  
Excessive Weight Gain ◽  
Familial Predisposition ◽  
Excessive Weight ◽  
Hla Dq2

AbstractObjectivesThe coexistence of celiac disease (CD) and obesity/overweight is not unusual. We investigate the prevalence and clinical presentation of CD, detected by screening, among children with excessive weight gain.MethodsWe enrolled 200 children referred for overweight/obesity to our outpatient clinic. Medical history during pregnancy and childhood and lifestyle variables were recorded. Patients were screened for CD with total immunoglobulin A (IgA), IgA anti-transglutaminase (tTG-IgA) and IgA anti-endomysial antibodies (EMA-IgA). In subjects with positive autoantibodies, esophagogastroduodenoscopy (EGDS) was performed and genetic testing for HLA DQ2 and/or DQ8 haplotypes was tested.ResultsCD positive antibodies (tTg-IgA and EMA-IgA) were detected in eight patients (4%); in all subjects CD diagnosis was confirmed by HLA-DQ2 and/or DQ8 compatibility and EGDS. No association between CD and medical history during pregnancy and childhood or lifestyle variables was noted; however, a dietary difference was identified with those testing positive for CD also reporting a lower weekly consumption of fruits and vegetables (p=0.04). Headache was reported more frequently in patients with than without CD (p=0.04). Familiar positivity for autoimmune diseases was revealed in CD patients (p=0.01).ConclusionCD should be considered in children with excessive weight gain. Familial predisposition to other autoimmune diseases may represent a risk factor for development of CD. Even though the relationship between headache and CD is not well defined, the patients with headache of unknown origin should be screened for CD.

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