A Pilot Study on the Comparison of the Methods for Uncertainty Analysis of Micropipette Calibration

MAPAN ◽  
2021 ◽  
Author(s):  
Santwana Pati ◽  
Goutam Mandal ◽  
Nidhi Singh ◽  
Manoj Kumar ◽  
D. C. Sharma
Author(s):  
Leonid Gutkin ◽  
Suresh Datla ◽  
Christopher Manu

Canadian Nuclear Standard CSA N285.8, “Technical requirements for in-service evaluation of zirconium alloy pressure tubes in CANDU® reactors”(1), permits the use of probabilistic methods when assessments of the reactor core are performed. A non-mandatory annex has been proposed for inclusion in the CSA Standard N285.8 to provide guidelines for performing uncertainty analysis in probabilistic fitness-for-service evaluations within the scope of this Standard, such as the probabilistic evaluation of leak-before-break. The proposed annex outlines the general approach to uncertainty analysis as being comprised of the following major activities: identification of influential variables, characterization of uncertainties in influential variables, and subsequent propagation of these uncertainties through the evaluation framework or code. The proposed methodology distinguishes between two types of non-deterministic variables by the method used to obtain their best estimate. Uncertainties are classified by their source, and different uncertainty components are considered when the best estimates for the variables of interest are obtained using calibrated parametric models or analyses and when these estimates are obtained using statistical models or analyses. The application of the proposed guidelines for uncertainty analysis was exercised by performing a pilot study for one of the evaluations within the scope of the CSA Standard N285.8, the probabilistic evaluation of leak-before-break based on a postulated through-wall crack. The pilot study was performed for a representative CANDU reactor unit using the recently developed software code P-LBB that complies with the requirements of Canadian Nuclear Standard CSA N286.7 for quality assurance of analytical, scientific, and design computer programs for nuclear power plants. This paper discusses the approaches used and the results obtained in the second stage of this pilot study, the uncertainty characterization of influential variables identified as discussed in the companion paper presented at the PVP 2018 Conference (PVP2018-85010). In the proposed methodology, statistical assessment and expert judgment are recognized as two complementary approaches to uncertainty characterization. In this pilot study, the uncertainty characterization was limited to cases where statistical assessment could be used as the primary approach. Parametric uncertainty and uncertainty due to numerical solutions were considered as the uncertainty components for variables represented by parametric models. Residual uncertainty and uncertainty due to imbalances in the model-basis data set were considered as the uncertainty components for variables represented by statistical models. In general, the uncertainty due to numerical solutions was found to be substantially smaller than the parametric uncertainty for variables represented by parametric models, and the uncertainty due to imbalances in the model basis data set was found to be substantially smaller than the residual uncertainty for variables represented by statistical models.


Author(s):  
Christopher Manu ◽  
Suresh Datla ◽  
Leonid Gutkin

Canadian Nuclear Standard CSA N285.8, “Technical requirements for in-service evaluation of zirconium alloy pressure tubes in CANDU® reactors”(1), permits the use of probabilistic methods when performing assessments of the reactor core. A non-mandatory annex has been proposed for inclusion in the CSA Standard N285.8, to provide guidelines for performing uncertainty analysis in probabilistic fitness-for-service evaluations within the scope of this Standard, such as the probabilistic evaluation of leak-before-break. The proposed annex outlines the general approach to uncertainty analysis as being comprised of the following major activities: identification of influential variables, characterization of uncertainties in influential variables, and subsequent propagation of these uncertainties through the evaluation framework or code. The application of the proposed guidelines for uncertainty analysis was exercised by performing a pilot study for one of the evaluations within the scope of the CSA Standard N285.8, the probabilistic evaluation of leak-before-break based on a postulated through-wall crack. The pilot study was performed for a representative CANDU reactor unit using the recently developed computer code P-LBB that complies with requirements of Canadian Nuclear Standard N286.7 for quality assurance of analytical, scientific, and design computer programs for nuclear power plants. This paper discusses the approach used and the results obtained in the first stage of this pilot study, the identification of influential variables. The proposed annex considers three approaches for identifying influential variables, which may be used separately or in combination: analysis of probabilistic evaluation outputs, sensitivity analysis and expert judgment. In this pilot study, local sensitivity analysis was used to identify and rank the influential variables. For each input variable in the probabilistic evaluation of leak-before-break, the local sensitivity coefficient was determined as the relative change in the output variable associated with a relative change of a small magnitude in the input variable. Each input variable was also varied across a large range to assess the linearity of the relationship between the input variable and the output variable. All relevant input variables were ranked according to the absolute value of their sensitivity coefficients to identify the influential variables. On the basis of the results obtained, the pressure tube wall thickness was found to be the most influential variable in the probabilistic evaluation of leak-before-break based on a postulated through-wall crack, followed by the fracture toughness of Zr-2.5Nb pressure tube material and the pressure tube inner diameter. The results obtained at this stage were then used at the second stage of this pilot study, the uncertainty characterization of influential variables, as discussed in the companion paper PVP2018-85011.


1973 ◽  
Vol 37 (11) ◽  
pp. 27-31 ◽  
Author(s):  
G Salvendy ◽  
WM Hinton ◽  
GW Ferguson ◽  
PR Cunningham

2019 ◽  
Vol 62 (9) ◽  
pp. 3397-3412
Author(s):  
Michelle I. Brown ◽  
David Trembath ◽  
Marleen F. Westerveld ◽  
Gail T. Gillon

Purpose This pilot study explored the effectiveness of an early storybook reading (ESR) intervention for parents with babies with hearing loss (HL) for improving (a) parents' book selection skills, (b) parent–child eye contact, and (c) parent–child turn-taking. Advancing research into ESR, this study examined whether the benefits from an ESR intervention reported for babies without HL were also observed in babies with HL. Method Four mother–baby dyads participated in a multiple baseline single-case experimental design across behaviors. Treatment effects for parents' book selection skills, parent–child eye contact, and parent–child turn-taking were examined using visual analysis and Tau-U analysis. Results Statistically significant increases, with large to very large effect sizes, were observed for all 4 participants for parent–child eye contact and parent–child turn-taking. Limited improvements with ceiling effects were observed for parents' book selection skills. Conclusion The findings provide preliminary evidence for the effectiveness of an ESR intervention for babies with HL for promoting parent–child interactions through eye contact and turn-taking.


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