Novel pyrethroid derivatives as effective mosquito repellents and repellent synergists

2022 ◽  
pp. 19-32
Author(s):  
Jeffrey Bloomquist ◽  
Shiyao Jiang ◽  
Edmund Norris ◽  
Gary Richoux ◽  
Liu Yang ◽  
...  
Keyword(s):  
Mosquito Repellents

Computational Approaches for the Design of Mosquito Repellent Chemicals

2020 ◽  
Vol 27 (1) ◽  
pp. 32-41 ◽  
Author(s):  
Subhash C. Basak ◽  
Apurba K. Bhattacharjee
Keyword(s):  
Computational Design ◽  
Quantitative Structure Activity Relationship ◽  
Computer Assisted ◽  
Quantitative Structure ◽  
Mosquito Repellent ◽  
Computational Approaches ◽  
Qsar Studies ◽  
Computer Assisted Design ◽  
Structure Activity ◽  
Mosquito Repellents

Background: In view of many current mosquito-borne diseases there is a need for the design of novel repellents. Objective: The objective of this article is to review the results of the researches carried out by the authors in the computer-assisted design of novel mosquito repellents. Methods: Two methods in the computational design of repellents have been discussed: a) Quantitative Structure Activity Relationship (QSAR) studies from a set of repellents structurally related to DEET using computed mathematical descriptors, and b) Pharmacophore based modeling for design and discovery of novel repellent compounds including virtual screening of compound databases and synthesis of novel analogues. Results: Effective QSARs could be developed using mathematical structural descriptors. The pharmacophore based method is an effective tool for the discovery of new repellent molecules. Conclusion: Results reviewed in this article show that both QSAR and pharmacophore based methods can be used to design novel repellent molecules.

Studies on the Responses of the Female Aëdes Mosquito. Part II.—The Action of Liquid Repellent Compounds

1951 ◽  
Vol 42 (1) ◽  
pp. 115-122 ◽  
Author(s):  
D. S. Sarkaria ◽  
A. W. A. Brown
Keyword(s):  
Aedes Aegypti ◽  
Volatile Compounds ◽  
Vapour Pressure ◽  
Aedes Mosquito ◽  
Large Cage ◽  
Mosquito Repellents ◽  
Protection Period

A number of liquid mosquito repellents were assessed for vapour repellency power in an olfactometer mounted in a very large cage filled with females of Aëdes aegypti. They were also tested for their knockdown power in fumigation bottles. Their vapour pressures were determined by the Ramsay-Young method.All the liquids showed vapour repellency, and in 39 out of the 42 tested this effect was highly significant. The highest vapour repellency ratings were shown by compounds already known to be the most effective repellents.Although the more volatile compounds such as citronellal tend to show the highest repellency ratings, nevertheless compounds of low vapour pressure such as indalone, DMP and isobornyl morpholinoacetate may also show high vapour repellency. It is concluded that vapour repellency, although in the first instance dependent upon volatility, can vary independently of vapour pressure, so that compounds may be found which afford not only a long protection period due to their nonvolatility, but also a high vapour repellency due to the potency of the comparatively few molecules that are volatilised.The vapours of most of the repellents were found to induce knockdown of mosquitos, but there was no correlation between the speed of this process and the vapour repellency of the compounds.

Chirality index, molecular overlay and biological activity of diastereoisomeric mosquito repellents

2005 ◽  
Vol 61 (12) ◽  
pp. 1193-1201 ◽  
Author(s):  
Ramanathan Natarajan ◽  
Subhash C Basak ◽  
Alexandru T Balaban ◽  
Jerome A Klun ◽  
Walter F Schmidt
Keyword(s):  
Biological Activity ◽  
Chirality Index ◽  
Mosquito Repellents ◽  
Molecular Overlay

pHEMA hydrogels with pendant triazinyl-β-cyclodextrin as an efficient and recyclable reservoir for loading and release of plant-based mosquito repellents: a new aqueous mosquito repellent formulation

RSC Advances ◽  
2016 ◽  
Vol 6 (33) ◽  
pp. 27301-27312 ◽  
Author(s):  
Wang Delong ◽  
Ma Weibin ◽  
Jia Mingchen ◽  
Yang Zhonglin ◽  
Feng Juntao ◽  
...  
Keyword(s):  
Hydroxyethyl Methacrylate ◽  
Mosquito Repellent ◽  
Mosquito Repellents

Poly(2-hydroxyethyl methacrylate) hydrogels with pendant β-cyclodextrins as an efficient and recyclable reservoir for loading and release of plant-based mosquito repellents.

scholarly journals Health hazard of using mosquito repellent in Khulna city, Bangladesh

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Muniva Islam ◽  
Mohammed Ziaul Haider ◽  
Sk. Faijan Bin Halim
Keyword(s):  
Respiratory Diseases ◽  
Health Hazard ◽  
Health Effect ◽  
Harmful Effect ◽  
Sampling Technique ◽  
Systematic Sampling ◽  
Content Type ◽  
Weather Patterns ◽  
Negative Health Effect ◽  
Mosquito Repellents

PurposeMosquito problem per se arises with diverse weather patterns. With regard to mosquito diseases, people intrinsically use repellents regardless of the harmful effect. The use of repellents like coil, spray, liquid vaporizer and mosquito cream triggers indoor congestion, and thereby respiratory diseases. Eventually, people have to bear high out-of-pocket costs.Design/methodology/approachThis study has applied a stratified systematic sampling technique taking 120 adult individuals from residential and slum areas covering users and non-users of mosquito repellents of Khulna city, Bangladesh. A structured questionnaire has been used to collect data from respondents.FindingsEconometric techniques are exercised to examine the occurrence, severity and duration of different respiratory diseases. Results exhibit that poor and less-educated slum people are more prone to face respiratory diseases compared to residential people. The health cost of slum and residential people is estimated US$ 134 and US$ 9, respectively.Originality/valueFinally, this study underpins arranging public health programs and taking averting actions as an impetus to raise consciousness toward the negative health effect of using mosquito repellents.

scholarly journals A Milestone In Botanical Mosquito Repellents: Novel PMD-Based Formulation Protects More Than Twice As Long As High-Concentration Deet and Other Leading Products

2019 ◽  
Vol 35 (3) ◽  
pp. 186-191 ◽  
Author(s):  
Scott P. Carroll ◽  
Jeffrey Venturino ◽  
John H. Davies
Keyword(s):  
High Performance ◽  
Personal Protection ◽  
Prolonged Action ◽  
High Concentration ◽  
Current Standard ◽  
Protection Time ◽  
Practical Strategy ◽  
Control And Prevention ◽  
The Usa ◽  
Mosquito Repellents

ABSTRACT The use of skin-applied repellents is the primary method recommended by the Centers for Disease Control and Prevention for personal protection against biting mosquitoes. Historically, the majority of long-efficacy mosquito repellents have been N,N diethyl-3-methylbenzamide (deet)–based. Recently, a variety of new botanical formulations have been marketed, but their protection times generally continue to fall well short of high-concentration deet products. We present a laboratory arm-in-cage study of a Neo-Innova® repellent that has a prolonged action “NEO-PART®” (Prolonged Action Release Technology) formulation with 40% Citriodiol®. This formulation provides the botanical molecule para-menthane 3,8-diol (PMD) at 25% w/v of the total formulation. Against Aedes aegypti, Neo-Innova's mean complete protection time (CPT; 14.2 h) was approximately 2 to 3 times longer than that of 5 leading high-performance repellents marketed in the USA, including 25% deet and a 20% PMD ethanolic formulation. When testing Neo-Innova, 5 of the 6 subjects had no landings after 15 h. The 6th had single landings at 10 and 11 h (individual CPT of 10 h), but received no additional landings in further exposures made at 13 and 15 h. Neo-Innova repellency against Culex quinquefasciatus was similarly prolonged. The tremendous increment in repellency duration observed for the Neo-Innova product, when compared with both current standard and botanical repellent options, represents a milestone in repellent development and supports “once-a-day” applications as a practical strategy for personal protection against mosquitoes.

scholarly journals Natural Anophelin mosquito repellents and phytochemical analysis of ethanol and hexane leaf extracts from four plant species

2021 ◽  
Vol 4 ◽  
Author(s):  
Emad I. Y. Adam ◽  
Yousif O.H.M. Assad ◽  
Marwa M. E. Eltohami ◽  
Nabil H.H. Bashir ◽  
Samira H. Abdelrahman ◽  
...  
Keyword(s):  
Eucalyptus Camaldulensis ◽  
Phytochemical Analysis ◽  
Leaf Extracts ◽  
Protection Time ◽  
Cymbopogon Flexuosus ◽  
Toxic Agents ◽  
Mosquito Repellents ◽  
Ancient Times ◽  
Ethanol Extracts ◽  
Control Application

Currently mosquitoes control is the cornerstone to minimize the rising number of mosquito borne diseases. There is an urgent need looking for alternatives to the current reliance on synthetic insecticides for the vectors control. Application of active toxic agents from plant extracts as an alternative control strategy was available from ancient times. These are non-toxic, easily available at affordable prices, biodegradable and show broad-spectrum target-specific activities against different species of vectors. Natural products with repellency properties are urgently needed. An insect repellent works by masking human scent, and a number of natural and synthetic mosquito repellents were studied. The main aim of this study was to identify the phytochemicals and compare their potentials as mosquito repellents from the ethanol (Et. OH) and hexane (hex) leaf extracts (LEs) of Ocimum basilicum, Coleus forskohlii, Eucalyptus camaldulensis and Cymbopogon flexuosus under laboratory conditions at 50 and 100% concentrations. Phytochemical analysis showed that alkaloids, saponins, flavonoids, terpenes, tannins and terpenoids were present/or absent in the 4 plant-LEs. At 50% concentration of Et. OH extracts, C. forskohlii exhibited higher repellency potential on Anopheles gambiae with protection time of 137.3 min, while O. basilicum, E. camaldulensis and Cy. flexuosus registered protection time of 30.6, 15.3 and 19 min, respectively. At 100% concentration of ethanol- extracts, C. forskohlii caused the highest protection time against the vector with protection time of 182 min. O. basilicum, E. camaldulensis and Cy. flexuosus were equally less potent against the insect, with protection time 42.6, 32.6 and 28 min, respectively. Regarding hex-extract, at 50% concentration of C. forskohlii, the highest repellency potential , with protection time of 174 was registered, while O. basilicum, E. camaldulensis and Cy. flexuosus registered protection times of 44, 18 and 28.6 min, respectively. However, the 100% concentration of Et. OH-extracts of, C. forskohlii and O. basilicum exhibited the highest protection time, with protection times of 228 and 116min, respectively. E. camaldulensis and Cy. flexuosus were less potent, with protection times 28.6 and 54.6 min, respectively. The EOs of C. forskohlii and O. basilicum L EOs proved to have potentials as repellency agents against Anopheles. GC-MS analysis of the extracts identified the compounds of both solvents extracts and the terpens were the major compounds. According to the results, further studies are required, especially on the extracts of basil and coleus since they proved to be effective.

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