UV-Visible spectroscopic and DFT studies of the binding of ciprofloxacin hydrochloride antibiotic drug with metal ions at numerous temperatures

Author(s):  
Mohammed Ashraf Uddin ◽  
Bupasha Hekim Sutonu ◽  
Malik Abdul Rub ◽  
Shamim Mahbub ◽  
Maha Moteb Alotaibi ◽  
...  
Drug Research ◽  
2021 ◽  
Author(s):  
Anuroop Kumar ◽  
Netrapal Singh ◽  
Mordhwaj Kumar ◽  
Uma Agarwal

AbstractThis article reports an amide based Chemosensor used for selective detection of divalent Cu+2 and Ni+2 ions via Fluorescence turn off. The selective sensing ability of Chemosensor was investigated in presence of different metal ions Mg2+, Ag+, Fe2+, K+, Cu2+, Ni2+, Hg2+, Pb2+, Mn2+, Pd2+, Cd2+ and Mn3+ as competitive ions. The receptor i. e. Chemosensor formed complexes with metal ions in 1:1 stoichiometric ratio. The detection limit and binding constant calculated as 1.92×10–4 and 1.4×10–4 M and 2.16×103 M−1 and 3.09×103 M−1 for Cu2+ and Ni2+ions respectively. The complexes were characterized by UV/visible, FT-IR, 13C NMR and 1H NMR spectroscopy. Further the structure and Crystallinity were calculated by P-XRD spectral analysis. The crystallinity found to be 65.27 and 67.87% respectively


Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1737 ◽  
Author(s):  
Marisela Martinez-Quiroz ◽  
Xiomara E. Aguilar-Martinez ◽  
Mercedes T. Oropeza-Guzman ◽  
Ricardo Valdez ◽  
Eduardo A. Lopez-Maldonado

This paper presents the synthesis and evaluation of physicochemical behavior of a new series of N-alkyl-bis-o-aminobenzamides (BOABs) in aqueous solution. The study was targeted to the complexing capacity of five metal ions (Fe2+, Cu2+, Cd2+, Hg2+ and Pb2+) of environmental concern as the medullar principle of a liquid phase sensor for its application in the determination of these metal ions due to its versatility of use. Molecular fluorescence, UV-visible and Zeta potential were measured for five BOABs and the effect of alkyl groups with different central chain length (n = 3, 4, 6, 8 and 10) on physicochemical performance determined. The results have shown that these derivatives present higher sensibility and selectivity for Cu2+ even in the presence of the other metal ions. An additional application test was done adding a pectin (0.1 wt %) solution to the BOAB-Cu+2 complex to obtain a precipitate (flocs) as a potential selective separation process of Cu from aqueous solution. The solid was then lyophilized and analyzed by SEM-EDS, the images showed spheric forms containing Cu+2 with diameter of approximately of 8 μm and 30 wt %.


2012 ◽  
Author(s):  
Rusmidah Ali ◽  
Siti Salamah Maisoan @ Selamat

Asid amino merupakan bahan asas dalam tisu tumbuhan dan haiwan. Tirosina (Tr) salah satu jenis asid amino yang mengandungi gelang aromatik, telah dipilih sebagai sampel untuk proses degradasi dalam medium akueus. Ini bertujuan melihat kesan penggunaan mangkinfoto dalam sinaran ultralembayung (λ < 400 nm) atau cahaya matahari ke atas molekul tirosina. Kajian telah dijalankan menggunakan sistem cahaya, mangkin serbuk TiO2, hidrogen peroksida, H2O2 dan ion logam. Penambahan ion logam seperti Ni2+, Cu2+, Ag+, Mn2+, Co2+, Fe2+ dan Cd2+ dan agen pengoksidaan, iaitu hidrogen peroksida adalah untuk mendapatkan kaedah yang paling cekap. Keputusan menunjukkan penambahan H2O2 dan ion Fe2+ dan Ni2+ berjaya meningkatkan kecekapan proses degradasifoto tirosina. Ion Ni2+ memberikan keputusan terbaik berbanding ion-ion lain. Ion Cu2+, Ag+, Mn2+ dan Cd2+ merencat proses degradasi. Keputusan juga menunjukkan cahaya matahari adalah setanding dengan cahaya ultralembayung. Kepekatan H2O2 terbaik adalah 5.0 x 10-2M dan semakin banyak TiO2 digunakan semakin baik peratus degradasi tirosina. Oleh itu kaedah optimum untuk proses degradasifoto ialah Tr 2.5 x 10-4 M + TiO2 + H2O25.0 x 10-3 M + Mn+ 1.0 x 10-2 M. Proses degradasifoto dikaji menggunakan spektroskopi ultralembayung-nampak pada julat panjang gelombang 400-200 nm. Kata kunci: Tirosina; degradasifoto; serbuk TiO; akueus Amino acid is a basic component in plant or animal tissue. Tyrosine (Tr), an amino acid which contains aromatic ring, was chosen as a sample for a photodegradation process in an aqueous system. The purpose of the experiment is to study the effect of photocatalysis under UV (λ < 400 nm) or sunlight on tyrosine. The experiment was carried out by using UV light, catalyst powder (TiO2), hidrogen peroxide H2O2 and metal ions system. The addition of oxidising agent H2O2 and metal ions such as Ni2+, Cu2+, Ag+, Mn2+, Co2+, Fe2+ and Cd2+ were used in order to achieve the most efficient system. Results showed that the system with added H2O2 and metal ions such as Ni2+ and Fe2+ had successfully enhanced the process of the tyrosine photodegradation. Other metal ions system such as Cu2+, Ag+, Mn2+ and Cd2+ were found to inhibit the degradation process. The results also showed that sunlight was comparable to ultraviolet light. The best H2O2 concentration was 5.0 x 10-2 M and the percentage of tyrosine degradation increased with the addition of more TiO2) by mass. Therefore, the optimum condition for tyrosine photodegradation process was in Tr 2.5 x 10-4 M + TiO2 + H2O2 5.0 x 10-3 M + H2O2 1.0 x 10-2 M. The dissappearance of tyrosine in the photo degradation process was monitored by UV-visible spectroscopy between 400-200 nm. Key words: Tyrosine; photodegradation; TiO2 powder; akueus


Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3941 ◽  
Author(s):  
Ozsváth ◽  
Bíró ◽  
Nagy ◽  
Buglyó ◽  
Sanna ◽  
...  

By using various techniques (pH-potentiometry, UV-Visible spectrophotometry, 1H and 17O-NMR, EPR, ESI-MS), first time in the literature, solution equilibrium study has been performed on complexes of dipeptide and tripeptide hydroxamic acids—AlaAlaNHOH, AlaAlaN(Me)OH, AlaGlyGlyNHOH, and AlaGlyGlyN(Me)OH—with 4d metals: the essential Mo(VI) and two half-sandwich type cations, [(η6-p-cym)Ru(H2O)3]2+ as well as [(η5-Cp*)Rh(H2O)3]2+, the latter two having potential importance in cancer therapy. The tripeptide derivatives have also been studied with some biologically important 3d metals, such as Fe(III), Ni(II), Cu(II), and Zn(II), in order to compare these new results with the corresponding previously obtained ones on dipeptide hydroxamic acids. Based on the outcomes, the effects of the type of metal ions, the coordination number, the number and types of donor atoms, and their relative positions to each other on the complexation have been evaluated in the present work. We hope that these collected results might be used when a new peptide-based hydroxamic acid molecule is planned with some purpose, e.g. to develop a potential metalloenzyme inhibitor.


2010 ◽  
Vol 7 (4) ◽  
pp. 1598-1604 ◽  
Author(s):  
Shayma A. Shaker

This paper presents a new mixed-ligand complexes with the general formula [M(BT)(BI)2X2] where BT=benzotriazole, BI=benzimidazole, X=SCN and M=Mn(II), Co(II), Ni(II), Cu(II), Cd(II) and Pb(II). The reaction was carried out by using the appropriate molar ratios of metal:ligand (1:1:2:2) (M:BT:BI:X) as required. The resulting products were found to be solids, not soluble in water and in ordinary organic solvents but highly soluble in DMSO. These complexes have been studied by UV-visible, IR and (1H,13C) NMR spectra, molar conductivity, elemental analysis of C, H, N, determination of metal and magnetic susceptibility. The result suggests that the benzimidazoleas as a monodentate was coordinated with the metal ions through the N atom. Nevertheless, the benzotriazole as bidentate was coordinated with the metal ions through the N2 and N3 atoms. SCN was coordinated with the metal ions through the nitogen atom.


1990 ◽  
Vol 68 (5) ◽  
pp. 774-781 ◽  
Author(s):  
Mohamed S. Abdel-Moez ◽  
Shaker L. Stefan ◽  
Mostafa M. El-Behairy ◽  
Mohamed M. Mashely ◽  
Basheir A. El-Shetary

The stepwise stability constants of VO(II), Mn(II), Cu(II), Ni (II), Co(II), Zn(II), Fe(III), and UO2(II) metal ions with 2-(2-acetylphenylhydrazone)-5,5-dimethyl-1,3-cyclohexane dione (2-APHDm), 3-(2-acetylphenylhydrazone)pentane-2,4-dione (2-APHA), 2-(2-acetylphenylhydrazone)-1-phenyl-1,3-butane dione (2-APHB), 2-(2-acetylphenylhydrazone)-1,3-diphenyl-1,3-propane dione (2-APHDB), and 3-(2-acetylphenylhydrazone)-1,1,1-trifluoropentane-2,4-dione (2-APHTA) were determined at 30 °C by pH titrations in 75% (v/v) dioxane–water solvent. In addition, metal complexes of three related β-diketones, 2-APHA, 2-APHB, and 2-APHDB have been synthesized and characterized by elemental analysis, uv–visible, ir spectra, and conductance in DMF and magnetic susceptibility measurements. The structure of the complexes have been proposed. Keywords: transition metal complexes of hydrazone-β-diketone ligands.


2015 ◽  
Author(s):  
◽  
Nirvashini Bipath

In this study, we report the synthesis of three quinolone bearing imidazole derivatives 2, 3 and 4 and two quinolone bearing BODIPY dyes 5 and 7. In the synthesis of 2, 3 and 4, the first step was the preparation of the starting compound 2-chloro-3-formyl quinoline (1); the Vilsmeier-Haack cyclisation protocol was used. Compound 1 was used with the appropriate diamine, together with POCl3 to produce 2, 3 and 4. These compounds were characterized by IR, 1H-NMR and 13C-NMR. In the synthesis of 5, compound 1 was used whilst 6 was used for the synthesis of 7. This was via. a one-pot synthesis using conventional reflux apparatus and Schlenk technique. These compounds were characterized by IR, 1H-NMR and 13C-NMR. Four other BODIPY dyes were also synthesized but their purification by column chromatography were unsuccessful. However a HPLC method was developed using 2 as a model; the best eluting solvent was 65 % methanol. After synthesis, 2, 3, 4, 5 and 7 were used for spectroscopic studies by UV-visible and fluorescence spectroscopy. In the UV-visible studies, 2, 3 and 4 were dissolved, separately, in five solvent viz. ethanol, methanol, dichloromethane, chloroform and acetonitrile. The UV profile of each compound was obtained and the maximum absorbance was then used for fluorescence studies. In the fluorescence studies, all the compounds displayed a fluorescence nature when excited with the various wavelengths. The fluorescence properties, namely Stoke shift, quantum yield, life time, molar absorptivity and brightness, were investigated to establish the properties of each compound in all five solvent systems. The Stoke shift was evident in all compounds and the quantum yields were below one which indicates no other electron transfer mechanisms occurring. The results displayed a favorable response and this further lead to analysis of the synthesized compounds for it potential application as a chemosensor. Eight metal ions were used to investigate this property. All eight metal ions, when reacted with the synthesized compounds, as ligands, showed chemosensor properties, viz. photon induced electron transfer, inter-molecular charge transfer and fluorescence resonance electron transfer, as a quenching and enhancement of emission and excitation peaks were observed. The compounds were further investigated for its potential for its use as a photovoltaic cells. The energies of the compounds were obtained from the analyses of the reflectance and transmission spectra. It was found that the synthesized compounds displayed properties which were positive for its use as a photovoltaic cell. Biological analyses using molecular docking analyses and MTT assays were conducted to determine the use of these as an anti-cancer drug. Compounds 2 and 3 formed hydrogen bonds with GLU 25 and LEU 27, respectively with MDM2-p53 proteins. Following the molecular docking studies, the MTT assay was performed on all five synthesized compounds. The BODIPYs with the quinoline moieties demonstrated a reduction in the rate of A549 cell proliferation when compared to the imidazole and benzimidazoles; this was observed for compounds 5 and 7. Further, a comparison between imidazoles clearly shows that compounds 3 and 4 also decreased cell proliferation. In contrast compound 2 exhibited an increased rate of cell proliferation. The optical density of the control cell, is much higher that the plates for concentration 31.25 µg/ mL to 500 µg/ mL. However 2 cannot be discarded; this compound clearly shows that it possesses anti-hyperglycaemic properties and further studies are recommended.


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