scholarly journals COVID-19: how a self-monitoring checklist can empower early intervention and slow disease progression

2021 ◽  
Author(s):  
Christopher L. Cummings ◽  
Craig S. Miller
Keyword(s):  
Early Intervention ◽  
Disease Progression ◽  
Slow Disease Progression ◽  
Self Monitoring

scholarly journals Anti-Gag antibodies gag HIV infection and slow disease progression

AIDS ◽  
2018 ◽  
Vol 32 (10) ◽  
pp. 1373-1375 ◽  
Author(s):  
Ali Ahmad ◽  
Vikram Mehraj ◽  
Mohammad-Ali Jenabian ◽  
Jean-Pierre Routy ◽  
Cecile Tremblay
Keyword(s):  
Hiv Infection ◽  
Disease Progression ◽  
Slow Disease Progression

HIV-1 of Children with Slow Disease Progression Escapes Autologous Neutralization and Triggers Development of Cross-neutralizing Responses

2014 ◽  
Vol 30 (S1) ◽  
pp. A98-A98
Author(s):  
Stefania Dispinseri ◽  
Mariangela Cavarelli ◽  
Anna Maria Plebani ◽  
Marianne Jansson ◽  
Gabriella Scarlatti
Keyword(s):  
Disease Progression ◽  
Slow Disease Progression ◽  
Hiv 1

scholarly journals Key to successful treatment of COVID-19: accurate identification of severe risks and early intervention of disease progression

2020 ◽  
Author(s):  
Meizhu Chen ◽  
Changli Tu ◽  
Cuiyan Tan ◽  
Xiaobin Zheng ◽  
Xiaohua Wang ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Early Intervention ◽  
Disease Progression ◽  
Case Fatality Rate ◽  
Severe Disease ◽  
Invasive Mechanical Ventilation ◽  
Case Fatality ◽  
List Type ◽  
Fatality Rate ◽  
Medical Burden

AbstractBackgroundCOVID-19 is a new and highly contagious respiratory disease that has caused global spread, high case fatality rate in severe patients, and a huge medical burden due to invasive mechanical ventilation. The current diagnosis and treatment guidelines are still need to be improved, and more excellent clinical experience is needed to provide reference.MethodsWe analyzed and summarized clinical data of 97 confirmed COVID-19 adult patients (including 26 severe cases) admitted to the Fifth Affiliated Hospital of Sun Yat-sen University from January 17, 2020 to March 10, 2020, included laboratory examination results, imaging findings, treatment effect, prognosis, etc, in order to put forward prediction index of severe COVID-19 patients, principles of early intervention and methylprednisolone usages in COVID-19 patients.ResultsHypoxemia, hyperlactic acid, hypoproteinemia, and hypokalemia were prevalent in COVID-19 patients. The significant low lymphocyte count, hypoproteinemia, hypokalemia, the persistent or worsen high CRP, high D-dimer, and high BNP, and the occurrence of hemoptysis and novel coronavirus (SARS-CoV-2) viremia were important indicators for early diagnosis and prediction of severe disease progression.Characteristic images of lung CT had a clear change in COVID-19, Ground-glass opacity (GGO) and high-density linear combinations may indicate different pathological changes. Rapid lobular progression of GGO suggests the possibility of severe disease.Basic principles of early intervention treatment of COVID-19: on the premise of no effective antiviral drugs, treatment is based on supportive and symptomatic therapy (albumin supplementation, supplement of potassium, supplement blood plasma, etc.) in order to maintain the stability of the intracellular environment and adequately reactivate body immunity to clean up SARS-CoV-2.According to severity, oxygenation index, body weight, age, underlying diseases, appropriate amount methylprednisolone application on severe/critical COVID-19 patients on demand, improved blood oxygen and reduced the utilization rate of invasive mechanical ventilation, case fatality rate and medical burden significantly. The most common indications for invasive mechanical ventilation should be strictly control in critical COVID-19 patients.ConclusionsAccurate and timely identification of clinical features in severe risks, and early and appropriate intervention can block disease progression. 2. Appropriate dose of methylprednisolone can effectively avoid invasive mechanical ventilation and reduce case fatality rate in critical COVID-19 patients.

scholarly journals Slow Disease Progression in a C57BL/6 Pten-Deficient Mouse Model of Prostate Cancer

2011 ◽  
Vol 179 (1) ◽  
pp. 502-512 ◽  
Author(s):  
Robert U. Svensson ◽  
Jessica M. Haverkamp ◽  
Daniel R. Thedens ◽  
Michael B. Cohen ◽  
Timothy L. Ratliff ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mouse Model ◽  
Disease Progression ◽  
Deficient Mouse ◽  
Slow Disease Progression

Early intervention in bipolar disorders

2019 ◽  
pp. 145-166
Author(s):  
Gin S. Malhi ◽  
Grace Morris ◽  
Amber Hamilton ◽  
Tim Outhred
Keyword(s):  
Bipolar Disorder ◽  
Early Intervention ◽  
Disease Progression ◽  
Bipolar Disorders ◽  
Intervention Strategies

The concept of early intervention for bipolar disorder (BD) is both attractive and logical as there is often a considerable delay between the onset of BD symptoms and diagnosis. This chapter addresses key definitional and conceptual considerations for early intervention in BD and exposes the expansive gaps in our knowledge of the phenomenology of BD, prognostication, and disease progression and trajectory. These gaps highlight that early intervention for BD—in terms of treatment specificity and timing—is far from being realised. There are though significant risks associated with implementing early intervention strategies at this stage, which may range from unnecessarily prescribing potentially harmful medication to perhaps inadvertently accelerating the progression of the illness. Until there are major scientific and clinical advancements, this chapter provides a conservative yet involved approach for early intervention in BD.

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