The computational analysis for micro channel flow in a branched network was investigated by three dimensional CFD approach. The effect of the change of Inlet Plenum (IP) size at a constant Aspect Ratio (AR) of the outermost channel on pressure drop in a fractal branched micro channel was performed. The properties are compared along a particular path and it was observed that the pressure drop along a bifurcated path has considerably less effect when compared to that of the outer most straight branched channel for a constant aspect ratio model. Pressure does not change significantly if we change the IP radius even when all other parameters are constant. Velocity in the inner channel after a straight run has reduced significantly even for same AR and Reynolds Number (Re). This leads to the conclusion that the IP size affects the velocity after the bifurcation.