scholarly journals Boron Intake and decreased risk of mortality in kidney transplant recipients

Author(s):  
Daan Kremer ◽  
Adrian Post ◽  
Ulrike Seidel ◽  
Patricia Huebbe ◽  
Yvonne van der Veen ◽  
...  

Abstract Purpose In a search for potentially modifiable factors to improve long-term outcome among kidney transplant recipients (KTR), we hypothesized that boron exposure is associated with improved long-term outcome in KTR. Methods We determined 24 h urinary boron excretion using inductively coupled plasma mass spectrometry as a measure of boron exposure in 693 stable KTR (57% male, mean age 53y), enrolled in the TransplantLines Food and Nutrition Biobank and Cohort Study. Dietary intake was assessed using validated food-frequency questionnaires. Results Linear regression analyses showed that dietary intake of fruit, wine and nuts were key determinants of boron excretion. In addition, boron excretion was negatively correlated with homocysteine and inflammatory parameters. In total, 73 (32%), 47 (20%) and 30 (13%) KTR died among the lowest, middle and highest tertiles of 24 h urinary boron excretion, respectively (Plog-rank < 0.001). Cox regression analyses showed that high boron excretion was strongly associated with lower risk of mortality, independent of age, sex, estimated glomerular filtration rate and history of cardiovascular disease (HR per doubling: 0.51, 95% CI: 0.40 to 0.66, P < 0.001). Conclusion Boron may be an overlooked target to improve long-term survival among KTR and potentially other patients, likely through pathways other than inflammation or the methionine-homocysteine cycle that were previously suggested. Interventional trials are warranted to confirm the potential of dietary boron supplementation in KTR and other patient populations.

2012 ◽  
Vol 94 (10S) ◽  
pp. 362
Author(s):  
N. Goto ◽  
Y. Matsuda ◽  
M. Takada ◽  
T. Yamamoto ◽  
M. Tsujita ◽  
...  

2015 ◽  
Vol 28 (7) ◽  
pp. 820-827 ◽  
Author(s):  
Christoph Schwarz ◽  
Sophie Mayerhoffer ◽  
Gabriela A. Berlakovich ◽  
Rudolf Steininger ◽  
Thomas Soliman ◽  
...  

2014 ◽  
Vol 98 ◽  
pp. 465 ◽  
Author(s):  
M. Killackey ◽  
E. Khan ◽  
Y. Liu ◽  
D. Kumbala ◽  
H. LaGuardia ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document