Physicochemical characteristics of thermo-responsive gelatin membranes containing carboxymethyl chitosan and poly(N-isopropylacrylamide-co-acrylic acid)

2021 ◽  
Vol 28 (5) ◽  
Author(s):  
Yi-Cheng Huang ◽  
Chia-Tien Lee ◽  
Trong-Ming Don
Keyword(s):  
Acrylic Acid ◽  
Physicochemical Characteristics ◽  
Carboxymethyl Chitosan

Physicochemical characteristics of acrylic-acid polymer-impregnated cement pastes

1995 ◽  
Vol 62 (3) ◽  
pp. 310-316
Author(s):  
E. A. M. Gad ◽  
M. M. A. El-Sukkary ◽  
W. M. Sayed ◽  
S. A. Abo-El-Enein
Keyword(s):  
Acrylic Acid ◽  
Physicochemical Characteristics ◽  
Cement Pastes

Synthesis of carboxymethyl-chitosan/acrylic acid hydrogel using silane crosslinker

e-Polymers ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Tariq Yasin ◽  
Nadia Rasool ◽  
Zareen Akhter
Keyword(s):  
Drug Delivery ◽  
Aqueous Solution ◽  
Small Intestine ◽  
Acrylic Acid ◽  
Low Ph ◽  
Carboxymethyl Chitosan ◽  
Mass Ratio ◽  
Pyranose Ring ◽  
Ir Analysis ◽  
The Stability

AbstractNovel pH sensitive carboxymethyl (CM) chitosan/acrylic acid hydrogels were prepared. CM-chitosan and acrylic acid (AA) in aqueous solution were copolymerized and crosslinked by using vinyltriethoxysilane (VTESi). Different amounts of AA and crosslinker were incorporated in CM-chitosan/AA hydrogel. IR analysis confirmed the presence of pyranose ring as well as Si-O-Si linkage within the hydrogel. Thermogravimetric analysis showed an increase in the stability of hydrogel either having high AA ratio or high crosslinker ratio. The swelling of the hydrogels was carried out by investigating the effect of time, pH (buffered and nonbuffered) and ionic media. In non-buffered media the overall swelling was found to be high as compared to buffered media. Maximum swelling was observed in hydrogel having mass ratio of 7.0 (AA : CM-chitosan). This hydrogel showed low swelling in low pH similar to that of the stomach and high swelling in neutral pH similar to that of the small intestine and can be used in drug delivery applications

scholarly journals Highly Porous pH-Responsive Carboxymethyl Chitosan-Grafted-Poly (Acrylic Acid) Based Smart Hydrogels for 5-Fluorouracil Controlled Delivery and Colon Targeting

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Samiullah Khan ◽  
Naveed Anwar
Keyword(s):  
Colon Cancer ◽  
Acrylic Acid ◽  
General Circulation ◽  
Structural Parameters ◽  
Oral Route ◽  
Carboxymethyl Chitosan ◽  
Release Mechanism ◽  
Circulation Current ◽  
Model Drug ◽  
Model Equations

In the present investigation, new formulations of CMCS/AA hydrogels with varying composition of Carboxymethyl chitosan, acrylic acid, and ethylene glycol dimethacrylate (EGDMA) were prepared by free radical polymerization technique using benzoyl peroxide as catalyst. The bioavailability of 5-FU through the oral route is very limited owing to its rapid metabolism and clearance from the general circulation. Current work was aimed at increasing the bioavailability of 5-FU via smart hydrogels and at investigating their potential in delivering 5-FU to target colon cancer. Swelling studies were carried out on dried hydrogel discs in different USP phosphate buffer solutions of various pH values. Porosity and gel fraction of all the samples were measured. 5-FU was used as a model drug and loaded in selected hydrogel samples. The amount of drug loaded and released was determined. Experimental data was fitted to various model equations, and corresponding parameters were calculated to study the release mechanism. Many structural parameters were calculated. The prepared hydrogels were also characterized by FTIR and SEM to study the structure, crystallinity, compatibility, and morphology of the smart hydrogels. The biocompatibility and cytotoxic potential blank and drug-loaded hydrogels were assessed through MTT assay. The prepared hydrogels were found to be an excellent carrier for 5-FU in targeting colon cancer.

scholarly journals Synthesis of N-vinylpyrrolidone/Acrylic acid nanoparticles for drug delivery: Method optimization

2018 ◽  
Vol 192 ◽  
pp. 01020 ◽  
Author(s):  
Chaiyakarn Pornpitchanarong ◽  
Theerasak Rojanarata ◽  
Praneet Opanasopit ◽  
Prasopchai Patrojanasophon ◽  
Tanasait Ngawhirunpat
Keyword(s):  
Drug Delivery ◽  
Acrylic Acid ◽  
Polymeric Nanoparticles ◽  
Drug Carrier ◽  
Synthesis Method ◽  
Physicochemical Characteristics ◽  
Vinyl Pyrrolidone ◽  
Molar Ratio ◽  
Negative Surface ◽  
Drug Nanocarriers

There are various approaches to deliver therapeutic agents to the preferred target. Polymeric nanoparticles were found to have pleasing suitability as a drug carrier. The goal of this research was to optimize the synthesis method to obtain the desirable %yield and particle properties of the new biocompatible polymer-based nanoparticles. The non-toxic polymer, N-vinyl pyrrolidone (NVP) and a widely used hydrophilic biocompatible acrylic acid (AA) monomer were used to form the drug nanocarriers. The synthesis method was optimized by changing the types of initiator (KPS or V50) and the monomers molar ratio (NVP:AA). It was found that by varying both the monomer molar ratio and the type of reaction initiator, did not have significant effect on the physicochemical characteristics of the nanocarriers. The FTIR spectra of all products exhibited the peaks of carboxylic acid, carbonyl, and tertiary amine functional group vibration. The particle size of the nanocarriers was in the range of 173.6 ± 18.4 to 201.4 ± 17.1 nm with negative surface charge. However, the yield obtained increased as the initiator was altered from KPS to V50, and when the acrylic acid molar ratio was increased from 1:1 to 1:3. In conclusion, changing the initiator and monomer molar ratio may affect the physicochemical properties of the nanocarriers and the %yield of the nanocarrier product. Further investigations are essential to obtain the favorable drug nanocarriers for drug delivery.

Novel polymeric composites based on carboxymethyl chitosan and poly(acrylic acid): in vitro and in vivo evaluation

2017 ◽  
Vol 28 (10) ◽  
Author(s):  
Qurat-ul-Ain Sharif ◽  
Muhammad Sohail ◽  
Mahmood Ahmad ◽  
Muhammad Usman Minhas ◽  
Shahzeb Khan ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Polymeric Composites ◽  
Carboxymethyl Chitosan ◽  
In Vivo Evaluation ◽  
Poly Acrylic Acid
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