The Possible Protective Effect of Boric Acid in an Alkaline-Induced Corneal Neovascularization Rat Model

2022 ◽  
Author(s):  
Umut Karaca ◽  
Sıla Gulbag Pinar ◽  
Mehtap Savran ◽  
Gulsah Usta ◽  
İlter İlhan ◽  
...  
Keyword(s):  
Protective Effect ◽  
Boric Acid ◽  
Rat Model ◽  
Corneal Neovascularization

Protective Effect of Boric Acid and Omega-3 on Myocardial Infarction in an Experimental Rat Model

2020 ◽  
Author(s):  
Hadi Karimkhani ◽  
Mete Özkoç ◽  
Paria Shojaolsadati ◽  
Kubilay Uzuner ◽  
Dilek Burukoglu Donmez ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Protective Effect ◽  
Boric Acid ◽  
Rat Model ◽  
Omega 3 ◽  
Experimental Rat Model

Protective Effect of Swertiamarin on Myocardial Injury Through Activation of Nrf2/HO-1 Pathway in Heart Failure Model of Rats

2020 ◽  
Vol 18 (3) ◽  
pp. 260-265
Author(s):  
Xu Lin ◽  
Zheng Xiaojun ◽  
Lv Heng ◽  
Mo Yipeng ◽  
Tong Hong
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Ejection Fraction ◽  
Protective Effect ◽  
Infarct Size ◽  
Rat Model ◽  
Left Ventricular ◽  
Related Factor ◽  
Nuclear Factor ◽  
Internal Dimension

The purpose of this study was to evaluate the protective effect of swertiamarin on heart failure. To this end, a rat model of heart failure was established via left coronary artery ligation. Infarct size of heart tissues was determined using triphenyl tetrazolium chloride staining. Echocardiography was performed to evaluate cardiac function by the determination of ejection fraction, left ventricular internal dimension in diastole and left ventricular internal dimension in systole. The effect of swertiamarin on oxidative stress was evaluated via enzyme-linked immunosorbent assay. The mechanism was evaluated using western blot. Administration of swertiamarin reduced the infarct size of heart tissues in rat models with heart failure. Moreover, swertiamarin treatment ameliorated the cardiac function, increased ejection fraction and fractional shortening, decreased left ventricular internal dimension in diastole and left ventricular internal dimension in systole. Swertiamarin improved oxidative stress with reduced malondialdehyde, while increased superoxide dismutase, glutathione, and GSH peroxidase. Furthermore, nuclear-factor erythroid 2-related factor 2, heme oxygenase and NAD(P)H dehydrogenase (quinone 1) were elevated by swertiamarin treatment in heart tissues of rat model with heart failure. Swertiamarin alleviated heart failure through suppression of oxidative stress response via nuclear-factor erythroid 2-related factor 2/heme oxygenase-1 pathway providing a novel therapeutic strategy for heart failure.

scholarly journals Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 647
Author(s):  
Henry T. Hsueh ◽  
Yoo-Chun Kim ◽  
Ian Pitha ◽  
Matthew D. Shin ◽  
Cynthia A. Berlinicke ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Rat Model ◽  
Kinase Inhibitor ◽  
Ganglion Cells ◽  
Corneal Neovascularization ◽  
Therapeutic Effects ◽  
Subconjunctival Injection ◽  
Retinal Ganglion ◽  
Drug Concentrations ◽  
Complementary Strategy

Glaucoma is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is one of the major risk factors for glaucoma onset and progression, and available pharmaceutical interventions are exclusively targeted at IOP lowering. However, degeneration of retinal ganglion cells (RGCs) may continue to progress despite extensive lowering of IOP. A complementary strategy to IOP reduction is the use of neuroprotective agents that interrupt the process of cell death by mechanisms independent of IOP. Here, we describe an ion complexation approach for formulating microcrystals containing ~50% loading of a protein kinase inhibitor, sunitinib, to enhance survival of RGCs with subconjunctival injection. A single subconjunctival injection of sunitinib-pamoate complex (SPC) microcrystals provided 20 weeks of sustained retina drug levels, leading to neuroprotection in a rat model of optic nerve injury. Furthermore, subconjunctival injection of SPC microcrystals also led to therapeutic effects in a rat model of corneal neovascularization. Importantly, therapeutically relevant retina drug concentrations were achieved with subconjunctival injection of SPC microcrystals in pigs. For a chronic disease such as glaucoma, a formulation that provides sustained therapeutic effects to complement IOP lowering therapies could provide improved disease management and promote patient quality of life.

scholarly journals Metabolomics reveal the protective effect of Farfarae Flos against asthma using an OVA-induced rat model

RSC Advances ◽  
2017 ◽  
Vol 7 (63) ◽  
pp. 39929-39939 ◽  
Author(s):  
Jing Li ◽  
Wei Gao ◽  
Jining Gao ◽  
Hong Li ◽  
Xiang Zhang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Rat Model ◽  
Biochemical Assay ◽  
H Nmr

A 1H NMR based metabolomics approach combined with biochemical assay and histopathological inspection has been employed to study the protective effect of PEFF against asthma on a rat model.

scholarly journals Protective effect of grifolin against brain injury in an acute cerebral ischemia rat model

2017 ◽  
Vol 16 (6) ◽  
pp. 1299 ◽  
Author(s):  
Shan Jing ◽  
Piaopiao Ying ◽  
Xiaohua Hu ◽  
Ze Yu ◽  
Jianwei Sun ◽  
...  
Keyword(s):  
Brain Injury ◽  
Cerebral Ischemia ◽  
Protective Effect ◽  
Rat Model ◽  
Acute Cerebral Ischemia

scholarly journals The Protective Effect of Celecoxib on CA1 Hippocampal Neurons and Oxidative Stress in a Rat Model of Parkinson’s Disease

2019 ◽  
Author(s):  
Maryam Sarbishegi ◽  
Hamidreza Mahmoudzadeh-sagheb ◽  
Zahra Heidari ◽  
Farzaneh Baharvand
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Protective Effect ◽  
Passive Avoidance ◽  
Rat Model ◽  
Hippocampal Neurons ◽  
Wistar Rat ◽  
Tunel Staining ◽  
Model Animal ◽  
Avoidance Memory

Abstract- Several studies point to an important role of neuroinflammation in Parkinson's disease (PD). Cognitive and memory impairments have been known in the early stages of PD. In the present study, we examined the effects of celecoxib (CLX), a selective inhibitor of cyclooxygenase-2 (COX-2), on hippocampus cell loss, passive avoidance memory and antioxidant status in a rat model of PD. We used the subcutaneous injection of 2.5 mg/kg/48h rotenone (ROT) for 4 weeks for induction of PD in a male Wistar rat. Animals were randomized to 4 groups (n=12): Control, sham, PD and PD+CLX group that receive celecoxib (20 mg/kg/day) for 4 weeks. Passive avoidance memory evaluated. We also determined the protective effect of CLX on a number of CA1 neurons in Nissl and TUNEL staining. Total antioxidant capacity (TAC) and malondialdehyde (MDA) a marker of lipid peroxidation in hippocampus assessed. Our findings indicated administration of CLX increase the passive avoidance memory (P<0.05), and by a decrease in apoptosis caused an increase in viable pyramidal neurons in CA1 hippocampus (P<0.01). On the other hand, CLX markedly reduced MDA level and increased TAC in the hippocampus of the PD model animal (P<0.05). It seems CLX with anti-inflammatory and antiapoptotic effect could prevent neurons loss and memory impairment which induced in PD.

scholarly journals Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model

2021 ◽  
Vol 58 (4) ◽  
pp. 241-248
Author(s):  
Fatma Atalay ◽  
◽  
Arzu Tatar ◽  
Busra Dincer ◽  
Betul Gundogdu ◽  
...  
Keyword(s):  
Protective Effect ◽  
Rat Model
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