Exercise improves health-related quality of life sleep and fatigue domains in adult high- and low-grade glioma patients

Abstract Background Glioma patients are not only confronted with the diagnosis and treatment of a brain tumor, but also with changes in cognitive and neurological functioning that can profoundly affect their daily lives. At present, little is known about the relationship between cognitive functioning and health-related quality of life (HRQOL) during the disease trajectory. We studied this association in low-grade glioma (LGG) patients with stable disease at an average of 6 years after diagnosis. Methods Patients and healthy controls underwent neuropsychological testing and completed self-report measures of generic (MOS SF36) and disease-specific (EORTC BN20) HRQOL. Associations were determined with Pearson correlations, and corrections for multiple testing were made. Results We analyzed data gathered from 190 LGG patients. Performance in all cognitive domains was positively associated with physical health (SF36 Physical Component Summary). Executive functioning, processing speed, working memory, and information processing were positively associated with mental health (SF36 Mental Component Summary). We found negative associations between a wide range of cognitive domains and disease-specific HRQOL scales. Conclusions In stable LGG patients, poorer cognitive functioning is related to lower generic and disease-specific HRQOL. This confirms that cognitive assessment of LGG patients should not be done in isolation from assessment of its impact on HRQOL, both in clinical and in research settings.

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OS4.6 Does radiation target volume affect health-related quality of life in patients with low grade glioma on the short-term? - a secondary analysis of the EORTC 22033–26033 trial

Neuro-Oncology ◽

10.1093/neuonc/noy139.031 ◽

2018 ◽

Vol 20 (suppl_3) ◽

pp. iii223-iii224

Author(s):

C Seidel ◽

L Dirven ◽

J C Rejneveld ◽

C Coens ◽

M J B Taphoorn ◽

...

Keyword(s):

Quality Of Life ◽

Secondary Analysis ◽

Target Volume ◽

Low Grade Glioma ◽

Low Grade ◽

Health Related Quality ◽

Short Term ◽

Related Quality ◽

Health Related

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Compromised Health-Related Quality of Life in Patients With Low-Grade Glioma

Journal of Clinical Oncology ◽

10.1200/jco.2011.35.5750 ◽

2011 ◽

Vol 29 (33) ◽

pp. 4430-4435 ◽

Cited By ~ 102

Author(s):

Neil K. Aaronson ◽

Martin J.B. Taphoorn ◽

Jan J. Heimans ◽

Tjeerd J. Postma ◽

Chad M. Gundy ◽

...

Keyword(s):

Quality Of Life ◽

Low Grade Glioma ◽

Low Grade ◽

Healthy Controls ◽

Health Related Quality ◽

Neurocognitive Deficits ◽

Sf 36 ◽

Related Quality ◽

Health Related

Purpose To investigate the generic and condition-specific health-related quality of life (HRQL) of patients with low-grade glioma (LGG). Patients and Methods A total of 195 patients with LGG, which was diagnosed, on average, 5.6 years before the study, were compared with 100 patients with hematologic (non-Hodgkin's) lymphoma and chronic lymphatic leukemia cancer (NHL/CLL) and 205 general population controls who were comparable with patients with LGG at the group level for age, sex, and education (healthy controls). Generic HRQL was assessed with the Short Form-36 (SF-36) Health Survey, and condition-specific HRQL was assessed with the Medical Outcomes Study cognitive function questionnaire and the European Organisation for Research and Treatment of Cancer brain cancer module. Objective neurocognitive functioning was assessed with a standardized battery of neuropsychological tests. Results No statistically significant differences were observed between patients with LGG and patients with NHL/CLL in SF-36 scores. Patients with LGG scored significantly lower than healthy controls on six of eight scales and on the mental health component score of the SF-36. Approximately one quarter of patients with LGG reported serious neurocognitive symptoms. Female sex, epilepsy burden, and number of objectively assessed neurocognitive deficits were associated significantly with both generic and condition-specific HRQL. Clinical variables, including the time since diagnosis, tumor lateralization, extent of surgery, and radiotherapy, did not show a consistent relationship with HRQL. Conclusion Patients with LGG experienced significant problems across a broad range of HRQL domains, many of which were not condition-specific. However, the neurocognitive deficits and epilepsy that were relatively prevalent among patients with LGG were associated with negative HRQL outcomes and, thus, contributed additionally to the vulnerability of this population of patients with cancer.

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