Effect of a neurokinin-1 (NK1) receptor antagonist on oedema formation induced by tachykinins, carrageenin and an allergic response in guinea-pig skin

Discovery and Biological Characterization of (2R,4S)-1′-Acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4′-bipiperidine-1-carboxamide as a New Potent and Selective Neurokinin 1 (NK1) Receptor Antagonist Clinical Candidate

Journal of Medicinal Chemistry ◽

10.1021/jm1013264 ◽

2011 ◽

Vol 54 (4) ◽

pp. 1071-1079 ◽

Cited By ~ 22

Author(s):

Romano Di Fabio ◽

Giuseppe Alvaro ◽

Cristiana Griffante ◽

Domenica A. Pizzi ◽

Daniele Donati ◽

...

Keyword(s):

Receptor Antagonist ◽

Nk1 Receptor ◽

Biological Characterization ◽

Nk1 Receptor Antagonist ◽

Neurokinin 1 ◽

Clinical Candidate

Efficacy and safety of casopitant mesylate, a neurokinin 1 (NK1)-receptor antagonist, in prevention of chemotherapy-induced nausea and vomiting in patients receiving cisplatin-based highly emetogenic chemotherapy: a randomised, double-blind, placebo-controlled trial

The Lancet Oncology ◽

10.1016/s1470-2045(09)70109-3 ◽

2009 ◽

Vol 10 (6) ◽

pp. 549-558 ◽

Cited By ~ 55

Author(s):

Steven M Grunberg ◽

Janusz Rolski ◽

Janos Strausz ◽

Zeba Aziz ◽

Stephen Lane ◽

...

Keyword(s):

Receptor Antagonist ◽

Controlled Trial ◽

Emetogenic Chemotherapy ◽

Efficacy And Safety ◽

Nk1 Receptor ◽

Highly Emetogenic Chemotherapy ◽

Double Blind ◽

Double Blind Placebo ◽

Nk1 Receptor Antagonist ◽

Effect of CP-96,345, a non-peptide NK1 receptor antagonist, against substance P-, bradykinin- and allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig

European Journal of Pharmacology ◽

10.1016/0014-2999(93)90680-g ◽

1993 ◽

Vol 231 (1) ◽

pp. 31-38 ◽

Cited By ~ 49

Author(s):

Tatsuo Sakamoto ◽

Peter J. Barnes ◽

K. Fan Chung

Keyword(s):

Substance P ◽

Guinea Pig ◽

Receptor Antagonist ◽

Nk1 Receptor ◽

Microvascular Leakage ◽

The effect of a tachykinin NK1 receptor antagonist, SR140333, on oedema formation induced in rat skin by venom from the Phoneutria nigriventer spider

British Journal of Pharmacology ◽

10.1111/j.1476-5381.1996.tb15402.x ◽

1996 ◽

Vol 118 (2) ◽

pp. 295-298 ◽

Cited By ~ 33

Author(s):

R.T. Palframan ◽

S.K.P. Costa ◽

P. Wilsoncroft ◽

E. Antunes ◽

G. Nucci ◽

...

Keyword(s):

Receptor Antagonist ◽

Nk1 Receptor ◽

Rat Skin ◽

Oedema Formation ◽

Nk1 Receptor Antagonist ◽

Phoneutria Nigriventer

Effects of an NK1 receptor antagonist, FK888, on constriction and plasma extravasation induced in guinea pig airway by neurokinins and capsaicin

European Journal of Pharmacology ◽

10.1016/0014-2999(93)90220-c ◽

1993 ◽

Vol 236 (1) ◽

pp. 7-13 ◽

Cited By ~ 19

Author(s):

Masako Murai ◽

Yasue Maeda ◽

Daijiro Hagiwara ◽

Hiroshi Miyake ◽

Norihiro Ikari ◽

...

Keyword(s):

Guinea Pig ◽

Receptor Antagonist ◽

Plasma Extravasation ◽

Nk1 Receptor ◽

Effects of antidepressant drugs and GR 205171, an neurokinin-1 (NK1) receptor antagonist, on the response in the forced swim test and on monoamine extracellular levels in the frontal cortex of the mouse

Neuroscience Letters ◽

10.1016/s0304-3940(03)00305-7 ◽

2003 ◽

Vol 345 (2) ◽

pp. 73-76 ◽

Cited By ~ 48

Author(s):

Alessandro Zocchi ◽

Giorgia Varnier ◽

Roberto Arban ◽

Cristiana Griffante ◽

Lara Zanetti ◽

...

Keyword(s):

Frontal Cortex ◽

Receptor Antagonist ◽

Forced Swim Test ◽

Antidepressant Drugs ◽

Nk1 Receptor ◽

Swim Test ◽

Forced Swim ◽

Nk1 Receptor Antagonist ◽

Inhibition of neurogenic plasma exudation in guinea-pig airways by CP-96,345, a new non-peptide NK1 receptor antagonist

British Journal of Pharmacology ◽

10.1111/j.1476-5381.1992.tb14243.x ◽

1992 ◽

Vol 105 (2) ◽

pp. 261-262 ◽

Cited By ~ 77

Author(s):

Yu-Hong Lei ◽

Peter J. Barnes ◽

Duncan F. Rogers

Keyword(s):

Guinea Pig ◽

Receptor Antagonist ◽

Nk1 Receptor ◽

Nk1 Receptor Antagonist ◽

Plasma Exudation

The selective tachykinin neurokinin 1 (NK1) receptor antagonist, GR 205,171, stereospecifically inhibits light-induced phase advances of hamster circadian activity rhythms

European Journal of Pharmacology ◽

10.1016/j.ejphar.2005.10.012 ◽

2005 ◽

Vol 527 (1-3) ◽

pp. 86-93 ◽

Cited By ~ 10

Author(s):

Robert L. Gannon ◽

Mark J. Millan

Keyword(s):

Receptor Antagonist ◽

Circadian Activity ◽

Nk1 Receptor ◽

Activity Rhythms ◽

Nk1 Receptor Antagonist ◽

Characterization and autoradiographic mapping of [3H]CP96,345, a nonpeptide selective NK1 receptor antagonist in guinea pig lung

Peptides ◽

10.1016/0196-9781(95)00052-l ◽

1995 ◽

Vol 16 (5) ◽

pp. 867-872 ◽

Cited By ~ 9

Author(s):

Xiao-Ling Zhang ◽

Judith C.W. Mak ◽

Peter J. Barnes

Keyword(s):

Guinea Pig ◽

Receptor Antagonist ◽

Nk1 Receptor ◽

Blockade by oral or parenteral RPR 100893 (a non-peptide NK1 receptor antagonist) of neurogenic plasma protein extravasation within guinea-pig dura mater and conjunctiva

British Journal of Pharmacology ◽

10.1111/j.1476-5381.1994.tb13168.x ◽

1994 ◽

Vol 112 (3) ◽

pp. 920-924 ◽

Cited By ~ 48

Author(s):

Won S. Lee ◽

Saliha M. Moussaoui ◽

Michael A. Moskowitz

Keyword(s):

Guinea Pig ◽

Receptor Antagonist ◽

Dura Mater ◽

Plasma Protein ◽

Nk1 Receptor ◽

Protein Extravasation ◽

Plasma Protein Extravasation ◽