Impact of COVID-19 mandatory lockdown on antenatal metabolic health status and pregnancy outcome

Aims We sought to investigate the association of obesity and metabolic health status with the incidence of clinical hypertrophic cardiomyopathy (HCM) diagnosis in the general population. Our goal was to identify modifiable risk factors to attenuate clinical expression of HCM, enabling management evolution from a mostly passive strategy of risk stratification to a proactive strategy of modifying disease expression. Methods Using nationwide population-based data from the Korean National Health Insurance Service, 28,679,891 people who were free of prevalent HCM and who underwent health examinations between 2009 and 2015 were followed until 31 December 2016. The primary outcome was clinical HCM that was defined as incident diagnosis of HCM during the follow-up, after a blanking period of 12 months. Results Over a median follow-up of 5.2 years, 0.027% ( n = 7851) of the study participants were diagnosed as incident HCM. The incidence rate per 1000 person-years was 0.059. A significant association was found between body mass index (BMI) and the incidence of clinical HCM after multivariate adjustment, with a hazard ratio per 1 kg/m2 increase in BMI of 1.063 (95% confidence interval 1.051–1.075). Metabolically unhealthy participants had a greater incidence of HCM than metabolically healthy participants, regardless of obesity status. The effect of BMI was more pronounced in several subgroups, including participants with no hypertension, those aged less than 65 years and men. Conclusion We found that individuals with obesity and/or metabolic abnormalities had a significantly higher incidence of clinical HCM diagnosis than their counterparts. Efforts to manage obesity and metabolic abnormalities may be important in modifying clinical expression of HCM.

Download Full-text

Incidence of Prostate Cancer according to Metabolic Health Status: a Nationwide Cohort Study

Journal of Korean Medical Science ◽

10.3346/jkms.2019.34.e49 ◽

2019 ◽

Vol 34 (6) ◽

Cited By ~ 3

Author(s):

Jong Wook Kim ◽

Sun Tae Ahn ◽

Mi Mi Oh ◽

Du Geon Moon ◽

Kyungdo Han ◽

...

Keyword(s):

Prostate Cancer ◽

Cohort Study ◽

Health Status ◽

Metabolic Health

Download Full-text

Effects of T's and Blues Abuse on Pregnancy Outcome and Infant Health Status

American Journal of Perinatology ◽

10.1055/s-2007-999523 ◽

1990 ◽

Vol 7 (04) ◽

pp. 359-362 ◽

Cited By ~ 6

Author(s):

Bertis Little ◽

Laura Snell ◽

Jeffrey Breckenridge ◽

Kraig Knoll ◽

Victor Klein ◽

...

Keyword(s):

Health Status ◽

Pregnancy Outcome ◽

Infant Health

Download Full-text

Transitions in metabolic health status over time and risk of heart failure: a prospective study

Diabetes & Metabolism ◽

10.1016/j.diabet.2021.101266 ◽

2021 ◽

pp. 101266

Author(s):

Jianing Bi ◽

Lulu Song ◽

Lulin Wang ◽

Binbin Su ◽

Mingyang Wu ◽

...

Keyword(s):

Heart Failure ◽

Health Status ◽

Prospective Study ◽

Metabolic Health ◽

A Prospective Study ◽

Over Time

Download Full-text

Does metabolic health in overweight and obesity persist? – Individual variation and cardiovascular mortality over two decades

Acta Endocrinologica ◽

10.1530/eje-16-0095 ◽

2016 ◽

Vol 175 (2) ◽

pp. 133-143 ◽

Cited By ~ 13

Author(s):

Akaal Kaur ◽

Desmond G Johnston ◽

Ian F Godsland

Keyword(s):

Insulin Resistance ◽

Cardiovascular Risk ◽

Health Status ◽

Cardiovascular Mortality ◽

Normal Weight ◽

Metabolic Health ◽

Overweight And Obesity ◽

Cross Sectional ◽

Increased Risk ◽

Metabolically Healthy

Objective Overweight and obese individuals may be metabolically healthy, but attention needs to be given to long-term persistence of this trait and any associated variation in cardiovascular risk. Design Cross-sectional and longitudinal variation in metabolic health and associated cardiovascular mortality were analysed in 1099 white European-origin normal-weight and overweight or obese males followed for 20years. Methods Definitions of metabolic health were based on LDL and HDL cholesterol, triglycerides, blood pressure, fasting glucose and cardiovascular risk. Insulin resistance (e.g. HOMA-IR) and sub-clinical inflammation (ESR and white blood cell count) were explored. Cardiovascular mortality risks and persistence of metabolic health status were evaluated. Results There were 87 cardiovascular deaths. Insulin resistance was increased in metabolically healthy overweight or obese participants (median HOMA-IR 2.63, 95% CI: 1.79–3.65, P<0.001) relative to normal-weight participants (median HOMA-IR 1.67, 95% CI: 1.08–2.67, P<0.001) as was sub-clinical inflammation but metabolically healthy overweight or obese individuals were not at increased risk of cardiovascular mortality compared with the metabolically healthy normal-weight individuals (hazard ratio 1.13, 95% CI: 0.34–3.72, P=0.8). The proportions of initially metabolically healthy overweight or obese who remained metabolically healthy for visits 2, 3 and 4 were 54, 48 and 39% respectively, and for initially normal-weight individuals, 68, 51 and 41%. A lower proportion of metabolically healthy overweight or obese individuals remained metabolically healthy at visit 2 compared with normal-weight individuals (P=0.007), but proportions converged thereafter. Conclusions Despite being insulin resistant and having greater sub-clinical inflammation, and despite instability in metabolic health status, metabolically healthy overweight or obese individuals were at no greater risk of cardiovascular mortality than their normal-weight equivalents.

Download Full-text