Fixed-dose Combination of Metoprolol, Telmisartan, and Chlorthalidone for Essential Hypertension in Adults with Stable Coronary Artery Disease: Phase III Study

Author(s):  
Gouranga Sarkar ◽  
Vijay B. Gaikwad ◽  
Aradhana Sharma ◽  
Swapan K. Halder ◽  
Darivemula A. Kumar ◽  
...  
2021 ◽  
Vol 26 (9) ◽  
pp. 4657
Author(s):  
A. M. Shimkevich

This article discusses a case of using fixed-dose combination of ivabradine/metoprolol in actual clinical practice.


1994 ◽  
Vol 74 (7) ◽  
pp. 657-661 ◽  
Author(s):  
Shaun G. Goodman ◽  
Anatoly Langer ◽  
Sherri S. Durica ◽  
Gary E. Raskob ◽  
Philip C. Comp ◽  
...  

2020 ◽  
Author(s):  
Krithika Loganath ◽  
Philip D Adamson ◽  
Alastair J Moss

Ticagrelor is a potent and orally active P2Y12 inhibitor. Ticagrelor has been extensively tested in Phase II and Phase III trials in patients with coronary artery disease. The pharmacokinetics and pharmacodynamics of Ticagrelor result in more rapid and effective inhibition of platelet activation compared with other P2Y12 inhibitors. This has resulted in a reduction in recurrent major cardiovascular events in initial randomized controls trials comparing Ticagrelor with clopidogrel. More recently, clinical trials have investigated the use of Ticagrelor in patients with stable coronary artery disease and a high residual risk of coronary thrombotic events. In patients with stable coronary artery disease, the potent antiplatelet effect of Ticagrelor is counterbalanced by an increased risk of major bleeding. Further research is ongoing to determine the optimal duration of Ticagrelor therapy.


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