Health-related quality of life among breast cancer patients compared to cancer survivors and age-matched women in the general population in Vietnam

Abstract Purpose This study compared the health-related quality of life (HRQoL) of breast cancer (BC) patients, survivors, and age-matched women from the general population in Vietnam to address the paucity of HRQoL research and contribute to the robust assessment of BC screening and care in Vietnam. Methods The standardised EQ-5D-5L instrument was incorporated in an online survey and a hospital-based face-to-face survey, and together with data from the Vietnam EQ-5D-5L norms study. χ2 tests assessed EQ-5D health profile associations and a Tobit regression model investigated the association between overall health status (EQ-VAS/utility scores) and sociodemographic and clinical characteristics. Results A total of 309 participants (107 patients undergoing treatment and 202 survivors who had completed treatment) provided usable responses. The dimensions that affected mostly the HRQoL of women with BC were pain/discomfort and anxiety/depression. Current patients and survivors differed significantly regarding HRQoL dimensions of mobility, self-care, usual activities, and anxiety/depression. Their health utilities were 0.74 and 0.84, respectively, compared with 0.91 for age-matched Vietnamese women in the general population (p < 0.001). Treatment status (survivor vs patient), younger age, higher monthly household income, and higher education levels were associated with higher health utility. Conclusions The results point to unmet needs in mental health support and well-being and for attention to be given to the development of a biopsychosocial system of cancer diagnosis, treatment, and care. The results will also inform future assessments of the comparative value for money of interventions intended to impact on breast cancer in Vietnam.

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Health-related quality of life among breast cancer patients compared to cancer survivors and age-matched women in the general population in Vietnam

10.21203/rs.3.rs-120435/v1 ◽

2020 ◽

Author(s):

Tran Thu Ngan ◽

Vu Quynh Mai ◽

Hoang Van Minh ◽

Michael Donnelly ◽

Ciaran O’Neill

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

General Population ◽

Online Survey ◽

Well Being ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Anxiety Depression

Abstract Background This study compared the health-related quality of life (HRQoL) of BC patients, survivors, and age-matched women from the general population in Vietnam in order to address the paucity of HRQoL research and contribute to the robust assessment of breast cancer (BC) screening and care in Vietnam. Methods The standardised EQ-5D-5L instrument was incorporated in an online survey and a hospital-based face-to-face survey, and together with data from the Vietnam EQ-5D-5L norms Study. χ2 tests assessed EQ-5D health profile associations and a Tobit regression model investigated the association between overall health status (EQ-VAS/utility scores) and sociodemographic and clinical characteristics. Results A total of 309 participants (107 patients undergoing treatment and 202 survivors who had completed treatment) provided usable responses. The dimensions that affected most the HRQoL of women with BC were pain/discomfort and anxiety/depression. Current patients and survivors differed significantly regarding HRQoL dimensions of mobility, self-care, usual activities, and anxiety/depression. Their health utilities were 0.74 and 0.84, respectively, compared with 0.91 for age-matched Vietnamese women in the general population (p < 0.001). Treatment status (survivor vs patient), younger age, higher monthly household income, and higher education levels were associated with higher health utility. Conclusions The results point to unmet needs in mental health support and well-being and for attention to be given to the development of a biopsychosocial system of cancer diagnosis, treatment, and care. The results will also inform future assessments of the comparative value for money of interventions intended to impact on breast cancer in Vietnam.

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Correlates of existential well-being and their association with health-related quality of life in breast cancer survivors compared with the general population

Breast Cancer Research and Treatment ◽

10.1007/s10549-009-0326-0 ◽

2009 ◽

Vol 118 (1) ◽

pp. 139-150 ◽

Cited By ~ 15

Author(s):

Hae Won Shin ◽

Dong Young Noh ◽

Eun Sook Lee ◽

Seok Jin Nam ◽

Byeong Woo Park ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

General Population ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Well Being ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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A comparison of the clinical determinants of health-related quality of life and subjective well-being in long-term breast cancer survivors

European Journal of Cancer Care ◽

10.1111/j.1365-2354.2012.01344.x ◽

2012 ◽

Vol 21 (5) ◽

pp. 692-700 ◽

Cited By ~ 14

Author(s):

P. TESSIER ◽

S. LELORAIN ◽

A. BONNAUD-ANTIGNAC

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Breast Cancer Survivors ◽

Well Being ◽

Subjective Well Being ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Improvements in Health-Related Quality of Life of Patients with DLBCL after Treatment with Yttrium-90 Ibritumomab Tiuxetan (90y-Zevalin).

Blood ◽

10.1182/blood.v106.11.4794.4794 ◽

2005 ◽

Vol 106 (11) ◽

pp. 4794-4794

Author(s):

S. S. Thompson ◽

S. Macran ◽

J. Kalmus ◽

F. Morschhauser

Keyword(s):

Quality Of Life ◽

B Cell Lymphoma ◽

Well Being ◽

Maximal Response ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Anxiety Depression ◽

The Impact

Abstract PURPOSE: This health-related quality of life (HRQL) study aimed to evaluate the impact of 90y-Zevalin therapy on the HRQL of older patients with relapsed diffuse large B-cell lymphoma (DLBCL) not eligible for stem cell transplantation. Ppsychometric performance of the FACT-G and EQ-5D in the same patient sample was also evaluated. The study was conducted alongside a single arm, phase II clinical trial of 90Y-Zevalin radioimmunotherapy. METHODS: The FACT-G scale contains 27 questions, grouped according to 4 “dimensions” of HRQL relevant to patients with cancer: Physical, Functional, Social and Emotional well-being. The scale provides a total score for overall HRQL and subscale scores for each dimension. The EQ-5D is a generic measure of HRQL used in a range of diseases and comprises a descriptive classification based on 5 broad dimensions and a visual analogue scale. Data from the 2 measures were analyzed with descriptive statistics. Validity was assessed in terms of correlations between individual dimensions. Changes in the dimensions and total scores of the FACT-G and EQ-5D from baseline to wk 12 post-90Y-Zevalin therapy were assessed using paired t-tests. Wk 12 corresponded to the time of expected maximal response to 90Y-Zevalin therapy. RESULTS: Sixty-six of 104 patients enrolled in the clinical study completed the FACT-G and EQ-5D questionnaires at baseline and 35 completed the questionnaires at wk 12. Those who completed the questionnaires at both baseline and wk 12 were more likely to have responded to 90Y-Zevalin (80% were responders) although they were comparable in terms of age (median = 72 yrs) and gender (54% male) to those who only completed the questionnaires at baseline. At baseline, the dimensions of HRQL with the worst scores and therefore most affected by DLBCL, included areas related to energy, pain, anxiety and depression, which would be expected given the symptoms commonly associated with DLBCL such as fatigue. The percentage of patients reporting “some or extreme problems” on each of the EQ-5D dimensions at baseline are summarized in the table. Moderate correlations were observed between the Physical Well-being of the FACT-G and the Usual Activities (=0.60) and Pain/Discomfort (=0.70) dimensions of the EQ-5D. The Emotional Well-being dimension of the FACT-G was moderately correlated with the Anxiety/Depression on the EQ-5D (=0.66). These data suggest the FACT-G and the EQ-5D were measuring some common concepts to patients. All summary dimensions of the FACT-G and EQ-5D showed either a positive trend or little change after treatment with 90Y-Zevalin, with the Physical Well-being dimension of the FACT-G reaching statistical significance (P=0.03) and measuring a 10% improvement over baseline. The change in total score of the FACT-G almost reached significance (P=0.06), as did the emotional dimension of the FACT-G (P=0.10) and the mobility dimension of the EQ-5D (P=0.08). CONCLUSION: Although number of participating patients was small, the EQ-5D and the FACT-G have demonstrated validity for patients with DLBCL following treatment with 90Y-Zevalin. The greatest impact of 90Y-Zevalin therapy is an improvement in physical well-being, with an increased level of energy, reduced amount of pain and reduced level of “feeling ill”. EQ-5D dimension % of patients reporting “Some or extreme problems” at baseline Mobility 26 Self-care 12 Usual activities 29 Pain/discomfort 54 Anxiety/depression 58

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Health related quality of life among postmenopausal woman with hormone responsive HER2− breast cancer in Indonesia

Journal of Basic and Clinical Physiology and Pharmacology ◽

10.1515/jbcpp-2020-0427 ◽

2021 ◽

Vol 32 (4) ◽

pp. 561-565

Author(s):

Ria Etikasari ◽

Tri Murti Andayani ◽

Dwi Endarti ◽

Kartika Widayati Taroeno-Hariadi

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Postmenopausal Women ◽

Utility Score ◽

Health State ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Anxiety Depression

Abstract Objectives Breast cancer (BC) in women could decrease health-related quality of life (HRQoL). HRQoL becomes important to be assessed to design a relevant treatment that could improve patient outcomes. Furthermore, assessing HRQoL by measuring health state utilities becomes pivotal for health economic evaluation. This study aimed to describe the HRQoL of postmenopausal women with hormone responsive (HR+) HER2− BC using the EQ5D5L instrument in Indonesia. Methods A cross-sectional study was conducted among 126 patients in Dr. Sardjito Hospital in Indonesia. The HRQoL was assessed by interviewing BC patients using the EQ5D5L questionnaire, and the utility index was calculated using the Indonesian value set. Information regarding clinical characteristic and socio-demographic were gained from patient medical records. One-way ANOVA and post-hoc Scheffe’s test was performed to compare the utility score within the health state. Results Of the 126 patients, a mean ± SD for the age of 59.2 ± 6.1 years. The major problems of patients were pain/discomfort (75.4%) followed by anxiety/depression (54.8%). The mean (SD) of EQ5D VAS was 76.64 (14.91). Mean (SD) of utility score was 0.87 (0.10), 0.77 (0.19) and 0.58 (0.44) for free metastasis (FM), locoregional metastasis (LM) and distant metastasis (DM), respectively. Poor QoL was observed at DM health state (p<0.05). Conclusions HRQoL of postmenopausal women with HR+ HER2− BC was low. The major reported problems were pain/discomfort and anxiety/depression.

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