Differential expression of programmed cell death ligand 1 (PD-L1) and inflammatory cells in basal cell carcinoma subtypes

2021 ◽  
Author(s):  
Matias Gompertz-Mattar ◽  
Juan Perales ◽  
Aditi Sahu ◽  
Sebastián Mondaca ◽  
Sergio Gonzalez ◽  
...  
Keyword(s):  
Cell Death ◽  
Basal Cell Carcinoma ◽  
Programmed Cell Death ◽  
Cell Carcinoma ◽  
Differential Expression ◽  
Basal Cell ◽  
Inflammatory Cells

Programmed cell death 1 (PDCD1) gene haplotypes and susceptibility of patients to basal cell carcinoma

2021 ◽  
Author(s):  
Farshid Fathi ◽  
Batool Zamani ◽  
Ahmad Piroozmand ◽  
Samaneh Mozafarpoor ◽  
Effat Seyedhashemi ◽  
...  
Keyword(s):  
Cell Death ◽  
Basal Cell Carcinoma ◽  
Programmed Cell Death ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Iranian Population ◽  
Protective Effects ◽  
Healthy Individuals ◽  
Multicenter Studies ◽  
Programmed Cell Death 1

AbstractProgrammed death-1 (PD-1), as an immunoinhibitory receptor encoded by programmed cell death-1 (PDCD1) gene, has a pivotal role in tolerance to self-antigens. Mutations of PDCD1 may participate in susceptibility to basal cell carcinoma (BCC) as the most common of skin cancer. We studied the impacts of two single nucleotide polymorphisms (SNPs) within PDCD1 and their haplotypes in BCC susceptibility in an Iranian population. The blood samples were collected from 210 BCC and 220 healthy individuals. After the extraction of genomic DNA, the genotypes and alleles of PD1.1 G/A (rs36084323) and PD1.6 G/A (rs10204525) SNPs were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Four haplotypes were estimated by these SNPs. Our data revealed that genotype and allele frequencies of PD1.1 and PD1.6 polymorphisms in BCC patients were similar to those in healthy individuals. The results of estimated haplotypes for PDCD1 indicated that GG and AA haplotypes of PDCD1 had protective effects on BCC susceptibility (OR = 0.7, 95% CI = 0.51–0.96, p = 0.03 and OR = 0.57, 95% CI = 0.35–0.91, p = 0.02, respectively), while GA and AG haplotypes served as the risk factors for developing BCC (OR = 1.76, 95% CI = 1.09–2.84, p = 0.02 and OR = 3.87, 95% CI = 1.95–7.69, p = <0.001, respectively). Based on these findings, frequency distributions of PDCD1 haplotypes have important roles in the determination of BCC development in the Iranian population. However, larger multicenter studies are required to confirm this conclusion.

scholarly journals Correction to: Programmed cell death 1 (PDCD1) gene haplotypes and susceptibility of patients to basal cell carcinoma

2021 ◽  
Vol 48 (3) ◽  
pp. 3055-3055
Author(s):  
Farshid Fathi ◽  
Batool Zamani ◽  
Ahmad Piroozmand ◽  
Samaneh Mozafarpoor ◽  
Effat Seyedhashemi ◽  
...  
Keyword(s):  
Cell Death ◽  
Basal Cell Carcinoma ◽  
Programmed Cell Death ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Programmed Cell Death 1

scholarly journals Differential expression patterns of metastasis suppressor proteins in basal cell carcinoma

2014 ◽  
Vol 54 (8) ◽  
pp. 905-915 ◽  
Author(s):  
Onder Bozdogan ◽  
Isik G. Yulug ◽  
Ibrahim Vargel ◽  
Tarik Cavusoglu ◽  
Ayse A. Karabulut ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Differential Expression ◽  
Basal Cell ◽  
Expression Patterns ◽  
Metastasis Suppressor

Differential expression of Bcl-2, Bax, and CD95 in DNA repair-proficient and DNA repair-deficient basal cell carcinoma patients

2006 ◽  
Vol 45 (12) ◽  
pp. 1482-1485 ◽  
Author(s):  
K. Abid ◽  
B. Fazaa ◽  
Ch. Hadouchi ◽  
F. El Mezni ◽  
M. R. Kamoun ◽  
...  
Keyword(s):  
Dna Repair ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Differential Expression ◽  
Basal Cell

Differential expression of α1 (IV) and α5 (IV) collagen chains in basal-cell carcinoma

2003 ◽  
Vol 30 (9) ◽  
pp. 548-552 ◽  
Author(s):  
Pascale Quatresooz ◽  
Oriane Martalo ◽  
Gérald E. Piérard
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Differential Expression ◽  
Basal Cell
Sign in / Sign up

Export Citation Format

Share Document