Toxic effects of zinc oxide nanoparticles and histopathological and caspase-9 expression changes in the liver and lung tissues of male mice model

Author(s):  
Ali A. A. Al-Ali ◽  
Shatha Q. Al-Tamimi ◽  
Sami J. Al-Maliki ◽  
Mohd Azmuddin Abdullah
2014 ◽  
Vol 33 (12) ◽  
pp. 2859-2868 ◽  
Author(s):  
Jing Hua ◽  
Martina G. Vijver ◽  
Michael K. Richardson ◽  
Farooq Ahmad ◽  
Willie J.G.M. Peijnenburg

2018 ◽  
Vol 5 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Said Said Elshama ◽  
Metwally E. Abdallah ◽  
Rehab I. Abdel-Karim

Despite the widespread application of zinc oxide nanoparticles in biomedicine, their use is still a controversial issue. Zinc oxide nanoparticles were reported to have therapeutic benefits. However, they were reported to have toxicological hazards as well. Several studies reported the antibacterial, anticancer, antioxidant, and immunomodulatory effects of zinc oxide nanoparticles. Additionally, zinc oxide nanoparticles were used in sunscreens. Furthermore, the ability to use zinc oxide nanoparticles as an adjuvant treatment to alleviate the toxic effects of chemotherapeutic drugs has been reported. However, zinc oxide nanoparticles were shown to induce toxic effects in different body organs and systems. The affected organs included liver, spleen, kidney, stomach, pancreas, heart and lung. In addition, zinc oxide nanoparticles were reported to adversely affect the neurological system, lymphatic system, hematological indices, sex hormones levels, and fetal development. The toxic effects of zinc oxide nanoparticles were based on their concentration, their dose, the route of their administration, and the time of exposure to those particles. Thus, it is crucial to assess their efficacy and safety to determine their toxicological risks and therapeutic benefits.


2018 ◽  
Vol 205 ◽  
pp. 130-139 ◽  
Author(s):  
Ade Yamindago ◽  
Nayun Lee ◽  
Seonock Woo ◽  
Hyosun Choi ◽  
Ji Young Mun ◽  
...  

2015 ◽  
Vol 4 (1) ◽  
pp. 69 ◽  
Author(s):  
Marziyeh Ajdary ◽  
Masoud Negahdary ◽  
Reyhaneh Chelongar ◽  
ShahrzadKabiri zadeh

RSC Advances ◽  
2018 ◽  
Vol 8 (46) ◽  
pp. 26078-26088 ◽  
Author(s):  
Tianjiao Gu ◽  
Chenjie Yao ◽  
Kangkang Zhang ◽  
Chenchen Li ◽  
Lin Ding ◽  
...  

Vitamin C is more powerful than casein phosphopeptides at controlling the combined toxic effects induced by ZnO NPs on gastric epithelium cells and intestinal absorption in mice.


Chemosphere ◽  
2018 ◽  
Vol 193 ◽  
pp. 852-860 ◽  
Author(s):  
Jing Hou ◽  
Yazhou Wu ◽  
Xin Li ◽  
Benben Wei ◽  
Shiguo Li ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document