Effects of mitomycin-C and 5-fluorouracil on ocular adnexal sebaceous carcinoma cells

2022 ◽  
Author(s):  
Ryan A. Gallo ◽  
Steven H. Lang ◽  
Angela Gomez ◽  
Alfonso L. Sabater ◽  
David T. Tse ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Sebaceous Carcinoma ◽  
Carcinoma Cells

Abstract 2987: Comparison of the anticancer effects of Mitomycin-C and 5-Fluorouracil on novel periocular sebaceous carcinoma cell lines

2021 ◽  
Author(s):  
Steven H. Lang ◽  
Ryan A. Gallo ◽  
Michelle G. Zhang ◽  
David T. Tse ◽  
Daniel Pelaez ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Sebaceous Carcinoma ◽  
Carcinoma Cell Lines ◽  
Anticancer Effects

Ganoderma microsporum immunomodulatory protein induces apoptosis and potentiates mitomycin C-induced apoptosis in urinary bladder urothelial carcinoma cells

2018 ◽  
Vol 119 (6) ◽  
pp. 4592-4606 ◽  
Author(s):  
Sheng-Yuan Huang ◽  
Chih-Cheng Chien ◽  
Ruey-Shyang Hseu ◽  
Victoria Ying Jen Huang ◽  
Shang Ying Chiang ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Mitomycin C ◽  
Carcinoma Cells ◽  
Bladder Urothelial Carcinoma ◽  
Immunomodulatory Protein ◽  
Induced Apoptosis

Hydrostatic pressure enhances mitomycin C induced apoptosis in urothelial carcinoma cells

2014 ◽  
Vol 32 (1) ◽  
pp. 26.e17-26.e24 ◽  
Author(s):  
Shao-Kuan Chen ◽  
Chih-Ang Chung ◽  
Yu-Che Cheng ◽  
Chi-Jung Huang ◽  
Ruoh-Chyu Ruaan ◽  
...  
Keyword(s):  
Hydrostatic Pressure ◽  
Urothelial Carcinoma ◽  
Mitomycin C ◽  
Carcinoma Cells ◽  
Induced Apoptosis

scholarly journals Intraoperative Adjunctive Mitomycin C and Cryotherapy for Recurrent Conjunctival Papillary Sebaceous Carcinoma

2018 ◽  
Vol 9 (1) ◽  
pp. 221-226
Author(s):  
Natsuki Monai ◽  
Reiko Tanabu ◽  
Takayuki Gonome ◽  
Katsunori Yokoi ◽  
Satoshi Urushidate ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Surgical Resection ◽  
Growth Pattern ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Sebaceous Carcinoma ◽  
Adjunctive Treatment ◽  
En Bloc ◽  
Growth Property ◽  
Gland Cells

Purpose: To report a case of recurrent conjunctival papillary sebaceous carcinoma that was successfully treated by a combination of surgical resection, intraoperative topical mitomycin C application, and cryotherapy. Observations: A woman in her 80s developed a yellowish papillary tumor pedunculated from the surface of the upper palpebral tarsal conjunctiva in her left eye. She was histopathologically diagnosed as having sebaceous carcinoma by an excisional biopsy. We performed en bloc resection of the lateral one-third of the posterior lamella including the cutaneous margin of the upper eyelid as well as reconstruction of the defected portion by a switch-flap from the ipsilateral lower eyelid. Histopathologically, because the tumor was restricted to the epithelial region with minimal invasion into the tarsus, we diagnosed the patient to have conjunctival papillary sebaceous carcinoma. Nine months after the surgery, the tumor recurred and was resected and treated by intraoperative mitomycin C. Four months later, the tumor regrew at the resected margins and was treated by resection combined with mitomycin C and cryotherapy. After these combination treatments, the tumor did not recur for at least 1 year postoperatively. Conclusion and Importance: Although sebaceous carcinoma usually originates from the meibomian gland cells or less frequently from the Zeis or Moll gland cells, it rarely occurs from bulbar or palpebral conjunctival cells. Because sebaceous carcinoma sometimes shows a pagetoid growth pattern, it can recur even after en bloc resection with a negative study for tumor cells at the surgical margins. The recurrent sebaceous carcinoma cells showed an intraepithelial growth pattern. Considering this superficial growth property, it may be effective to apply intraoperative mitomycin C and cryotherapy treatment combined with surgical resection to reduce the possibility of recurrence of presumed conjunctival papillary sebaceous carcinoma, although mitomycin C alone seems to be insufficient as an adjunctive treatment.

Molecular comparisons of acquired and native mitomycin C resistance in human colon carcinoma cells

1987 ◽  
Vol 37 (3) ◽  
pp. 267-276 ◽  
Author(s):  
Subhas Chakrabarty ◽  
Michael G. Brattain
Keyword(s):  
Mitomycin C ◽  
Colon Carcinoma ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma

Ocular Sebaceous Carcinoma In Situ With Biphenotypic Differentiation: A Reappraisal of the Alternative Origin of the Tumor

2020 ◽  
Vol 28 (8) ◽  
pp. 888-892
Author(s):  
C. L. Yim ◽  
S. C. Lam ◽  
Hunter Kwok Lai Yuen ◽  
Wah Cheuk
Keyword(s):  
Carcinoma In Situ ◽  
Squamous Carcinoma ◽  
Meibomian Gland ◽  
Sebaceous Carcinoma ◽  
Carcinoma Cells ◽  
Stromal Invasion ◽  
Sebaceous Glands ◽  
Squamous Carcinoma Cells ◽  
Aggressive Tumor

Ocular sebaceous carcinoma is an uncommon, aggressive tumor arising from the Meibomian gland, Zeis gland, or sebaceous glands in the caruncle or eyelashes. We described a rare case of sebaceous carcinoma in situ in a 51-year-old female that was characterized by intraepithelial growth of sebaceous carcinoma cells with no invasive carcinoma in the underlying sebaceous glands. Early stromal invasion was identified that featured 2 distinctive but focally intermixed populations of sebaceous carcinoma cells and squamous carcinoma cells. The 2 populations of cells exhibited their respective distinct immunophenotype but both showed strong overexpression of p53. This case provides evidence to support the hypothesis that some ocular sebaceous carcinoma may arise from intraepithelial pluripotent stem cells.

7- N  -(2-([2-(Gamma-L-glutamylamino)-ethyl]-dithio)-ethyl)-mitomycin C (KW-2149) is more active than mitomycin C on chemonaive and drug-resistant urothelial carcinoma cells

1998 ◽  
Vol 26 (4) ◽  
pp. 243-247 ◽  
Author(s):  
Detlef Rohde ◽  
Gudrun Raffenberg ◽  
Shapur Kaviani ◽  
Johannes Wolff ◽  
Gerhard Jakse
Keyword(s):  
Urothelial Carcinoma ◽  
Mitomycin C ◽  
Carcinoma Cells ◽  
Drug Resistant
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