scholarly journals Quantitative Rodent Brain Receptor Imaging

2019 ◽  
Vol 22 (2) ◽  
pp. 223-244 ◽  
Author(s):  
Kristina Herfert ◽  
Julia G. Mannheim ◽  
Laura Kuebler ◽  
Sabina Marciano ◽  
Mario Amend ◽  
...  
Keyword(s):  
Receptor Imaging ◽  
Rodent Brain ◽  
Brain Receptor

scholarly journals In vitro Pharmacological Profile of 3-N-(2-Fluoroethyl)Spiperone

1990 ◽  
Vol 10 (1) ◽  
pp. 140-142 ◽  
Author(s):  
André M. Goffinet ◽  
Josée Leysen ◽  
Daniel Labar
Keyword(s):  
Adrenergic Receptors ◽  
Binding Affinities ◽  
Pharmacological Profile ◽  
High Affinity ◽  
Monoamine Release ◽  
Rodent Brain ◽  
Receptor Sites ◽  
Uptake Sites ◽  
Brain Receptor

The binding affinities of spiperone and 3-N-(2-fluoroethyl)spiperone (FESP) have been compared for several rodent brain receptor sites and for inhibition of monoamine release and uptake sites. FESP and spiperone have almost identical profiles, namely a high affinity for dopamine-D2 and serotonin-S2 receptors, a low affinity for α1-adrenergic receptors, and negligible binding to other sites. These results suggest that available data on spiperone binding may be applied to the interpretation of PET data obtained with FESP.

The simplified reference tissue model for SPECT/PET brain receptor studies

2008 ◽  
Vol 47 (04) ◽  
pp. 167-174 ◽  
Author(s):  
F. Thiele ◽  
R. Buchert
Keyword(s):  
Region Of Interest ◽  
Compartment Model ◽  
Receptor Imaging ◽  
Reference Tissue ◽  
Time Activity ◽  
Tissue Model ◽  
Activity Curve ◽  
Reference Tissue Model ◽  
Simplified Reference Tissue Model ◽  
Brain Receptor

SummaryAim: The SRTM (simplified reference tissue model) of brain receptor imaging assumes that the time activity curve in the receptor-rich region of interest can be fitted satisfactorily by the 1-tissue compartment model. This assumption has been formulated by a rather restrictive constraint on the rate constants. Empirically, the SRTM might well describe also tracers which do not fulfil this constraint, such as [11C]raclopride, for example. However, this has not been justified rigorously. Methods: The requirements for the SRTM to be applicable are analyzed in detail. Results: The SRTM is applicable under a less restrictive constraint than described previously. The interpretation of the SRTM parameters R1 and K2 in physiological terms depends on the constraint, while the interpretation of BPND does not. Conclusion: Correct interpretation of the results of the SRTM is tracer specific. In particular, the parameter R1, which in case of compliance with the original constraint might be used to detect perfusion and/or extraction effects, might not be appropriate for this purpose in case of raclopride-like tracers.

Fractal analysis – a new approach in brain receptor imaging

1998 ◽  
Vol 30 (3) ◽  
pp. 242-248 ◽  
Author(s):  
Jyrki Kuikka ◽  
Jari Tiibonen
Keyword(s):  
Fractal Analysis ◽  
Receptor Imaging ◽  
New Approach ◽  
Brain Receptor

Progress of In Vivo Electroporation in the Rodent Brain

2014 ◽  
Vol 14 (3) ◽  
pp. 211-217 ◽  
Author(s):  
Xue-Feng Ding ◽  
De-Lin Ma ◽  
Qiang Zhang ◽  
Wei Peng ◽  
Ming Fan ◽  
...  
Keyword(s):  
In Vivo Electroporation ◽  
Rodent Brain

scholarly journals Histological characterization and quantification of newborn cells in the adult rodent brain

2021 ◽  
Vol 2 (3) ◽  
pp. 100614
Author(s):  
Charlotte M. Ermine ◽  
Carolina A. Chavez ◽  
Lachlan H. Thompson
Keyword(s):  
Rodent Brain
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