scholarly journals A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland

2021 ◽  
Author(s):  
Yun Zhu ◽  
Baoping Xu ◽  
Changchong Li ◽  
Zhimin Chen ◽  
Ling Cao ◽  
...  
2018 ◽  
Vol 5 (10) ◽  
Author(s):  
Kathleen Chiotos ◽  
Pranita D Tamma ◽  
Kelly B Flett ◽  
Manjiree V Karandikar ◽  
Koorosh Nemati ◽  
...  

Abstract In this multicenter study, we identified an increased risk of 30-day mortality among hospitalized children with carbapenem-resistant Enterobacteriaceae (CRE) isolated from clinical cultures compared with those with carbapenem-susceptible Enterobacteriaceae. We additionally report significant variation in antibiotic treatment for children with CRE infections with infrequent use of combination therapy.


2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S405-S406
Author(s):  
Alexandra B Yonts ◽  
Michael Jason Bozzella ◽  
Matthew Magyar ◽  
Laura O’Neill ◽  
Nada Harik

Abstract Background Community-acquired pneumonia (CAP) is the most common diagnosis in hospitalized children. The Pediatric Infectious Diseases Society and the Infectious Diseases Society of America published evidenced-based clinical practice guidelines for the management of CAP in children 3 months of age or older in 2011. These guidelines are not consistently followed. Our objective was to evaluate if quality improvement (QI) methods could improve guideline-concordant antibiotic prescribing, specifically addressing the use of oral third-generation cephalosporins, at hospital discharge for children with uncomplicated CAP. Methods QI interventions, implemented at a single tertiary care children’s hospital in Washington, D.C., focused on key drivers targeting hospital medicine resident teams. Multiple plan-do-study-act (PDSA) cycles were performed. Initial interventions included educational sessions (in small group and lecture formats) aimed at pediatric resident physicians, as well as visual job aids (Figure 1) and guideline summaries posted in resident physician work areas. Interventions were implemented in series to allow for statistical analysis via run chart. Medical records of eligible patients were reviewed monthly after each intervention to determine the impact on appropriate discharge antibiotic prescribing. Results At baseline, the median percentage of children with a diagnosis of uncomplicated CAP discharged with guideline-concordant antibiotics was 50%. Median rates of guideline-concordant antibiotic prescribing improved to 87.5% after initial interventions (Figure 2). Conclusion A fellow-led multidisciplinary QI initiative was successful in decreasing rates of non-guideline-concordant antibiotic prescribing at discharge. These interventions can be tailored for use at other institutions and for other infectious processes with established treatment guidelines. To ensure sustained improvement in guideline-concordant prescribing, future planned interventions include additional educational sessions with residents, faculty, and pharmacists, EMR order set modification and physician benchmarking. These tactics are intended to address the anticipated challenge of resident/faculty turnover and automate antibiotic choice for uncomplicated CAP. Disclosures All authors: No reported disclosures.


2002 ◽  
Vol 24 (5) ◽  
pp. 736-751 ◽  
Author(s):  
Mark H. Gotfried ◽  
Dan Dattani ◽  
Ernie Riffer ◽  
Karen J. Devcich ◽  
Todd A. Busman ◽  
...  

Author(s):  
Julie Poline ◽  
Jean Gaschignard ◽  
Claire Leblanc ◽  
Fouad Madhi ◽  
Elsa Foucaud ◽  
...  

Abstract To assess the relevance of systematic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) screening of all children admitted to hospital, we conducted a prospective multicenter study including 438 consecutive hospitalized children. A symptom-based SARS-CoV-2 testing strategy failed to identify 45% (95% confidence interval, 24%–68%) of hospitalized children infected by SARS-CoV-2. To limit intrahospital transmission, a systematic screening of children admitted to hospital should be considered.


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