Distress and quality of life do not change over time in patients with operated and conservatively managed intracranial meningioma

Abstract Purpose The patients’ burden with asymptomatic meningiomas and patients with good clinical outcome after meningioma resection often remains neglected. In this study, we aimed to investigate the longitudinal changes of psychological distress and quality of life in these patient groups. Methods Patients with conservatively managed (CM) or operated (OM) meningiomas and excellent neurological status, who were screened for psychological distress during the follow-up visit (t1), were included. We performed a follow-up mail/telephone-based survey 3–6 months (t2) after t1. Distress was measured using Hospital Anxiety and Depression Scale (HADS), Distress Thermometer (DT), 36-item Short Form (SF-36), and Brief Fatigue Inventory (BFI). Results Sixty-two patients participated in t1 and 47 in t2. The number of patients reporting increased or borderline values remained high 3 months after initial presentation, with n = 25 (53%) of patients reporting increased anxiety symptom severity and n = 29 (62%) reporting increased depressive symptom severity values. The proportion of distressed patients according to a DT score remained similar after 3 months. Forty-four percent of patients reported significant distress in OM and 33% in CM group. The most common problems among distressed patients were fatigue (t2 75%) and worries (t2 50%), followed by pain, sleep disturbances, sadness, and nervousness. Tumor progress was associated with increased depression scores (OR 6.3 (1.1–36.7)). Conclusion The level of psychological distress in asymptomatic meningiomas and postoperative meningiomas with excellent outcome is high. Further investigations are needed to identify and counsel the patients at risk.

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Association of fatigue and psychological distress with quality of life in patients with a previous venous thromboembolic event

Thrombosis and Haemostasis ◽

10.1160/th09-05-0316 ◽

2009 ◽

Vol 102 (12) ◽

pp. 1219-1226 ◽

Cited By ~ 18

Author(s):

Paul Lukas ◽

René Krummenacher ◽

Franziska Biasiutti ◽

Stefan Begré ◽

Hansjörg Znoj ◽

...

Keyword(s):

Quality Of Life ◽

Psychological Distress ◽

Thromboembolic Event ◽

Short Form ◽

Depression Scale ◽

Venous Thromboembolic Event ◽

Anxiety And Depression ◽

Blood Collection ◽

Venous Thromboembolic

SummaryHealth-related quality of life (QoL) has been associated with several social and medical conditions in patients with deep vein thrombosis (DVT) and pulmonary embolism (PE).To the best of our knowledge,there is no study investigating the relationship of QoL with psychological variables in this patient population.We assumed as a hypothesis an association between heightened levels of fatigue and psychological distress, as well as decreased QoL in patients with an objectively diagnosed venous thromboembolic event. Study participants were 205 consecutively enrolled out-patients (47.4 years, 54.6% men) with DVT and/or PE. Approximately 10 days before blood collection for thrombophilia work-up, QoL, fatigue, and psychological distress were assessed using the Short Form Health Survey (SF-12), the Multidimensional Fatigue Symptom Inventory Short Form (MFSI-SF) as well as the Hospitality Anxiety and Depression scale (HADS). After controlling for demographic and medical factors, fatigue (p<0.01) but not psychological distress (p>0.05) was negatively associated with physical QoL, explaining 11.0% of the variance. Fatigue (p<0.001) and psychological distress (p<0.001) were significant predictors of mental QoL,explaining an additional 36.2% and 3.6% of the variance. Further analyses revealed that all subscales of the HADS (e.g. anxiety and depression) and of the MFSI-SF (e.g. general fatigue, physical fatigue, emotional fatigue, mental fatigue and vigor) were significant predictors of mental QoL. MFSI-SF subscales also predicted physical QoL. The findings suggest that fatigue and psychological distress substantially predict QoL in patients with a previous venous thromboembolic event above and beyond demographic factors.

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Quality of life of patients with breast cancer

Sestrinska rec ◽

10.5937/sestrec2182018k ◽

2021 ◽

Vol 24 (82) ◽

pp. 18-22

Author(s):

Miljana Kuljić ◽

Jelena Ljubomirac ◽

Miloš Radović

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

General Hospital ◽

Short Form ◽

Illness Perception ◽

Depression Scale ◽

University Hospital ◽

Number Of Patients ◽

The University

Introduction: Quality of life represents the overall satisfaction or dissatisfaction with one's own life. Breast cancer is the most common malignant tumor in women in Europe, North America and other Western countries, while its incidence is constantly increasing. Aim: The main aim of the study was to examine the quality of life of patients with breast cancer at the University Hospital Foča and the General Hospital Trebinje. Material and methods: The research was conducted on a sample of 120 patients in the University Hospital Foča and the General Hospital Trebinje from May to August 2019. The chosen study design is the cross-sectional study. A general questionnaire on the basic sociodemographic indicators of the respondents, a modified Short Questionnaire on Health Perception (Brief Illness Perception Questionnaire), a questionnaire on the quality of life SF-36v2 (Short form SF 36 ver 2) and the Beck Depression Scale (BDI) were used in the research. Results: The average value, of the maximum possible 100 points, by which patients assessed their physical component of quality of life is 55.3 points, of which physical functioning was assessed with 52.7 points, limitation due to physical health with 60.5 points, physical pain with 45.3 points and general health with 56.8 points. Beck's depression scale found that the largest number of patients with breast cancer do not have depression, 96 of them (80%), 21 patients (17.5%) have a mild form of depression, 2 patients (1.7%) have moderate depression, while only 1 patient (0,8%) has a severe form of depression. Conclusion: Patients with breast cancer had average values in the domain of the physical and mental component of quality of life. It has been determined that the majority of patients do not have depression.

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Long-term outcome and quality of life after CNS cavernoma resection: eloquent vs. non-eloquent areas

Neurosurgical Review ◽

10.1007/s10143-021-01572-8 ◽

2021 ◽

Author(s):

Loay Shoubash ◽

Jörg Baldauf ◽

Marc Matthes ◽

Michael Kirsch ◽

Matthias Rath ◽

...

Keyword(s):

Quality Of Life ◽

Short Form ◽

Preoperative Evaluation ◽

Patient Counseling ◽

Surgical Morbidity ◽

Term Outcome ◽

Long Term Outcome

AbstractThe aim of this study is to analyze the long-term quality of life after surgery of cavernoma. A monocentric retrospective study was conducted on 69 patients with cavernoma treated microsurgically between 2000 and 2016. The eloquence was adopted from Spetzler-Martin definition. A most recent follow-up was elicited between 2017 and 2019, in which the quality of life (QoL) was evaluated with the Short Form-12 questionnaire (SF12). Forty-one lesions were in eloquent group (EG), 22 in non-eloquent group (NEG), 3 in orbit, and 3 in the spinal cord. Postoperative worsening of the modified Rankin scale (mRS) occurred in 19.5% of cases in EG versus 4.5% in NEG. After a mean follow-up of 6.5 years (SD 4.6), the neurological status was better or unchanged compared to baseline in 85.4% of EG and 100% of NEG. Regarding QoL assessment of 44 patients (EG n = 27, NEG n = 14) attended the last follow-up. Patients after eloquent cavernoma resection reported a non-inferior QoL in most SF12 domains (except for physical role) compared to NEG. However, they reported general health perception inferior to norms, which was affected by the limited physical and emotional roles. At a late follow-up, the surgical morbidity was transient in the NEG and mostly recovered in the EG. The QoL comparison between eloquent and non-eloquent cavernomas created interesting and new data after prolonged follow-up. These results add value for decision-making as well as patient counseling for future encountered cases. Preoperative evaluation of QoL is recommended for future studies to assess QoL dynamics.

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Abstract TP295: Stroke Prevention Surgery > Quality of Life and Cognitive Ability to Drive Are Maintained After Surgical Repair of Unruptured Intracranial Aneurysm

Stroke ◽

10.1161/str.51.suppl_1.tp295 ◽

2020 ◽

Vol 51 (Suppl_1) ◽

Author(s):

Joan M ODonnell ◽

Maurizio Manuguerra ◽

Jemma L Hodge ◽

Greg Savage ◽

Michael K Morgan

Keyword(s):

Quality Of Life ◽

Intracranial Aneurysm ◽

Surgical Management ◽

Cognitive Abilities ◽

Short Form ◽

Unruptured Intracranial Aneurysm ◽

Significant Difference ◽

Ability To Drive

Background: Studies have questioned the effectiveness of surgery for the management of unruptured intracranial aneurysm (uIA). Few studies have examined the ability to drive and quality of life (QOL) after surgery for uIA. Objective: This study examined the effectiveness of surgical management of uIA by measuring patients’ perceived quality of life and their cognitive abilities related to driving. Methods: Between January 2011 and January 2016 patients with a uIA were assessed using the Quality Metric Short Form 36 (SF36) and the off-road driver screening instrument DriveSafeDriveAware. Reassessments were conducted at the 6-week post-operative follow-up for surgical patients and at 12-month follow-up for surgical and conservatively managed patients. Results: 175 patients enrolled in the study, of which 112(66%) had surgical management of their aneurysm. For the surgical cases who completed all assessments (N=74), there was a trend for the DriveSafe pre-operative mean score of 108 (SD 10.7) to be lower than the 6-week and 12-month post-operative mean scores (111 SD 9.7 and 112 SD 10.2 respectively)(p=0.05). There were no significant changes in DriveAware scores at any epoch or between patient groups nor in the MCS in the surgical group.. There was a significant decline in PCS scores at 6 weeks post-operatively which recovered at 12 months (52 SD 8.1, 46 SD 6.8 and 52 SD 7.1 respectively)( p <0.01). There was no significant difference in 12-month mRS scores between the surgical cases who completed with cases who did not complete all assessments. Conclusion: Surgery for uIA did not affect cognitive abilities for driving at 6 weeks or 12 months after surgery. There was a decline in the QOL in the first months after surgery, however QOL returned to pre-surgical status 12 months after surgery. If the risk of seizures is low and there are no post-operative complications, returning to driving can be recommended.

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Abstract 3024: Autogenic Training to Manage Chest pain in Women with Angina and Normal Coronary Arteries.

Circulation ◽

10.1161/circ.116.suppl_16.ii_677-b ◽

2007 ◽

Vol 116 (suppl_16) ◽

Author(s):

Elizabeth A Asbury ◽

Nasim Kanji ◽

Edzard Ernst ◽

Mahmoud Barbir ◽

Peter Collins

Keyword(s):

Quality Of Life ◽

Symptom Severity ◽

Syndrome X ◽

Cardiac Syndrome X ◽

Post Intervention ◽

Health Functioning ◽

Cardiac Syndrome ◽

Symptom Diary

Background: Women with angina pectoris, a positive exercise ECG for myocardial ischaemia and angiographically smooth coronary arteries (Cardiac Syndrome X), suffer increased psychological morbidity, debilitating symptomology and a poor quality of life. Autogenic Training (AT), a hypnosis-based auto-suggestive relaxation technique improved anxiety and quality of life in patients with CHD, multiple sclerosis and breast cancer. An exploration of AT as a treatment for Syndrome X was therefore undertaken. Methods: Fifty three female Syndrome X patients (mean ± SD; 57.4 ± 8.0 yrs) were randomised to an 8-week group-based AT and symptom diary program or symptom diary only control. Weekly group AT sessions were supported by an individual home program. The Hospital Anxiety and Depression Scale (HADS) Spielberger State-Trait Anxiety Inventory (STAI) Cardiac Anxiety Questionnaire (CAQ) and the Ferrans & Powers Quality of Life Index (QLI) were completed pre- and post-intervention and at 8-week follow-up. Results : Post-intervention, AT patients had reduced symptom severity (2.08 ± 1.03 vs. 1.23 ± 1.36, p=0.02) and frequency (6.11 ± 3.17 vs. 1.66 ± 2.19, p<0.001) with improved severity (8.04 ± 10.08 vs. 1.66 ± 2.19, p<0.001) and a trend toward reduced symptom frequency (1.95 ± 1.19 vs. 1.23 ± 1.36, p=0.063) compared to controls. Following AT, improved QLI health functioning (17.80 ± 5.74 vs. 19.41 ± 5.19, p=0.04) and CAQ fear (1.53 ± 0.61 vs. 1.35 ± 0.56, p=0.02) were found, with improvements in QLI health functioning (17.80 ± 5.74 vs. 20.09 ± 5.47, p=0.01), CAQ fear (1.53 ± 0.61 vs. 1.30 ± 0.67, p=0.002) CAQ total (1.42 ± 0.54 vs. 1.29 ± 0.475, p=0.04), STAI trait anxiety (42.95 ± 11.19 vs. 38.68 ± 11.47, p=0.01) and QLI quality of life (20.67 ± 5.37 vs. 21.9 ± 4.89, p=0.02) at follow-up. Post-monitoring changes in HADS depression (5.1 ± 3.3 vs. 4.2 ± 3.2, p=0.01), total HADS (13.95 ± 6.84 vs. 12.22 ± 5.75, p=0.02), CAQ avoidance (1.51 ± 0.92 vs. 1.24 ± 0.89, p=0.03), attention (1.33 ± 0.78 vs. 1.16 ± 0.57. p=0.05) and CAQ total (1.39 ± 0.6 vs. 1.23 ± 0.52, p=0.01) were shown in the control group. None were maintained at follow-up. Conclusion : An 8-week AT program has been shown to improve symptom severity and frequency, psychological morbidity and quality of life in women with Cardiac Syndrome X.

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Does a missed obstetric anal sphincter injury at time of delivery affect short-term functional outcome?

Annals of The Royal College of Surgeons of England ◽

10.1308/rcsann.2017.0140 ◽

2018 ◽

Vol 100 (1) ◽

pp. 26-32 ◽

Cited By ~ 6

Author(s):

L Ramage ◽

C Yen ◽

S Qiu ◽

C Simillis ◽

C Kontovounisios ◽

...

Keyword(s):

Quality Of Life ◽

Anal Sphincter ◽

Short Form ◽

Primary Repair ◽

Obstetric Anal Sphincter Injury ◽

Short Term ◽

Sphincter Injury ◽

Anal Sphincter Injury

Introduction This study aimed to ascertain whether missed obstetric anal sphincter injury at delivery had worse functional and quality of life outcomes than primary repair immediately following delivery. Materials and methods Two to one propensity matching was undertaken of patients presenting to a tertiary pelvic floor unit with ultrasound evidence of missed obstetric anal sphincter injury within 24 months of delivery with patients who underwent primary repair at the time of delivery by parity, grade of injury and time to assessment. Outcomes compared included Birmingham Bowel, Bladder and Urinary Symptom Questionnaire (BBUSQ), Wexner Incontinence Score, Short Form-36, Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire and anorectal physiology results. Results Thirty-two missed anal sphincter injuries were matched two to one with sixty-two patients who underwent primary repair of an anal sphincter defect. Mean time to follow-up was 9.31 ± 6.79 months. Patients with a missed anal sphincter injury had suffered more incontinence, as seen in higher the Birmingham Bowel, Bladder and Urinary Symptom Questionnaire (BBUSQ; 30.56% ± 14.41% vs. 19.75% ± 15.65%, P = 0.002) and Wexner scores (6.00 ± 3.76 vs. 3.67 ± 4.06, P = 0.009). They also had a worse BBUSQ urinary domain score (28.25% ± 14.9% vs. 17.01 ± 13.87%, P = 0.001) and worse physical functioning as measured by the Short Form-36 questionnaire (P = 0.045). There were no differences in other outcomes compared, including anorectal physiology and sexual function. Discussion In the short-term, patients with a missed obstetric anal sphincter injury had significantly worse faecal incontinence and urinary function scores, however quality of life and sexual function were largely comparable between groups. Conclusions Longer-term follow-up is needed to assess the effects of missed obstetric anal sphincter injury over time.

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Coping Strategies and Health-Related Quality of Life in Pregnant Women with SARS-CoV-2 Infection

Medicina ◽

10.3390/medicina57101113 ◽

2021 ◽

Vol 57 (10) ◽

pp. 1113

Author(s):

Madalina Timircan ◽

Felix Bratosin ◽

Iulia Vidican ◽

Oana Suciu ◽

Mirela Turaiche ◽

...

Keyword(s):

Quality Of Life ◽

Pregnant Women ◽

Rural Areas ◽

Short Form ◽

Depression Scale ◽

Morbidity Rate ◽

Cross Sectional ◽

Mortality And Morbidity ◽

Physical Burden

Background and Objectives: As maternal deaths associated with the SARS-CoV-2 infection remain at several times greater than the general population, significant factors that might contribute to the higher mortality and morbidity rate are the psychological impact of the disease and pregnancy itself. Therefore, the current study’s main objective was to assess how pregnant women react and cope with the stress of COVID-19 disease and how it influences their overall health and quality of life in healthcare facilities. Materials and Methods: In this cross-sectional study, we included 304 pregnant women who successfully completed standardized forms to assess our topics of interest, comprising of the Hospital Anxiety and Depression Scale, the Short Form Health Survey-12, the Coping Orientation to Problems Experienced Inventory scale, the CORE-Outcome Measure Questionnaire, and the Quality from the Patient’s Perspective questionnaire. Results: Unemployed, pregnant women living in poverty in the rural areas had higher SARS-CoV-2 infection rates during pregnancy. They faced higher anxiety levels and depression rates, with associated increased physical burden and exhaustion. However, these findings are not influenced by hospital care since it remained unchanged among COVID-19 and non-COVID-19 maternity units, excepting significantly lower technical competence scores of COVID-19 facilities. Conclusions: As the pandemic’s consequences emerge and additional outbreaks occur, care must prioritize the additional physical burden experienced by pregnant women who have contracted COVID-19, as well as psychological, emotional, and mental health support.

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Long-term Neurological Outcome and Quality of Life after World Federation of Neurosurgical Societies Grades IV and V Aneurysmal Subarachnoid Hemorrhage in an Interdisciplinary Treatment Concept

Neurosurgery ◽

10.1093/neuros/nyw138 ◽

2017 ◽

Vol 80 (6) ◽

pp. 967-974 ◽

Cited By ~ 15

Author(s):

Christoph Schwartz ◽

Thomas Pfefferkorn ◽

Caroline Ebrahimi ◽

Caroline Ottomeyer ◽

Gunther Fesl ◽

...

Keyword(s):

Quality Of Life ◽

Functional Outcome ◽

Short Form ◽

Functional Independence ◽

World Federation ◽

Long Term Survivors ◽

Short Form Health

Abstract BACKGROUND: Detailed data on long-term functional outcome of patients with World Federation of Neurosurgical Societies (WFNS) grades IV and V aneurysmal subarachnoid hemorrhages (aSAH) are still scarce. OBJECTIVE: Assessment of long-term outcome of WFNS IV and V aSAH patients. METHODS: Functional outcome and quality of life were assessed by the modified Rankin scale (mRS) and the 36-item short-form health survey in consecutively treated aSAH WFNS IV and V patients between 2005 and 2010. Scores from the 36-item short-form health survey were compared to a healthy German population. Prognostic factors were analyzed by uni- and multivariate models. RESULTS: One hundred and seven eligible patients (median age: 53.0 years) were identified. After interdisciplinary consensus on optimal treatment, aneurysms were obliterated either by clipping (n = 35) or by coiling (n = 72). Ten patients were lost to long-term follow-up; the median clinical follow-up period was 3.2 years for the remaining 97 cases. Twenty-five of 97 died during the acute hospital phase and another 10 patients over the follow-up period leaving 62 long-term survivors. At the end of clinical follow-up, 40/97 patients, including 40/62 of long-term survivors, reached functional independence (mRS ≤ 2). Twelve of 97 patients were moderately (mRS = 3), 10/97 patients were severely disabled (mRS ≥ 4). Younger age (≤ 53 years; P = .001) and radiological absence of cerebral infarction (P = .03) were the strongest predictors for favorable outcome. Quality of life was perceived to be only moderately reduced compared to the healthy control group. CONCLUSION: Poor-grade aSAH is not necessarily associated with poor long-term functional outcome; after aneurysm repair ∼60% of patients survived and among long-term survivors ∼ 60% regained functional independence.

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Conservative treatment of vestibular schwannoma: growth and Penn Acoustic Neuroma Quality of Life scale in French language

Acta Otorhinolaryngologica Italica ◽

10.14639/0392-100x-1094 ◽

2017 ◽

Vol 37 (4) ◽

pp. 320-327

Author(s):

P.A. Oddon ◽

M. Montava ◽

F. Salburgo ◽

M. Collin ◽

C. Vercasson ◽

...

Keyword(s):

Quality Of Life ◽

Acoustic Neuroma ◽

Short Form ◽

Sono State ◽

Sono Stati ◽

Sf 36 ◽

Quality Of Life Scale ◽

Life Scale

Lobiettivo di questo lavoro è stato di valutare la storia naturale di crescita degli schwannomi vestibolari (VS), la qualità di vita di quelli trattati in maniera conservativa e di validare una scala specifica per tale malattia in lingua francese, Penn Acoustic Neuroma Quality-of- Life (PANQOL). Sono stati studiati retrospettivamente 26 pazienti con VS trattato in maniera conservativa. Sono state raccolte le caratteristiche dei pazienti e i reperti radiologici, e sono state utilizzate due scale per validare valutare la qualità di vita: la Short Form-36 Health Survey (SF-36) e la PANQOL scale, tradotta in francese. I punteggi ottenuti sono stati comparati con gli studi precedenti. Il tempo medio di follow up è stato di 25 mesi (range 6-72). È stata osservato un accrescimento del tumore in 14 pazienti (53,8%), nessun accrescimento in 12 pazienti (46,2%), e non si è verificata nessuna riduzione. La crescita media del tumore è stata di 2,22 mm/anno, e non sono stati individuati fattori predittivi di crescita. I pazienti con vertigini e instabilità hanno riferito una più bassa qualità di vita, sia secondo la scala SF-36, sia secondo la scala PANQOL. Utilizzando la scala SF-36, i nostri risultati si sono rivelati paragonabili a quelli della letteratura. Utilizzando la scala PANQOL, i nostri punteggi non si sono rivelati statisticamente diversi da quelli derivanti da studi tedeschi e nordamericani, ad eccezione di quelli riguardanti ludito (p=0,019). La qualità di vita diventa sempre più importante nella gestione dei VS. In linea con questi risultati, noi sosteniamo la strategia non conservativa associata ad una riabilitazione vestibolare per quei pazienti con vertigini ed instabilità. La scala PANQOL, disponibile in lingua francese, si è rivelata specifica per i VS.

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Health-related quality of life in Marfan syndrome: a 10-year follow-up

Health and Quality of Life Outcomes ◽

10.1186/s12955-020-01633-4 ◽

2020 ◽

Vol 18 (1) ◽

Author(s):

Thy Thy Vanem ◽

Svend Rand-Hendriksen ◽

Cathrine Brunborg ◽

Odd Ragnar Geiran ◽

Cecilie Røe

Keyword(s):

Quality Of Life ◽

Marfan Syndrome ◽

Health Survey ◽

Short Form ◽

Physical Domain ◽

Health Related Quality ◽

Related Quality ◽

Health Related

Abstract Background Marfan syndrome, a rare hereditary connective tissue disorder caused by mutations in fibrillin-1, can affect many organ systems, especially the cardiovascular system. Previous research has paid less attention to health-related quality of life and prospective studies on this topic are needed. The aim of this study was to assess changes in health-related quality of life after 10 years in a Norwegian Marfan syndrome cohort. Methods Forty-seven Marfan syndrome patients ≥ 18 years were investigated for all organ manifestations in the 1996 Ghent nosology and completed the self-reported questionnaire, Short-Form-36 Health Survey, at baseline in 2003–2004 and at follow-up in 2014–2015. Paired sample t tests were performed to compare means and multiple regression analyses were performed with age, sex, new cardiovascular and new non-cardiovascular pathology as predictors. Results At 10-year follow-up: a significant decline was found in the physical domain. The mental domain was unchanged. Older age predicted a larger decline in physical health-related quality of life. None of the chosen Marfan-related variables predicted changes in any of the subscales of the Short-Form 36 Health Survey or in the physical or the mental domain. Conclusion Knowledge of decline in the physical domain, not related to organ affections, may be important in the follow-up of Marfan syndrome patients.

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