Bioanalytical methods: Technological platforms and method validation

2022 ◽  
pp. 169-187
Author(s):  
Mark E. Arnold ◽  
Brian Booth
Bioanalysis ◽  
2020 ◽  
Vol 12 (24) ◽  
pp. 1767-1786
Author(s):  
Mohsin Ali ◽  
Muhammad Usman ◽  
Huma Rasheed ◽  
Georg Hempel ◽  
Hafiz A Nawaz ◽  
...  

A fully validated bioanalytical methods are prerequisite for pharmacokinetic and bioequivalence studies as well as for therapeutic drug monitoring. Due to high pharmacokinetic variability and narrow therapeutic index, vancomycin requires reliable quantification methods for therapeutic drug monitoring. To identify published chromatographic based bioanalytical methods for vancomycin in current systematic review, PubMed and ScienceDirect databases were searched. The selected records were evaluated against the method validation criteria derived from international guidelines for critical assessment. The major deficiencies were identified in method validation parameters specifically for accuracy, precision and number of calibration and validation standards, which compromised the reliability of the validated bioanalytical methods. The systematic review enacts to adapt the recommended international guidelines for suggested validation parameters to make bioanalysis reliable.


2018 ◽  
Vol 2 (2) ◽  
pp. 70-82 ◽  
Author(s):  
Binglu Wang ◽  
Yi Bu ◽  
Win-bin Huang

AbstractIn the field of scientometrics, the principal purpose for author co-citation analysis (ACA) is to map knowledge domains by quantifying the relationship between co-cited author pairs. However, traditional ACA has been criticized since its input is insufficiently informative by simply counting authors’ co-citation frequencies. To address this issue, this paper introduces a new method that reconstructs the raw co-citation matrices by regarding document unit counts and keywords of references, named as Document- and Keyword-Based Author Co-Citation Analysis (DKACA). Based on the traditional ACA, DKACA counted co-citation pairs by document units instead of authors from the global network perspective. Moreover, by incorporating the information of keywords from cited papers, DKACA captured their semantic similarity between co-cited papers. In the method validation part, we implemented network visualization and MDS measurement to evaluate the effectiveness of DKACA. Results suggest that the proposed DKACA method not only reveals more insights that are previously unknown but also improves the performance and accuracy of knowledge domain mapping, representing a new basis for further studies.


Sign in / Sign up

Export Citation Format

Share Document