The effect of 8 weeks of combined interval (resistance-interval training) and combined endurance (endurance-resistance training) on plasma levels of adropin and nitric oxide in males with high blood pressure

Author(s):  
Maryam Salmanpour ◽  
Rahman Soori ◽  
Cyrine H’mida ◽  
Jamel Halouani ◽  
Cain T. Clarck ◽  
...  
2009 ◽  
Vol 296 (2) ◽  
pp. R195-R200 ◽  
Author(s):  
Dan Wang ◽  
Svend Strandgaard ◽  
Jens Iversen ◽  
Christopher S. Wilcox

We reported impaired endothelium-derived relaxation factor/nitric oxide (EDRF/NO) responses and constitutive nitric oxide synthase (cNOS) activity in subcutaneous vessels dissected from patients with essential hypertension ( n = 9) compared with normal controls ( n = 10). We now test the hypothesis that the patients in this study have increased circulating levels of the cNOS inhibitor, asymmetric dimethylarginine (ADMA), or the lipid peroxidation product of linoleic acid, 13-hydroxyoctadecadienoic acid (HODE), which is a marker of reactive oxygen species. Patients had significantly ( P < 0.001) elevated (means ± SD) plasma levels of ADMA (PADMA, 766 ± 217 vs. 393 ± 57 nmol/l) and symmetric dimethylarginine (PSDMA: 644 ± 140 vs. 399 ± 70 nmol/l) but similar levels of l-arginine accompanied by significantly ( P < 0.015) increased rates of renal ADMA excretion (21 ± 9 vs. 14 ± 5 nmol/μmol creatinine) and decreased rates of renal ADMA clearance (18 ± 3 vs. 28 ± 5 ml/min). They had significantly increased plasma levels of HODE (PHODE: 309 ± 30 vs. 226 ± 24 nmol/l) and renal HODE excretion (433 ± 93 vs. 299 ± 67 nmol/μmol creatinine). For the combined group of normal and hypertensive subjects, the individual values for plasma levels of ADMA and HODE were both significantly ( P < 0.001) and inversely correlated with microvascular EDRF/NO and positively correlated with mean blood pressure. In conclusion, elevated levels of ADMA and oxidative stress in a group of hypertensive patients could contribute to the associated microvascular endothelial dysfunction and elevated blood pressure.


2004 ◽  
Vol 22 (Suppl. 1) ◽  
pp. S152
Author(s):  
Tomas Janota ◽  
P. Jakubik ◽  
J. Hradec ◽  
H. Benakova ◽  
D. Wichterle ◽  
...  

2018 ◽  
Vol Volume 14 ◽  
pp. 213-223 ◽  
Author(s):  
Gulfiia Nagimovna Aflyatumova ◽  
Razina Nigmatullina ◽  
Dinara Ilgizarovna Sadykova ◽  
Mariia Dmitrievna Chibireva ◽  
Francesco Fugetto ◽  
...  

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Carmine Vecchione ◽  
Francesco Villa ◽  
Albino Carrizzo ◽  
Chiara Carmela Spinelli ◽  
Antonio Damato ◽  
...  

1996 ◽  
Vol 175 (2) ◽  
pp. 484-488 ◽  
Author(s):  
Darrell L. Edwards ◽  
Chander P. Arora ◽  
Dung T. Bui ◽  
Lony C. Castro

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Carmine Vecchione ◽  
Francesco Villa ◽  
Albino Carrizzo ◽  
Chiara Carmela Spinelli ◽  
Antonio Damato ◽  
...  

Salmand ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. 16-27
Author(s):  
Alireza Behjati Ardakani ◽  
Ahmad Qassemian ◽  
Maryam Koushki ◽  
Elham Shakour ◽  
Ahmad Mehrez ◽  
...  

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