scholarly journals Perinatal outcomes of in-vitro fertilization (IVF) twins; a population- based cohort study

2022 ◽  
Vol 226 (1) ◽  
pp. S342
Author(s):  
Gali Pariente ◽  
Tamar Wainstock ◽  
Eyal Sheiner
2021 ◽  
Author(s):  
Jessica N Sanders ◽  
Sara E Simonsen ◽  
Christina A Porucznik ◽  
Ahmad O Hammoud ◽  
Ken Smith ◽  
...  

Abstract Background: In vitro fertilization (IVF) births contribute to a considerable proportion of preterm birth (PTB) each year. However, there is no formal surveillance of adverse perinatal outcomes for less invasive fertility treatments. The study objective was to determine the effect of fertility treatment (in vitro fertilization, intrauterine insemination, usually with ovulation drugs (IUI), or ovulation drugs alone) on preterm birth, compared to no treatment in subfertile women.Methods: The Fertility Experiences Study (FES) is a retrospective cohort study conducted at the University of Utah between April 2010 and September 2012. Women with a history of primary subfertility self-reported treatment data via survey and interviews. Participant data were linked to birth certificates and fetal death records to asses for perinatal outcomes, particularly preterm birth.Results: A total 487 birth certificates and 3 fetal death records were linked as first births for study participants who completed questionnaires. Among linked births, 19% had a PTB. After adjustment for maternal age, paternal age, maternal education, annual income, religious affiliation, female or male fertility diagnosis, and duration of subfertility, the odds ratios and 95% confidence intervals (CI) for PTB were 2.17 (CI: 0.99, 4.75) for births conceived using ovulation drugs, 3.17 (CI: 1.4, 7.19) for neonates conceived using IUI and 4.24 (CI: 2.05, 8.77) for neonates conceived by IVF, compared to women with subfertility who used no treatment during the month of conception. A reported diagnosis of female factor infertility increased the adjusted odds of having a PTB 2.99 (CI: 1.5, 5.97). Duration of pregnancy attempt was not independently associated with PTB. In restricting analyses to singleton gestation, odds ratios remained elevated but were not significant for any type of treatment.Conclusion: IVF, IUI, and ovulation drugs were all associated with a higher incidence of preterm birth and low birth weight, predominantly related to multiple gestation births.


PEDIATRICS ◽  
2006 ◽  
Vol 118 (2) ◽  
pp. 475-482 ◽  
Author(s):  
D. Hvidtjorn ◽  
J. Grove ◽  
D. E. Schendel ◽  
M. Vaeth ◽  
E. Ernst ◽  
...  

2014 ◽  
Vol 24 (1-2) ◽  
Author(s):  
Eivind Ystrom ◽  
Ted Reichborn-Kjennerud ◽  
Kristian Tambs ◽  
Per Magnus ◽  
Anne Mari Torgersen ◽  
...  

<p><em>Background:</em> There is a lack of population-based studies on multiple births and maternal mental health. Having a high-risk pregnancy by bearing two or more children is a stressful life event, and the challenges of parenting two or more children probably also lead to a high level of parental stress. There are a few results on multiple births and maternal mental health from studies on in vitro fertilization samples. The only previous cohort study on multiple birth and maternal mental health included a single measure of depressive symptoms at 9 months postpartum. We aim to estimate the relative risk for depression and anxiety after multiple birth in a population-based prospective cohort study while adjusting for factors prior and subsequent to fertilization.</p><p><em>Methods</em>: We used data from 87,807 pregnancies included in the Norwegian Mother and Child Cohort study. Information on multiple birth was retrieved from the Norwegian Medical Birth Registry, and maternal mental health was assessed at 17th and 30th week of gestation and 0.5, 1.5, 3, and 5 years postpartum. There were 1,842 plural births included in the study (i.e. 1,821 twin births and 21 higher order births). We predicted maternal mental health at each time point, subsequently adjusting for 1) factors prior to fertilization (e.g. maternal age and in vitro fertilization); 2) factors during pregnancy (e.g. hypertensive states); 3) factors at delivery (e.g. cesarean section); 4) child-related postnatal complications (e.g. intracranial hemorrhage); and 5) concurrent depression or anxiety after pregnancy.</p><p><em>Results</em>: Adjusted for antecedents of plural birth, mothers expecting a plural birth had a normal risk for anxiety (RR=1.05; 95% CI 0.92-1.20) and depression (RR=1.02; 95% CI 0.89-1.16) at 17th week of gestation. However, plural birth was associated with maternal depression at 1.5, 3, and 5 years postpartum and maternal anxiety at 3 years postpartum. The trend was for the association to increase across time, and mothers of multiplets had a significant higher risk for depression at 5 years (RR=1.77; 95% CI 1.33-2.35). Fully adjusted the RR for depression was 1.51 (95% CI 1.10-2.08). By adjusting depression for concurrent anxiety, and vice versa we found the effect of multiple pregnancy to be specific to depression and not anxiety.</p><p><em>Conclusions:</em> Mothers expecting multiplets have normal mental health during pregnancy. After birth there is an increasing risk for depression up to 5 years of age. Our findings indicate that more is simply more, and mothers of multiplets have need for additional support several years postpartum</p>


2018 ◽  
Vol 51 ◽  
pp. 02008
Author(s):  
Irisa Zile ◽  
Inga Jefremova ◽  
Iveta Gavare

Pregnancies that occur after assisted reproduction procedures constitute high-risk pregnancies. There is a lack of sufficient epidemio-logically based data on this issue in Latvia. The aim of this study was to compare the maternal and perinatal outcomes of multiple pregnancies conceived by in vitro fertilization (IVF) in comparison with spontaneous multiple pregnancies. This retrospective cohort study (2007–2014) analysed data from population-based Medical Birth Register (MBR). There is a statistically significant increase of multiple births from IVF pregnancies – an average 2% per year (p< 0.01). Newborns of IVF multiple births have higher odds of low birth weight (OR = 1.2) and congenital anomalies (OR = 1.6). Maternity characteristics showed that mothers in the IVF group were significantly older than those in the control group (≥35 years) (OR = 2.1) and primipara births (OR = 4.1). Multiple births conceived by IVF have similar outcomes as spontaneously conceived multiples in the perinatal period, although the rates of congenital anomalies after IVF are just slightly higher than in control group.


PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120076 ◽  
Author(s):  
Louise M. Stewart ◽  
C. D’Arcy J. Holman ◽  
James B. Semmens ◽  
David Preen ◽  
Qun Mai ◽  
...  

2022 ◽  
Vol 226 (1) ◽  
pp. S482
Author(s):  
Gali Pariente ◽  
Tamar Wainstock ◽  
Ruslan Sergienko ◽  
Eyal Sheiner

2016 ◽  
Vol 105 (3) ◽  
pp. 590-598.e2 ◽  
Author(s):  
Jorien Seggers ◽  
Martina Pontesilli ◽  
Anita C.J. Ravelli ◽  
Rebecca C. Painter ◽  
Mijna Hadders-Algra ◽  
...  

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