Circadian rhythm in gastric mucosal blood flow in fasting rat stomach

1991 ◽  
Vol 51 (4) ◽  
pp. 275-280 ◽  
Author(s):  
Kenneth R. Larsen ◽  
Merril T. Dayton ◽  
John G. Moore
1996 ◽  
Vol 271 (6) ◽  
pp. G1028-G1033 ◽  
Author(s):  
H. Nagata ◽  
E. Sekizuka ◽  
T. Morishita ◽  
M. Tatemichi ◽  
T. Kurokawa ◽  
...  

Topical application of ethanol to the gastrointestinal mucosa induces vasodilation. Using an in vivo microscopy technique, we studied the effect of topical ethanol on the submucosal microvessels that control mucosal blood flow in the rat stomach and identified vasoactive substances and receptors that mediate the ethanol vasoaction. Topical ethanol (1-20%) dilated submucosal arterioles dose dependently, but did not change venular diameters. An inhibitor of alcohol dehydrogenase, 1 mM 4-methylpyrazole, did not alter the ethanol vasoaction. Ethanol-induced arteriolar dilation was eliminated by adenosine deaminase, but other vasodilator inhibitors such as atropine, pyrilamine, indomethacin, human calcitonin gene-related peptide-(8-37), and N omega-nitro-L-arginine methyl ester did not prevent it. Ethanol-induced arteriolar dilation was inhibited by an adenosine A2-receptor antagonist, but not by an A1-receptor antagonist, whereas an A2-agonist, but not an A1-agonist, dose dependently dilated arterioles. Exogenous adenosine (10(-5)-10(-3) M) dilated arterioles to a similar extent as ethanol. This response was inhibited by an A2-antagonist. We conclude that nonmetabolized ethanol increases gastric mucosal blood flow via A2-receptors in submucosal arterioles.


1988 ◽  
Vol 254 (4) ◽  
pp. G566-G574
Author(s):  
W. J. Angerson ◽  
J. G. Geraghty ◽  
D. C. Carter

Iodo[14C]antipyrine autoradiography was used to measure gastric mucosal blood flow in anesthetized rats and to study regional distribution. Blood flows of 61 +/- 8 ml.100 g-1.min-1 (means +/- SE) in corpus and 84 +/- 9 ml.100 g-1.min-1 in antral mucosa compared well with previously reported measurements by hydrogen clearance. Blood flow in the crests of corpus mucosal folds was significantly higher than in the valleys between folds, indicating that the greater susceptibility of the former areas to acute injury, documented in several studies, is not associated with a perfusion defect in the resting stomach. Corpus mucosal blood flow was also higher in the side walls of the stomach than in the greater curvature region, and in distal than in proximal locations. No systematic regional variations within antral mucosa were demonstrated.


1991 ◽  
Vol 3 (4) ◽  
pp. 513-518 ◽  
Author(s):  
Tadatoshi TSUCHIGAME ◽  
Kohshiro ITOH ◽  
Masafumi HAR ◽  
Okimitsu WATANABE ◽  
Youichi OHYAMA ◽  
...  

1985 ◽  
Vol 38 (5) ◽  
pp. 416-423 ◽  
Author(s):  
Stanley W. Ashley ◽  
Zhong-Yu Yan ◽  
David I. Soybel ◽  
Laurence Y. Cheung

1988 ◽  
Vol 95 (3) ◽  
pp. 642-650 ◽  
Author(s):  
Josep M. Pique ◽  
Felix W. Leung ◽  
Heck W. Tan ◽  
Edward Livingston ◽  
Oscar U. Scremin ◽  
...  

Digestion ◽  
2009 ◽  
Vol 79 (2) ◽  
pp. 73-78 ◽  
Author(s):  
Motonori Sato ◽  
Noriaki Manabe ◽  
Jiro Hata ◽  
Manabu Ishii ◽  
Tomoari Kamada ◽  
...  

1975 ◽  
Vol 69 (4) ◽  
pp. 935-940 ◽  
Author(s):  
Paul H. Guth ◽  
Esther Smith

1987 ◽  
Vol 205 (4) ◽  
pp. 399-403 ◽  
Author(s):  
THEOPHILUS J. GANA ◽  
ROMAN HUHLEWYCH ◽  
JARLEY KOO

Sign in / Sign up

Export Citation Format

Share Document