Potential innovation against Alzheimer’s disorder: a tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its intranasal delivery

Tree nuts and peanuts are healthy foods with a proven track record of helping to reduce the incidence of chronic diseases, most notably cardiovascular disease. At the point of consumption, all nuts contain low moisture and ≥ 50% lipid contents, but this is where similarities end. The levels of key nutrients and bioactives including vitamin C, vitamin E, L-arginine, minerals (such as selenium and zinc), and phenolics can differ markedly. Distinctions in the types and quantities of phenolic constituents for tree nut species, as well as the impact of digestion, will affect the nuts’ antioxidant potential in vivo. This work provides some insight into the different types of phenolics found in tree nuts and peanuts, the antioxidant potential of their phenolic extracts using in vitro chemical assays, the effect of thermal processing on the stability of the nuts’ endogenous phenolics, and the impact on biomarkers of human health arising from randomized clinical trials. Key biomarkers include measures in the reduction of LDL oxidation as well as increases in the levels of vitamin E and selected phenolic compounds in blood plasma postprandially from those of baseline.

Download Full-text

Rhanterium suaveolens, Vitamin E and C Pretreatment Prevents Valproic Acid Induced Renal Oxidant Damage

The Natural Products Journal ◽

10.2174/2210315510999200629205136 ◽

2020 ◽

Vol 10 ◽

Author(s):

Amel Amrani ◽

Ouahiba Benaissa ◽

Nassima Boubekri ◽

Fadila Benayache ◽

Samir Benayache ◽

...

Keyword(s):

Oxidative Stress ◽

Valproic Acid ◽

Vitamin E ◽

Serum Creatinine ◽

Natural Antioxidants ◽

Control Group ◽

Protective Effects ◽

Butanol Extract ◽

Renal Tubular ◽

Vit C

Background: Long-term administration of valproic acid (VPA) is known to promote renal tubular injury mediated by increase in renal oxidative stress. Recent evidence indicates that natural antioxidants are alternative to attenuate oxidative stress and kidney damage. Objective: This study was performed to investigate the protective effects of n-butanol extract of Rhanterium suaveolens, vitamin E (Vit E) and vitamin C (Vit C) against VPA induced nephrotoxicity in mice. Methods: Mice were randomly divided into 6 groups (n: 8) and treated daily for 12 days. They received VPA (300 mg/kg intraperitoneally (ip)), buthanolic extract (100 mg/kg), Vit E (100 mg/kg), and Vit C (16.66 mg/kg) 1h prior to administration of VPA. On day 13, blood and Kidneys samples were analyzed for biomarker levels and histopathological changes. Kidneys homogenates were used for determination of oxidative stress parameters that include malondialdehyde (MDA), glutathione (GSH) level and glutathione peroxidase (GPx) activity. Result: Treatment with VPA showed a significant increase in the levels of serum creatinine, urea and malondialdehyde (MDA) and decreasing the enzymatic activity (GPx) as well as GSH levels in kidney with marked necrotic epithelial cells and infiltration in kidney sections as compared to the control group. Pretreatment with the n-butanol extract of R. suaveolens, Vit C or Vit E 1 h prior to administration of VPA showed a significant decrease in the levels of serum creatinine, urea, and MDA, as well as an improvement in the antioxidant elements and histological changes compared to those previously seen in the group treated with VPA alone. Conclusion: It is concluded that n-butanol extract of R. suaveolens, Vit C and Vit E pretreatment effectively improved renal function and tissue oxidative damage caused by VPA.

Download Full-text

Dietary Antioxidant Vitamins and Minerals and Breast Cancer Risk: Prospective Results from the SUN Cohort

Antioxidants ◽

10.3390/antiox10030340 ◽

2021 ◽

Vol 10 (3) ◽

pp. 340

Author(s):

Cesar I. Fernandez-Lazaro ◽

Miguel Ángel Martínez-González ◽

Inmaculada Aguilera-Buenosvinos ◽

Alfredo Gea ◽

Miguel Ruiz-Canela ◽

...

Keyword(s):

Breast Cancer ◽

Vitamin E ◽

Proportional Hazards ◽

Natural Antioxidants ◽

Cox Proportional Hazards ◽

University Graduates ◽

Inverse Association ◽

The Sun ◽

Dietary Intakes

There is growing interest in natural antioxidants and their potential effects on breast cancer (BC). Epidemiological evidence, however, is inconsistent. We prospectively evaluated the association between dietary intake of vitamins A, C, and E, selenium, and zinc and BC among 9983 female participants from the SUN Project, a Mediterranean cohort of university graduates. Participants completed a food frequency questionnaire at baseline, and biennial follow-up information about incident BC diagnosis was collected. Cases were ascertained through revision of medical charts and consultation of the National Death Index. Cox proportional hazards models were used to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CI). During an average follow-up of 11.3 years, 107 incident BC cases were confirmed. The multivariable HRs (95% CI) for BC comparing extreme tertiles of energy-adjusted dietary intakes were 1.07 (0.64–1.77; Ptrend = 0.673) for vitamin A, 1.00 (0.58–1.71; Ptrend = 0.846) for vitamin C, 0.92 (0.55–1.54; Ptrend = 0.728) for vitamin E, 1.37 (0.85–2.20; Ptrend = 0.135) for selenium, and 1.01 (0.61–1.69; Ptrend = 0.939) for zinc. Stratified analyses showed an inverse association between vitamin E intake and postmenopausal BC (HRT3 vs. T1 = 0.35; 95% CI, 0.14–0.86; Ptrend = 0.027). Our results did not suggest significant protective associations between dietary vitamins A, C, and E, selenium, or zinc and BC risk.

Download Full-text

Emulgel Formulation of Purified Extract of Moringa (Moringa oleifera L.) Leaf

Folia Medica Indonesiana ◽

10.20473/fmi.v55i1.24329 ◽

2021 ◽

Vol 55 (1) ◽

pp. 17

Author(s):

Tutik Wuryandari ◽

Nining Sugihartini ◽

Kintoko Kintoko

Keyword(s):

Vitamin E ◽

Leaf Extract ◽

Moringa Oleifera ◽

Physical Property ◽

Natural Antioxidants ◽

Ash Content ◽

Physical Characteristics ◽

Extract Concentration ◽

Moringa Leaf Extract

Moringa oleifera, known as moringa, is reported to have a high source of natural antioxidants, especially vitamin E. The formulation of purified Moringa leaf extract is needed so that the vitamin E content in it is more maximal. This study aimed to determine the levels of vitamin E in extracts after purification, physical property test of emulgel with variations in extract concentration and vitamin E levels in emulsions. The study was started from the extraction using maceration method with petroleum ether solvent, followed by extract purification using column chromatography with n-hexane solvent. The results of the purified extract were then formulated into emulgel with three concentrations of 3% (F1), 6% (F2) and 9% (F3). Emulgel was then evaluated for physical characteristics (pH, viscosity, adhesion, dispersion and stability). Determination of vitamin E levels was carried out on purified extract samples and on each formula. The results of non-specific standardization of extracts included ash content, acidic insoluble ash content were higher than those of Indonesian Herbal Pharmacopoeia literature and drying losses were lower compared to literature. Specific standardization of extracts was the content of vitamin E in 1.40% PE extract and 8.02% purified extract. In the test of emulgel physical characteristics, an increase in the concentration of the extract caused an increase in viscosity and decreased emulgel dispersion power. Whereas, tthe pH and sticky power remained the same. Storage hds an effect on decreasing the physical characteristics of emulsions especially on adhesion. Increased extracts also caused an increase in the levels of vitamin E in the purified extract of moringa leaf emulgel.

Download Full-text

The Antioxidant Properties of Selenium and Vitamin E; Their Role in Periparturient Dairy Cattle Health Regulation

Antioxidants ◽

10.3390/antiox10101555 ◽

2021 ◽

Vol 10 (10) ◽

pp. 1555

Author(s):

Jianxin Xiao ◽

Muhammad Zahoor Khan ◽

Yulin Ma ◽

Gibson Maswayi Alugongo ◽

Jiaying Ma ◽

...

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

Dairy Cattle ◽

Antioxidant System ◽

Antioxidant Properties ◽

Natural Antioxidants ◽

The Body ◽

Late Gestation ◽

Ros Production ◽

Antioxidant Agents

Dairy cattle experience health risks during the periparturient period. The continuous overproduction of reactive oxygen species (ROS) during the transition from late gestation to peak lactation leads to the development of oxidative stress. Oxidative stress is usually considered the main contributor to several diseases such as retained placenta, fatty liver, ketosis, mastitis and metritis in periparturient dairy cattle. The oxidative stress is generally balanced by the naturally available antioxidant system in the body of dairy cattle. However, in some special conditions, such as the peripariparturient period, the natural antioxidant system of a body is not able to balance the ROS production. To cope with this situation, the antioxidants are supplied to the dairy cattle from external sources. Natural antioxidants such as selenium and vitamin E have been found to restore normal health by minimizing the harmful effects of excessive ROS production. The deficiencies of Se and vitamin E have been reported to be associated with various diseases in periparturient dairy cattle. Thus in the current review, we highlight the new insights into the Se and vitamin E supplementation as antioxidant agents in the health regulation of periparturient dairy cattle.

Download Full-text

The importance of antioxidants in the protection against mycotoxicoses in farm animals

Zbornik Matice srpske za prirodne nauke ◽

10.2298/zmspn1120261j ◽

2011 ◽

pp. 261-268

Author(s):

Mirjana Joksimovic-Todorovic ◽

Vesna Davidovic

Keyword(s):

Free Radicals ◽

Vitamin E ◽

Biological Activities ◽

Animal Health ◽

Natural Antioxidants ◽

Biologically Active ◽

Farm Animals ◽

Physiological Age ◽

Peroxidation Of Lipids ◽

Parasitic Fungi

Mycotoxins are biologically active substances that are synthesized by saprophytic and parasitic fungi, and which, when taken into organism by ingestion, can provoke intoxications known as mycotoxicoses. Farm animals show different susceptibility to mycotoxins depending on various factors: genetic (species and breeds), physiological (age and obesity) and environmental (hygienic and climatic). One of the mechanisms of mycotoxin activities is peroxidation of lipids brought about directly by the production of free radicals or by increased sensitivity of tissue to peroxidation. Peroxidation of lipids provoked by mycotoxins is caused by low level of natural antioxidants, so they have a crucial role in the protection against mycotoxins. Nutritive stress can influence negatively the relationship between antioxidants/pro-oxidants, and mycotoxins are nowadays regarded as leading factors of stress induced by nutrition. This optimal relationship can be regulated by the use of antioxidants in food (selenium, vitamin E, carotenoids, etc.) known to prevent tissue damages caused by free radicals. Selenium and vitamin E are essential nutrients which contribute to the preservation of animal health by realizing mutual biological activities in the organism. This paper presents the findings on mechanisms of the action of different species of mycotoxins and the importance of antioxidative protection in farm animals, as well as the results of our investigations of influence of mycotoxins on the occurrence of some reproductive disorders in pigs.

Download Full-text

The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids

Environmental Toxicology and Pharmacology ◽

10.1016/s1382-6689(02)00003-0 ◽

2002 ◽

Vol 11 (3-4) ◽

pp. 321-333 ◽

Cited By ~ 203

Author(s):

Ivonne M.C.M. Rietjens ◽

Marelle G. Boersma ◽

Laura de Haan ◽

Bert Spenkelink ◽

Hanem M. Awad ◽

...

Keyword(s):

Vitamin E ◽

Vitamin C ◽

Natural Antioxidants

Download Full-text

A Regenerative Antioxidant Protocol of Vitamin E andα-Lipoic Acid Ameliorates Cardiovascular and Metabolic Changes in Fructose-Fed Rats

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2011/120801 ◽

2011 ◽

Vol 2011 ◽

pp. 1-8 ◽

Cited By ~ 14

Author(s):

Jatin Patel ◽

Nur Azim Matnor ◽

Abishek Iyer ◽

Lindsay Brown

Keyword(s):

Type 2 Diabetes ◽

Vitamin E ◽

Lipoic Acid ◽

Fixed Combination ◽

Natural Antioxidants ◽

Collagen Deposition ◽

Cardiovascular Damage ◽

Male Wistar Rats ◽

Tocotrienol Rich Fraction

Type 2 diabetes is a major cause of cardiovascular disease. We have determined whether the metabolic and cardiovascular changes induced by a diet high in fructose in young adult male Wistar rats could be prevented or reversed by chronic intervention with natural antioxidants. We administered a regenerative antioxidant protocol using two natural compounds:α-lipoic acid together with vitamin E (α-tocopherol alone or a tocotrienol-rich fraction), given as either a prevention or reversal protocol in the food. These rats developed glucose intolerance, hypertension, and increased collagen deposition in the heart together with an increased ventricular stiffness. Treatment with a fixed combination of vitamin E (eitherα-tocopherol or tocotrienol-rich fraction, 0.84 g/kg food) andα-lipoic acid (1.6 g/kg food) normalized glucose tolerance, blood pressure, cardiac collagen deposition, and ventricular stiffness in both prevention and reversal protocols in these fructose-fed rats. These results suggest that adequate antioxidant therapy can both prevent and reverse the metabolic and cardiovascular damage in type 2 diabetes.

Download Full-text