The role of radiotherapy in the treatment and prevention of local-regional recurrence following mastectomy for operable breast cancer

1986 ◽  
Vol 12 (12) ◽  
pp. 2209-2210 ◽  
Author(s):  
Barbara Danoff Fowble
Keyword(s):  
Breast Cancer ◽  
Operable Breast Cancer ◽  
Regional Recurrence ◽  
Treatment And Prevention ◽  
Local Regional Recurrence

Isolated local regional recurrence (ILR) in operable breast cancer: How common is the problem?

1998 ◽  
Vol 42 (1) ◽  
pp. 251
Author(s):  
Whelan Timothy ◽  
Julian Jim ◽  
Levine Mark ◽  
Chambers Shelley ◽  
Bramwell Vivian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Operable Breast Cancer ◽  
Regional Recurrence ◽  
Local Regional Recurrence

scholarly journals Prognostic Factors of Local-Regional Recurrence in Patients with Operable Breast Cancer in Asia: A Meta-Analysis

2019 ◽  
Vol 7 (4) ◽  
pp. 690-695 ◽  
Author(s):  
Wirsma Arif Harahap ◽  
Ricvan Dana Nindrea
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Tumor Size ◽  
Meta Analysis ◽  
Random Effect ◽  
Tumor Grade ◽  
Operable Breast Cancer ◽  
Regional Recurrence ◽  
N Stage ◽  
Local Regional Recurrence

BACKGROUND: Cause of recurrence of breast cancer is multifactorial. Also, the occurrence of breast cancer in Asian patients has some different factors from the recurrence of breast cancer in western countries. AIM: This study aims to determine the prognostic factors of local-regional recurrence in patients with operable breast cancer in Asia. METHODS: The authors conducted a meta-analysis of published research articles published in an online database of PubMed, ProQuest and EBSCO between January 2000 and July 2018. Pooled risk ratios (RR) were calculated using fixed and random-effect models. Data were processed by using Review Manager 5.3 (RevMan 5.3). RESULTS: This study reviewed 879 articles. There were 11 studies conducted a systematic review then continued by meta-analysis of relevant data with total patients involved were 5,213 patients. The prognostic factors found of local-regional recurrence in patients with operable breast cancer were Nodal (N) stage with the highest risk ratio (RR = 6.35 [95% CI 3.78-10.67]) followed by HER2 positive (RR = 2.14 [95% CI 1.16-3.97]), stage of cancer (RR = 1.82 [95% CI 1.44-2.31]), tumor size (RR = 1.55 [95% CI 1.04-2.31]), tumor grade (RR = 1.43 [95% CI 1.23-1.65]), PR status (RR = 0.65 [95% CI 0.48-0.88]) and the least was ER status (RR = 0.60 [95% CI 0.39-0.91]). Homogeneity of variance was found in N stage, tumor size and tumor grade for recurrence of operable breast cancer. CONCLUSION: This meta-analysis confirmed the correlation of N stage, HER2, stage of cancer, tumour size, tumour grade, ER and PR status with recurrence in patients with operable breast cancer in Asia.

First repeated bone scan in the observation of patients with operable breast cancer.

1986 ◽  
Vol 4 (3) ◽  
pp. 389-394 ◽  
Author(s):  
A Pedrazzini ◽  
R Gelber ◽  
M Isley ◽  
M Castiglione ◽  
A Goldhirsch
Keyword(s):  
Breast Cancer ◽  
Alkaline Phosphatase ◽  
Bone Scan ◽  
Serum Alkaline Phosphatase ◽  
Clinical Situation ◽  
Operable Breast Cancer ◽  
First Relapse ◽  
Bone Scans ◽  
First Recurrence

Data on 1,601 patients with node-positive operable breast cancer who were randomized in four different prospective adjuvant therapy trials were analyzed to evaluate the role of routine bone scans and the alkaline phosphatase value at regular intervals in screening for bone involvement. Bone scan was a prerequisite for randomization and was repeated within the first 12 months in 90% (1,441) of the patients. Abnormal or doubtful scan findings had to be verified by x-ray examination. The repeated scan results were normal in 1,263 (87.8%) patients, doubtful but with no radiologic evidence of bone metastasis in 161 (11%), and abnormal (radiologically confirmed) in 17 (1.2%). After a median observation of 4 years bone metastases as the first relapse developed in 136 (8.5%) patients. This occurred in 87 of 1,263 (6.9%) of the patients with normal repeated scan results and in 18 of 161 (11.2%) of those with doubtful repeated scan findings. Based on the results of the first repeated scan, early detection of a first recurrence in bone might have been possible for 2.4% of the population. Serum alkaline phosphatase levels were also without clinical use. Bone scan in the observation of patients with operable breast cancer should be performed only as dictated by the clinical situation.

The role of axillary dissection in operable breast cancer

The Breast ◽  
1992 ◽  
Vol 1 (1) ◽  
pp. 41-49 ◽  
Author(s):  
N.P.M. Sacks ◽  
L.C. Barr ◽  
S.M. Allan ◽  
M. Baum
Keyword(s):  
Breast Cancer ◽  
Axillary Dissection ◽  
Operable Breast Cancer
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