DNA Methylation-Dependent Gene Expression Regulation of Glutamate Transporters in Cultured Radial Glial Cells

Author(s):  
Ada G. Rodríguez-Campuzano ◽  
Luisa C. Hernández-Kelly ◽  
Arturo Ortega
Biochimie ◽  
2020 ◽  
Vol 173 ◽  
pp. 12-16 ◽  
Author(s):  
Andrea Fuso ◽  
Tiziana Raia ◽  
Michela Orticello ◽  
Marco Lucarelli

2019 ◽  
Vol 161 ◽  
pp. 107550 ◽  
Author(s):  
Tatiana N. Olivares-Bañuelos ◽  
Donají Chí-Castañeda ◽  
Arturo Ortega

Author(s):  
Elisabeth Pellegrini ◽  
Colette Vaillant ◽  
Nicolas Diotel ◽  
Pascal Benquet ◽  
François Brion ◽  
...  

2014 ◽  
Vol 20 (11) ◽  
pp. 1726-1750 ◽  
Author(s):  
Rosamaria Calicchio ◽  
Ludivine Doridot ◽  
Francisco Miralles ◽  
Celine Mehats ◽  
Daniel Vaiman

2017 ◽  
Vol 214 (3) ◽  
pp. 1213-1229 ◽  
Author(s):  
Gina M. Turco ◽  
Kaisa Kajala ◽  
Govindarajan Kunde-Ramamoorthy ◽  
Chew-Yee Ngan ◽  
Andrew Olson ◽  
...  

The Analyst ◽  
2022 ◽  
Author(s):  
Ji Yoon Lee ◽  
Joon Won Park

DNA methylation plays key roles in various areas, such as gene expression, regulation, epigenetics, and cancers. Since 5-methylcytosine (5mC) is commonly present in methylated DNA, characterizing the binding kinetics and...


2021 ◽  
Vol 12 (7) ◽  
Author(s):  
Kunzhao Du ◽  
Zhen Zhang ◽  
Zhiwei Zeng ◽  
Jinling Tang ◽  
Trevor Lee ◽  
...  

AbstractProper development of the mammalian cerebral cortex relies on precise gene expression regulation, which is controlled by genetic, epigenetic, and epitranscriptomic factors. Here we generate RNA demethylase Fto and methyltransferase Mettl3 cortical-specific conditional knockout mice, and detect severe brain defects caused by Mettl3 deletion but not Fto knockout. Transcriptomic profiles using RNA sequencing indicate that knockout of Mettl3 causes a more dramatic alteration on gene transcription than that of Fto. Interestingly, we conduct ribosome profiling sequencing, and find that knockout of Mettl3 leads to a more severe disruption of translational regulation of mRNAs than deletion of Fto and results in altered translation of crucial genes in cortical radial glial cells and intermediate progenitors. Moreover, Mettl3 deletion causes elevated translation of a significant number of mRNAs, in particular major components in m6A methylation. Our findings indicate distinct functions of Mettl3 and Fto in brain development, and uncover a profound role of Mettl3 in regulating translation of major mRNAs that control proper cortical development.


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