scholarly journals The Role of Movement Patterns in Epidemic Models on Complex Networks

2021 ◽  
Vol 83 (10) ◽  
Author(s):  
Alfonso Ruiz-Herrera ◽  
Pedro J. Torres
Keyword(s):  
Complex Networks ◽  
Network Theory ◽  
Diffusion Rate ◽  
Critical Role ◽  
Movement Patterns ◽  
Epidemic Models ◽  
Simplifying Assumptions ◽  
The Common

AbstractIn this paper, we analyze the influence of the usual movement variables on the spread of an epidemic. Specifically, given two spatial topologies, we can deduce which topology produces less infected individuals. In particular, we determine the topology that minimizes the overall number of infected individuals. It is worth noting that we do not assume any of the common simplifying assumptions in network theory such as all the links have the same diffusion rate or the movement of the individuals is symmetric. Our main conclusion is that the degree of mobility of the population plays a critical role in the spread of a disease. Finally, we derive theoretical insights to management of epidemics.

Critical role of Toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury

2006 ◽  
Vol 45 (6) ◽  
pp. 813-824 ◽  
Author(s):  
Arumugam Velayudham ◽  
Istvan Hritz ◽  
Angela Dolganiuc ◽  
Pranoti Mandrekar ◽  
Evelyn Kurt-Jones ◽  
...  
Keyword(s):  
Liver Injury ◽  
Critical Role ◽  
Toll Like Receptors ◽  
The Common

Success Factors for Public Access Computing

2011 ◽  
pp. 82-94
Author(s):  
Ricardo Gomez
Keyword(s):  
Success Factors ◽  
Critical Role ◽  
Common Factors ◽  
Public Access ◽  
Underserved Communities ◽  
The Common ◽  
Barriers To Use ◽  
Venue Staff

Throughout this book, we have detailed the profile of a public access venue user, discussed the role of venue staff in public access venues, identified the critical role that trust plays in use of public access venues, and demonstrated some barriers to use of venues, as well as explored how gender is situated in the ICT world. In this chapter, we will explore and seek to answer the question: what are the common factors that contribute to the success of public access ICT centers, especially in underserved communities?

scholarly journals Critical role for the common cytokine receptor gamma chain in intrathymic and peripheral T cell selection.

1996 ◽  
Vol 183 (3) ◽  
pp. 1111-1118 ◽  
Author(s):  
J P DiSanto ◽  
D Guy-Grand ◽  
A Fisher ◽  
A Tarakhovsky
Keyword(s):  
T Cells ◽  
T Cell ◽  
Critical Role ◽  
T Cell Development ◽  
Cell Selection ◽  
Gamma Chain ◽  
Peripheral T Cells ◽  
The Common ◽  
T Cell Selection

The common cytokine receptor gamma chain (gammac), which is a functional subunit of the receptors for interleukins (IL)-2, -4, -7, -9, and -15, plays an important role in lymphoid development. Inactivation of this molecule in mice leads to abnormal T cell lymphopoiesis characterized by thymic hypoplasia and reduced numbers of peripheral T cells. To determine whether T cell development in the absence of gammac is associated with alterations of intrathymic and peripheral T cell selection, we have analyzed gammac-deficient mice made transgenic for the male-specific T cell receptor (TCR) HY (HY/gammac- mice). In HY/gammac- male mice, negative selection of autoreactive thymocytes was not diminished; however, peripheral T cells expressing transgenic TCR-alpha and -beta chains (TCR-alphaT/betaT) were absent, and extrathymic T cell development was completely abrogated. In HY/gammac- female mice, the expression of the transgenic TCR partially reversed the profound thymic hypoplasia observed in nontransgenic gammac- mice, generating increased numbers of thymocytes in all subsets, particularly the TCR-alphaT/betaT CD8+ single-positive thymocytes. Despite efficient positive selection, however, naive CD8+ TCR-alphaT/betaT T cells were severely reduced in the peripheral lymphoid organs of HY/gammac- female mice. These results not only underscore the indispensible role of gammac in thymocyte development, but also demonstrate the critical role of gammac in the maintenance and/or expansion of peripheral T cell pools.

scholarly journals Impact and role of pulmonary embolism response teams in venous thromboembolism associated with COVID-19

2021 ◽  
pp. jim-2021-001856
Author(s):  
Mateo Porres-Aguilar ◽  
Victor F Tapson ◽  
Belinda N Rivera-Lebron ◽  
Parth M Rali ◽  
David Jiménez ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thromboembolism ◽  
Critical Role ◽  
Prothrombotic State ◽  
Common Goal ◽  
Optimal Patient Care ◽  
Response Team ◽  
The Common ◽  
Therapeutic Decision Making

Venous thromboembolism associated with COVID-19, particularly acute pulmonary embolism, may represent a challenging and complex clinical scenario. The benefits of having a multidisciplinary pulmonary embolism response team (PERT) can be important during such a pandemic. The aim of PERT in the care of such patients is to provide fast, appropriate, multidisciplinary, team-based approach, with the common goal to tailor the best therapeutic decision making, prioritizing always optimal patient care, especially given lack of evidence-based clinical practice guidelines in the setting of COVID-19, which potentially confers a significant prothrombotic state. Herein, we would like to briefly emphasize the importance and potential critical role of PERT in the care of patients in which these two devastating illnesses are present together.

scholarly journals 既「儒」且「醫」：論「儒醫」融合儒學與中國醫學的角色

2019 ◽  
Vol 33 (33) ◽  
pp. 061-108
Author(s):  
鄭中堅 鄭中堅
Keyword(s):  
Chinese Medicine ◽  
Critical Role ◽  
Modern Medicine ◽  
Moral Cultivation ◽  
Role Integration ◽  
Yin And Yang ◽  
Common Principle ◽  
The Common ◽  
Medicine Today

<p>「儒醫」同時擁有儒學與醫學的素養是具儒家特質的醫學群體，惟儒學是修身治國的學問，中國醫學則是養生治病的醫術，兩者屬性不同，「儒醫」如何加以融合？本文論證兼具「儒」與「醫」角色的「儒醫」如何在思想層面上融合儒學與中國醫學，首先析論「儒醫」的特質有助於融合儒學與中國醫學，再分別就角色綜合與思想會通的觀點加以論述，認為「儒醫」係透過「仁學」思想融合儒者與醫者的角色；並以「和」作為核心概念，聯結儒學的「中和思想」與中國醫學的「陰陽調和」思維，提出「儒醫」的醫學觀是儒學修養論與中國醫學調養論的相互交融。結論除總結各段，並從「儒醫」視角批判現代醫學發展「醫療商業化」（medical commercialization）與「過度醫療」（excessive medical treatment）的現象。</p> <p>&nbsp;</p><p>The Confucian physician at once embodies the common principle of self-cultivation shared by both the Confucian and medical communities. Both traditions are different; Confucianism being the only kind of political philosophy that emphasizes moral cultivation while Chinese medicine focuses on healing sickness, how may the Confucian physician integrate the two? </p> <p>This paper sets out to prove the critical role of the Confucian physician in philosophically integrating the two traditions.</p> <p>It will first analyze how the characteristics of the Confucian physician make the fusion of Confucianism and Chinese medicine possible, before distinguishing between the two processes of role integration as well as the synthesis of philosophical concepts and thus demonstrating that Confucian physicians call upon &ldquo;theories of benevolence&rdquo; to integrate Confucianism and medicine. With the concept of &ldquo;cohesive harmony&rdquo; at it&rsquo;s core, and by linking Confucianism&rsquo;s concept of &ldquo;Harmonization&rdquo; and Chinese medicine&rsquo;s &quot;Balancing of Yin and Yang&quot;, the Confucian physician&rsquo;s approach to medicine creates synergy between Confucianism&rsquo;s self-cultivation and Chinese Medicine&rsquo;s therapeutic nurturing.</p> <p>The summary will not only provide an overview of the argument, but will also apply the lens of the Confucian physician to critique the joint phenomena of commercialization and excessive treatment found in modern medicine today.</p> <p>&nbsp;</p>

scholarly journals An Integrated Effectiveness Framework of Mobile In-App Advertising

2019 ◽  
Vol 23 ◽  
Author(s):  
Vinh Nguyen Xuan Truong ◽  
Mathews Nkhoma ◽  
Wanniwat Pansuwong
Keyword(s):  
Mobile Apps ◽  
Critical Role ◽  
Advertising Revenue ◽  
The Common

Advertising in mobile apps has recently become one of the most popular advertising channels for businesses when its annual revenue has rapidly increased year over year. On this kind of advertising, the app publishers do not only play a critical role in the ad serving process but also receive a significant portion of the advertising revenue. Their goal of maximizing the revenue sometimes contradict with those of the advertisers. This research conceptualises the role of publishers and proposes an integrated effectiveness framework to further improve the effectiveness of mobile in-app advertising not for one but all participants involved. In specific, this research explores the factors being controlled by publishers and evaluates their impact on the common outcome metric of mobile in-app advertising. An application of the proposed effectiveness framework might help to increase the global mobile in-app advertising revenue significantly higher by balancing the benefits of all participants.

scholarly journals The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88

Hepatology ◽  
2008 ◽  
Vol 48 (4) ◽  
pp. 1224-1231 ◽  
Author(s):  
Istvan Hritz ◽  
Pranoti Mandrekar ◽  
Arumugam Velayudham ◽  
Donna Catalano ◽  
Angela Dolganiuc ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Critical Role ◽  
Toll Like Receptor ◽  
The Common

scholarly journals Critical role of IL-23 signaling in prostatic cancer

2013 ◽  
Vol 1 (1) ◽  
pp. 4-6 ◽  
Author(s):  
Salam Alhasani ◽  
Nasser Yousif ◽  
◽  
Keyword(s):  
Critical Role ◽  
Chronic Inflammatory Disease ◽  
Th1 Cell ◽  
Ifn Γ ◽  
The Common ◽  
Immune Pathways ◽  
Covalently Linked ◽  
Interleukin 23 ◽  
Stimulation Of

Interleukin 23 (IL-23) belongs to interleukin 6 super-family [1]. IL-12/23 p40 is the common subunit for them, which is covalently linked to either a p19 subunit to form IL-23 or a p35 subunit to form IL-12 [2]. Both cytokines are mainly expressed by activating dendrite cells or macrophages under the stimulation of pathogens. IL-23 was also reported to be secreted by tumor associated macrophages in tumor microenvironment [3]. Interestingly, IL-23 spur different immune pathways [4]. IL-12 induces IFN-γ-producing Th1 cell development and enhances cytotoxic, anti-microbial and anti-tumor responses; whereas IL-23 expands Th17 cells, which is mainly involved in the pathology of autoimmunity and chronic inflammatory disease [5].

scholarly journals The Medieval Blood Sanction and the Divine Beneficence of Pain: 1100-1450

2006 ◽  
Vol 22 (1) ◽  
pp. 63-129 ◽  
Author(s):  
Trisha Olson
Keyword(s):  
Middle Ages ◽  
Capital Punishment ◽  
Western Europe ◽  
Critical Role ◽  
Chest Cavity ◽  
Late Middle Ages ◽  
Wide Range ◽  
High Middle Ages ◽  
The Common

Here the worldling now all bound in fetters liesstarts to fear his God, his tears flow from his eyesJustice comes along, with gallows, wheel and sword:God tells the pious man to enter Heaven's door.Across medieval Western Europe, those who committed serious wrongs, such as homicide, arson, treason, and rape were subject to a wide range of capital punishments that were seemingly brutal, frequently bloody, and at times spectacular. Grisly images of an executioner dismembering a condemned's limbs from his torso, smashing his chest cavity, gouging his eyes, or piercing his body with hot pokers are the common stuff of scaffold art in the high Middle Ages. Such images attest to the critical role of pain in medieval capital punishment. Whereas in our day all attempts are made to render penal death painless, in the high and late Middle Ages, the tie between pain and death is not only tolerated but, at times, purposefully exacerbated.

The Role of the SLP in Autism Spectrum Disorder Screening and Assessment

2008 ◽  
Vol 15 (2) ◽  
pp. 50-59 ◽  
Author(s):  
Amy Philofsky
Keyword(s):  
Language Development ◽  
Critical Role ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Children With Asd ◽  
Prevalence Estimates ◽  
Notable Increase ◽  
Screening Assessment ◽  
Critical Components

AbstractRecent prevalence estimates for autism have been alarming as a function of the notable increase. Speech-language pathologists play a critical role in screening, assessment and intervention for children with autism. This article reviews signs that may be indicative of autism at different stages of language development, and discusses the importance of several psychometric properties—sensitivity and specificity—in utilizing screening measures for children with autism. Critical components of assessment for children with autism are reviewed. This article concludes with examples of intervention targets for children with ASD at various levels of language development.

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