Kinesin Superfamily Proteins

2021 ◽  
Author(s):  
Nobutaka Hirokawa ◽  
Yosuke Tanaka ◽  
Reiko Takemura
Keyword(s):  
Kinesin Superfamily

scholarly journals A standardized kinesin nomenclature

2004 ◽  
Vol 167 (1) ◽  
pp. 19-22 ◽  
Author(s):  
Carolyn J. Lawrence ◽  
R. Kelly Dawe ◽  
Karen R. Christie ◽  
Don W. Cleveland ◽  
Scott C. Dawson ◽  
...  
Keyword(s):  
Kinesin Superfamily

In recent years the kinesin superfamily has become so large that several different naming schemes have emerged, leading to confusion and miscommunication. Here, we set forth a standardized kinesin nomenclature based on 14 family designations. The scheme unifies all previous phylogenies and nomenclature proposals, while allowing individual sequence names to remain the same, and for expansion to occur as new sequences are discovered.

scholarly journals Expression of kinesin superfamily genes in cultured hippocampal neurons

Cytoskeleton ◽  
2010 ◽  
Vol 67 (12) ◽  
pp. 784-795 ◽  
Author(s):  
M. A. Silverman ◽  
S. Kaech ◽  
E. M. Ramser ◽  
X. Lu ◽  
M. R. Lasarev ◽  
...  
Keyword(s):  
Hippocampal Neurons ◽  
Kinesin Superfamily ◽  
Cultured Hippocampal Neurons

Interaction between GADD34 and Kinesin Superfamily, KIF3A

2000 ◽  
Vol 267 (2) ◽  
pp. 593-596 ◽  
Author(s):  
Tadao Hasegawa ◽  
Ayako Yagi ◽  
Ken-ichi Isobe
Keyword(s):  
Kinesin Superfamily

scholarly journals Parts list for a microtubule depolymerising kinesin

2018 ◽  
Vol 46 (6) ◽  
pp. 1665-1672 ◽  
Author(s):  
Claire T. Friel ◽  
Julie P. Welburn
Keyword(s):  
Chromosome Segregation ◽  
Molecular Motors ◽  
Neuronal Development ◽  
Current Understanding ◽  
Cellular Functions ◽  
Microtubule Cytoskeleton ◽  
Microtubule Binding ◽  
Large Group ◽  
Kinesin Superfamily ◽  
Different Parts

The Kinesin superfamily is a large group of molecular motors that use the turnover of ATP to regulate their interaction with the microtubule cytoskeleton. The coupled relationship between nucleotide turnover and microtubule binding is harnessed in various ways by these motors allowing them to carry out a variety of cellular functions. The Kinesin-13 family is a group of specialist microtubule depolymerising motors. Members of this family use their microtubule destabilising activity to regulate processes such as chromosome segregation, maintenance of cilia and neuronal development. Here, we describe the current understanding of the structure of this family of kinesins and the role different parts of these proteins play in their microtubule depolymerisation activity and in the wider function of this family of kinesins.

scholarly journals Kinesin superfamily protein 21B acts as an oncogene in non-small cell lung cancer

2020 ◽  
Author(s):  
Zhi-Gang Sun ◽  
Feng Pan ◽  
Jing-Bo Shao ◽  
Qian-Qian Yan ◽  
Lu Lu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Nude Mice ◽  
Cell Lung Cancer ◽  
A549 Cells ◽  
Small Cell ◽  
Normal Lung ◽  
Migration And Invasion ◽  
Small Cell Lung ◽  
Kinesin Superfamily

Abstract Background: Kinesin superfamily proteins (KIFs) serve as microtubule-dependent molecular motors, and are involved in the progression of many malignant tumors. In this study, we aimed to investigate the expression pattern and precise role of kinesin family member 21B (KIF21B) in non-small cell lung cancer (NSCLC). Methods: KIF21B expression in 72 cases of NSCLC tissues was measured by immunohistochemical staining (IHC). We used shRNA-KIF21B interference to silence KIF21B in NSCLC H1299 and A549 cells and normal lung epithelial bronchus BEAS-2B cells. The biological roles of KIF21B in the growth and metastasis abilities of NSCLC cells were measured by Cell Counting Kit-8 (CCK8), colony formation and Hoechst 33342/PI, wound-healing, and Transwell assays, respectively. Expression of apoptosis-related proteins was determined using western blot. The effect of KIF21B on tumor growth in vivo was examined using nude mice model. Results: KIF21B was up-regulated in NSCLC tissues, and correlated with pathological lymph node and pTNM stage, its high expression was predicted a poor prognosis of patients with NSCLC. Silencing of KIF21B mediated by lentivirus-delivered shRNA significantly inhibited the proliferation ability of H1299 and A549 cells. KIF21B knockdown increased apoptosis in H1299 and A549 cells, down-regulated the expression of Bcl-2 and up-regulated the expression of Bax and active Caspase 3. Moreover, KIF21B knockdown decreased the level of phosphorylated form of Akt (p-Akt) and Cyclin D1 expression in H1299 and A549 cells. In addition, silencing of KIF21B impeded the migration and invasion of H1299 and A549 cells. Further, silencing of KIF 21B dramatically inhibited xenograft growth in BALB/c nude mice. However, silencing of KIF21B did not affect the proliferation, migration and invasion of BEAS-2B cells.Conclusions: These results reveal that KIF21B is up-regulated in NSCLC and acts as an oncogene in the growth and metastasis of NSCLC, which may function as a potential therapeutic target and a prognostic biomarker for NSCLC.

scholarly journals Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Tian-Fu Li ◽  
Hui-Juan Zeng ◽  
Zhen Shan ◽  
Run-Yi Ye ◽  
Tuck-Yun Cheang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Biomarkers ◽  
Kinesin Superfamily

The Presence of Kinesin Superfamily Motor Proteins KIFC1 and KIF17 in Normal and Pathological Human Placenta

Placenta ◽  
2009 ◽  
Vol 30 (10) ◽  
pp. 848-854 ◽  
Author(s):  
L. Sati ◽  
Y. Seval-Celik ◽  
G. Unek ◽  
E.T. Korgun ◽  
R. Demir
Keyword(s):  
Human Placenta ◽  
Motor Proteins ◽  
Kinesin Superfamily
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