Detection of additional occult malignancy though profiling of ctDNA in late-stage cancer patients

Author(s):  
M. Aldea ◽  
L. Cerbone ◽  
A. Bayle ◽  
C. Parisi ◽  
C. Sarkozy ◽  
...  
2006 ◽  
Vol 31 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Sean Ransom ◽  
William P. Sacco ◽  
Michael A. Weitzner ◽  
Lora M. Azzarello ◽  
Susan C. McMillan

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 232 ◽  
Author(s):  
Martin L. Ashdown ◽  
Andrew P. Robinson ◽  
Steven L. Yatomi-Clarke ◽  
M. Luisa Ashdown ◽  
Andrew Allison ◽  
...  

Complete response (CR) rates reported for cytotoxic chemotherapy for late-stage cancer patients are generally low, with few exceptions, regardless of the solid cancer type or drug regimen. We investigated CR rates reported in the literature for clinical trials using chemotherapy alone, across a wide range of tumour types and chemotherapeutic regimens, to determine an overall CR rate for late-stage cancers. A total of 141 reports were located using the PubMed database. A meta-analysis was performed of reported CR from 68 chemotherapy trials (total 2732 patients) using standard agents across late-stage solid cancers—a binomial model with random effects was adopted. Mean CR rates were compared for different cancer types, and for chemotherapeutic agents with different mechanisms of action, using a logistic regression. Our results showed that the CR rates for chemotherapy treatment of late-stage cancer were generally low at 7.4%, regardless of the cancer type or drug regimen used. We found no evidence that CR rates differed between different chemotherapy drug types, but amongst different cancer types small CR differences were evident, although none exceeded a mean CR rate of 11%. This remarkable concordance of CR rates regardless of cancer or therapy type remains currently unexplained, and motivates further investigation.


2019 ◽  
Vol 42 (8) ◽  
pp. 675-681
Author(s):  
Jinhai Huo ◽  
Jiang Bian ◽  
Zhigang Xie ◽  
Young-Rock Hong ◽  
Diana J. Wilkie ◽  
...  

2017 ◽  
Vol 35 (31_suppl) ◽  
pp. 188-188
Author(s):  
Alyson B. Moadel ◽  
Fernando J. Camacho ◽  
Nicolas Schlecht

188 Background: Socioeconomic disparities in psychosocial outcomes among cancer patients have been documented. High interest in peer support and mind-body therapies across diverse populations presents an opportunity for enhancing end-of-life care in the underserved setting. We present the results of a psychosocial needs assessment, and the findings from a feasibility trial in which peer navigators (PN; cancer survivor volunteers) were taught to deliver Loving Kindness (LK) Meditation in preparation for their role as end-of-life “Doulas”. Methods: (1) A survey of psychosocial symptoms and needs was administered to a convenience sample of 56 stage IV patients from an NCI-designated cancer center in Bronx, NY. Patients were female (75%), African American (43%), Hispanic (45%), and 56 M years old. (2) A feasibility trial randomly assigned 9 patients to receive LK meditation delivered by 1 of 4 trained PNs or a professional meditation instructor. The trial was rated on 8 measures of feasibility as set forth by Bowen et al 2009. Results: Patients reported high sadness (66%), anxiety (54%), anger (41%), and spiritual distress (18%) with 70% endorsing an interest in mind-body therapies “such as meditation”, and 46% an interest in a PN. In the LK meditation feasibility trial, patients reported improved positive affect scores by a clinically significant margin of 13%, with equivalent impact and satisfaction for PN relative to professional instructor. Conclusions: Inner city late stage cancer patients endorse high distress, and high interest in peer support and mind-body interventions. Feasibility testing demonstrates that LK meditation is responsive to patient preference and demonstrates preliminary efficaciousness. Findings suggest that Doula-delivered meditation for underserved patients presents a unique resource in the palliative care setting.


2012 ◽  
Vol 65 (10) ◽  
pp. 1350-1356 ◽  
Author(s):  
Helio R.N. Alves ◽  
Luis C. Ishida ◽  
Luis H. Ishida ◽  
Julio M. Besteiro ◽  
Rolf Gemperli ◽  
...  

2009 ◽  
Vol 18 (11) ◽  
pp. 1429-1436 ◽  
Author(s):  
Linda E. Francis ◽  
Julie Worthington ◽  
Georgios Kypriotakis ◽  
Julia H. Rose

1993 ◽  
Vol 16 (4) ◽  
pp. 310???320 ◽  
Author(s):  
Delia K. Roberts ◽  
Sally E. Thorne ◽  
Christine Pearson

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