Circumventing immune rejection and foreign body response to therapeutics of type 1 diabetes

2021 ◽  
pp. 215-250
Author(s):  
Stuart J. Bauer ◽  
Joshua C. Doloff
Keyword(s):  
Type 1 Diabetes ◽  
Foreign Body ◽  
Foreign Body Response ◽  
Immune Rejection ◽  
Body Response

850-P: Continued Monitoring of the Foreign-Body Response to Improve Long-Term Success of Macroencapsulation Devices for Type 1 Diabetes: A Proof-of-Concept Study

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 850-P
Author(s):  
RACHEL M. BEATTY ◽  
EIMEAR B. DOLAN ◽  
SCOTT T. ROBINSON ◽  
RAYMOND OCONNOR ◽  
ROBERT WYLIE ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Foreign Body ◽  
Foreign Body Response ◽  
Proof Of Concept ◽  
Concept Study ◽  
Body Response

Examinations of a new long-term degradable electrospun polycaprolactone scaffold in three rat abdominal wall models

2017 ◽  
Vol 31 (7) ◽  
pp. 1077-1086 ◽  
Author(s):  
Hanna Jangö ◽  
Søren Gräs ◽  
Lise Christensen ◽  
Gunnar Lose
Keyword(s):  
Pelvic Organ Prolapse ◽  
Foreign Body ◽  
Abdominal Wall ◽  
Muscle Fiber ◽  
Pelvic Organ ◽  
Foreign Body Response ◽  
Heavy Load ◽  
Tissue Construct ◽  
Body Response

Alternative approaches to reinforce native tissue in reconstructive surgery for pelvic organ prolapse are warranted. Tissue engineering combines the use of a scaffold with the regenerative potential of stem cells and is a promising new concept in urogynecology. Our objective was to evaluate whether a newly developed long-term degradable polycaprolactone scaffold could provide biomechanical reinforcement and function as a scaffold for autologous muscle fiber fragments. We performed a study with three different rat abdominal wall models where the scaffold with or without muscle fiber fragments was placed (1) subcutaneously (minimal load), (2) in a partial defect (partial load), and (3) in a full-thickness defect (heavy load). After 8 weeks, no animals had developed hernia, and the scaffold provided biomechanical reinforcement, even in the models where it was subjected to heavy load. The scaffold was not yet degraded but showed increased thickness in all groups. Histologically, we found a massive foreign body response with numerous large giant cells intermingled with the fibers of the scaffold. Cells from added muscle fiber fragments could not be traced by PKH26 fluorescence or desmin staining. Taken together, the long-term degradable polycaprolactone scaffold provided biomechanical reinforcement by inducing a marked foreign-body response and attracting numerous inflammatory cells to form a strong neo-tissue construct. However, cells from the muscle fiber fragments did not survive in this milieu. Properties of the new neo-tissue construct must be evaluated at the time of full degradation of the scaffold before its possible clinical value in pelvic organ prolapse surgery can be evaluated.

Mitigating the foreign body response through ‘immune-instructive’ biomaterials

2021 ◽  
Vol 12 ◽  
pp. 100040
Author(s):  
Lisa Kämmerling ◽  
Leanne E. Fisher ◽  
Ezgi Antmen ◽  
Gorkem M. Simsek ◽  
Hassan M. Rostam ◽  
...  
Keyword(s):  
Foreign Body ◽  
Foreign Body Response ◽  
Body Response

scholarly journals A Polymer-Biologic Hybrid Hernia Construct: Review of Data and Early Experiences

Polymers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 1928
Author(s):  
Michael Sawyer ◽  
Stephen Ferzoco ◽  
George DeNoto
Keyword(s):  
Foreign Body ◽  
Hernia Repair ◽  
Surgical Mesh ◽  
Foreign Body Response ◽  
Host Cells ◽  
Mesh Reinforcement ◽  
Decellularized Extracellular Matrix ◽  
Early Experiences ◽  
Tissue Matrix ◽  
Body Response

Surgical mesh reinforcement of the human abdominal wall has been found to reduce the chance of recurrence in hernia repairs. While traditionally polymer meshes have been used in hernia repair, alternative mesh options have been engineered to prevent the inflammatory foreign body response invoked by polymers. A reinforced tissue matrix (RTM) mesh has been developed by embedding a polymer within a decellularized extracellular matrix. This combination has been attributed to the recruitment of host cells, a pro-healing response, and attenuation of the foreign body response. This has been observed to lead to the regeneration of functional tissue within the repair site that is reinforced by the polymer to offload abdominal pressures over time. This manuscript presents the review of OviTex, an RTM, in several types of hernia repair. The authors have found that the use of RTM in hernia repair is effective in preventing foreign body response, promoting wound healing, and providing reinforcement to lower the risk of hernia recurrence.

scholarly journals Immunobiology and Application of Aloe vera-Based Scaffolds in Tissue Engineering

2021 ◽  
Vol 22 (4) ◽  
pp. 1708
Author(s):  
Saeedeh Darzi ◽  
Kallyanashis Paul ◽  
Shanilka Leitan ◽  
Jerome A. Werkmeister ◽  
Shayanti Mukherjee
Keyword(s):  
Tissue Engineering ◽  
Foreign Body ◽  
Scientific Evidence ◽  
Aloe Vera ◽  
Material Design ◽  
Foreign Body Response ◽  
The Body ◽  
Design Strategies ◽  
Immunomodulatory Effects ◽  
Body Response

Aloe vera (AV), a succulent plant belonging to the Liliaceae family, has been widely used for biomedical and pharmaceutical application. Its popularity stems from several of its bioactive components that have anti-oxidant, anti-microbial, anti-inflammatory and even immunomodulatory effects. Given such unique multi-modal biological impact, AV has been considered as a biomaterial for regenerative medicine and tissue engineering applications, where tissue repair and neo-angiogenesis are vital. This review outlines the growing scientific evidence that demonstrates the advantage of AV as tissue engineering scaffolds. We particularly highlight the recent advances in the application of AV-based scaffolds. From a tissue engineering perspective, it is pivotal that the implanted scaffolds strike an appropriate foreign body response to be well-accepted in the body without complications. Herein, we highlight the key cellular processes that regulate the foreign body response to implanted scaffolds and underline the immunomodulatory effects incurred by AV on the innate and adaptive system. Given that AV has several beneficial components, we discuss the importance of delving deeper into uncovering its action mechanism and thereby improving material design strategies for better tissue engineering constructs for biomedical applications.

Foreign body response to subcutaneous biomaterial implants in a mast cell-deficient Kitw-Sh murine model

2014 ◽  
Vol 10 (5) ◽  
pp. 1856-1863 ◽  
Author(s):  
M.N. Avula ◽  
A.N. Rao ◽  
L.D. McGill ◽  
D.W. Grainger ◽  
F. Solzbacher
Keyword(s):  
Mast Cell ◽  
Foreign Body ◽  
Murine Model ◽  
Foreign Body Response ◽  
Body Response
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