Efficacy of ASP2151, a helicase–primase inhibitor, against thymidine kinase-deficient herpes simplex virus type 2 infection in vitro and in vivo

2012 ◽  
Vol 93 (2) ◽  
pp. 301-304 ◽  
Author(s):  
Takehiro Himaki ◽  
Yumi Masui ◽  
Koji Chono ◽  
Tohru Daikoku ◽  
Masaya Takemoto ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

scholarly journals Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo

Viruses ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 119 ◽  
Author(s):  
Wenwen Dai ◽  
Yu Wu ◽  
Jinpeng Bi ◽  
Shuai Wang ◽  
Fang Li ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Antiviral Effects ◽  
Simplex Virus

scholarly journals Activity of compounds containing echinochrome A against herpes simplex virus type 2 in vitro and in vivo

2019 ◽  
pp. 56-64 ◽  
Author(s):  
N. V. Krylova ◽  
I. A. Leneva ◽  
S. A. Fedoreev ◽  
L. K. Ebralidze ◽  
N. P. Mishchenko ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Antioxidant Properties ◽  
Echinochrome A ◽  
Simplex Virus

The aim of the work was to study the activity of echinochrome A, a naphthoquinoid pigment from sea urchins, and its antioxidant composition against herpes simplex virus type 2 (HSV-2) in vitro and in vivo.Materials and methods. Strain HSV-2 (G ATCC VR-734) was grown in Vero cells. The cytotoxic and anti-HSV-2 activity of the compounds was assessed in vitro by the cell viability and by cytopathic effect inhibition of virus using MTT test. The efficacy of compounds in mice model of vaginitis caused by HSV-2 was determined by the average lifetime, body weight and viral load changes.Results and discussion. The antioxidant composition (echinochrome A, ascorbic acid and α-tocopherol (5:5:1)), showed a higher antiviral efficacy than echinochrome A alone. Oral administration of the antioxidant composition protected 90% of the infected mice against death and reduced vaginal viral loads. The antiviral activity of echinochrome A and the antioxidant composition is probably due to the virus-inhibiting activity of the compounds and their antioxidant properties.Conclusion. The results obtained allow considering the tested compounds as promising agents with antiviral properties.

scholarly journals Suppression of human papillomavirus gene expression in vitro and in vivo by herpes simplex virus type 2 infection

Virology ◽  
2003 ◽  
Vol 314 (1) ◽  
pp. 147-160 ◽  
Author(s):  
L Fang ◽  
M.G Ward ◽  
P.A Welsh ◽  
L.R Budgeon ◽  
E.B Neely ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Papillomavirus ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

The effect of prostaglandins on the multiplication and cell-to-cell spread of herpes simplex virus type 2 in vitro

1982 ◽  
Vol 144 (3) ◽  
pp. 346-349 ◽  
Author(s):  
David A. Baker ◽  
Joanne Thomas ◽  
Judy Epstein ◽  
Dominic Possilico ◽  
Martin L. Stone
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus ◽  
Cell Spread
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