scholarly journals Checkpoint inhibitor pneumonitis: Short review of literature and case report

2021 ◽  
Author(s):  
Romana Elisabeth Wass ◽  
David Lang ◽  
Andreas Horner ◽  
Bernd Lamprecht
Keyword(s):  
Case Report ◽  
Checkpoint Inhibitor ◽  
Short Review ◽  
Immune Checkpoint Blockade ◽  
Advanced Lung Cancer ◽  
Review Of Literature ◽  
Multiple Organs ◽  
Duration Of Response ◽  
Life Threatening

SummaryImmune checkpoint blockade (ICB) has fundamentally improved the treatment landscape of advanced lung cancer. Improved tolerability and encouraging duration of response in selected patients are some of the advantages of ICB over conventional cytotoxic chemotherapies. However, immune-related adverse events (irAEs) possibly affecting multiple organs pose challenges in diagnosis and management. Checkpoint inhibitor pneumonitis (CIP) is a rare but clinically highly relevant irAE that can significantly impair quality of life and can be potentially life threatening. Since its heterogeneity in clinical and radiographic presentation, diagnosis can be challenging. Treatment usually consists of discontinuing or delaying the administration of ICB. If there is no sufficient recovery with this measure, steroid therapy is indicated. Although the majority of cases improves with this therapy, steroid-refractory CIP can be a therapeutic challenge as there is currently no evidence-based standard treatment. We herein present a short review of literature and a case report of relapsing CIP under steroid treatment.

Polyarteritis Nodosa Following Vaccination Against Hepatitis B Virus with Lower-Extremity Manifestations: A Case Report

2019 ◽  
Vol 109 (3) ◽  
pp. 241-245
Author(s):  
Daniel R. Wright ◽  
Jenni M. Davis ◽  
Karl Robstad ◽  
Melissa D. Shah ◽  
Michael C. Keller ◽  
...  
Keyword(s):  
Case Report ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Polyarteritis Nodosa ◽  
Peripheral Nerves ◽  
Hepatitis B Virus Infection ◽  
Multiple Organs ◽  
B Virus ◽  
Life Threatening

Polyarteritis nodosa is a progressive, often life-threatening, vasculitis affecting multiple organs, including the skin and peripheral nerves. We report a patient presenting with systemic features of the disease and with characteristic lesions in the feet 3 weeks after vaccination against hepatitis B virus infection.

scholarly journals Hemorrhagic Pseudocyst of Pancreas Treated with Coil Embolization of Gastroduodenal Artery: A Case Report and Review of Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Sudhir Kumar Jain ◽  
Vishnuraja Rajendran ◽  
Maneesh K. Jain ◽  
Ronal Kori
Keyword(s):  
Acute Pancreatitis ◽  
Case Report ◽  
Ct Angiography ◽  
Coil Embolization ◽  
Gastroduodenal Artery ◽  
Gi Bleeding ◽  
Review Of Literature ◽  
Upper Gi Bleeding ◽  
Upper Gi ◽  
Life Threatening

Hemorrhage into pseudocyst of pancreas can rarely present as life threatening massive UGI bleeding. We present a case of 21-year-old male, admitted to our department, who was a known case of posttraumatic acute pancreatitis and who developed massive upper GI bleeding. CT angiography of abdomen showed aneurysm of gastroduodenal artery. Patient was successfully treated with coil embolization of gastroduodenal artery.

Antipsychotics-induced leukopenia and neutropenia: A case report and review of literature

2016 ◽  
Vol 33 (S1) ◽  
pp. S546-S546 ◽  
Author(s):  
H. Maatallah ◽  
H. Ben Ammar ◽  
M. Said ◽  
A. Aissa
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Atypical Antipsychotics ◽  
Antipsychotic Drugs ◽  
Psychotic Symptoms ◽  
Review Of Literature ◽  
Blood Cell Count ◽  
Life Threatening ◽  
Dsm Iv ◽  
Competing Interest

IntroductionAntipsychotic drugs effectively control psychotic symptoms, but may cause important side effects, significantly increasing morbidity and mortality. Hematologic abnormalities are frequent and may be life-threatening in some patients. Many prospective investigations confirmed neutropenia as a frequent occurrence with virtually all atypical antipsychotics.Objective and methodsDefine epidemiological, clinical and therapeutic characteristics of antipsychotics – induced leukopenia and neutropenia through a case report and a review of literature.Case reportPatient 28 years old native of Tunis, with family history: brother who suffer of undifferentiated schizophrenia. Since the age of 16 years he has been followed for disorganized schizophrenia (DSM IV). He was initially put under Haldol Decanoate (2 months), fluphenazine (2 months), amisulpride (3 months), sulpride (2 months), olanzapine (3 months), Rispreridone (1 month), aripiprazole (5 months) leukopenia/neutropenia is occurring during treatment with each molecule and which promptly resolved after discontinuation. Reduced white blood cell count has also been reported after addition of lithium. Actually an ECT is proposed for this patient.ConclusionThis case report shows the importance of hematological monitoring during the course of typical or atypical treatment.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Electrical Storms after Levonorgestrel (Synthetic Progestin)-Releasing Intra-Vaginal Device Insertion. A Case Report and a Short Review of Literature

2018 ◽  
Vol 08 (04) ◽  
pp. 338-343
Author(s):  
Sergio Fasullo ◽  
Giorgio Maringhini ◽  
Piero Fasullo ◽  
Filippo Ganci ◽  
Arcangelo Giamporcaro ◽  
...  
Keyword(s):  
Case Report ◽  
Short Review ◽  
Review Of Literature ◽  
Vaginal Device
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