scholarly journals Five novel triterpenoid saponins from Hovenia dulcis and their Nrf2 inhibitory activities

2021 ◽  
pp. 103292
Author(s):  
Wanna Cai ◽  
Shengmei Xu ◽  
Ting Ma ◽  
Xiaoqi Zhang ◽  
Bo Liu ◽  
...  
Keyword(s):  
Triterpenoid Saponins ◽  
Inhibitory Activities ◽  
Hovenia Dulcis

Triterpenoid saponins from Clematis chinensis and their inhibitory activities on NO production

2017 ◽  
Vol 21 ◽  
pp. 206-210 ◽  
Author(s):  
Qiang Fu ◽  
Lu Qiu ◽  
Hai-Mei Yuan ◽  
Yu-Feng Du ◽  
Xiao-Ling Cheng ◽  
...  
Keyword(s):  
No Production ◽  
Triterpenoid Saponins ◽  
Inhibitory Activities

Four new triterpenoid saponins isolated from Schefflera kwangsiensis and their inhibitory activities against FBPase1

2016 ◽  
Vol 15 ◽  
pp. 204-209 ◽  
Author(s):  
Yan Wang ◽  
Yan-Fei Liu ◽  
Chun-Lei Zhang ◽  
Dong Liang ◽  
Huan Luo ◽  
...  
Keyword(s):  
Triterpenoid Saponins ◽  
Inhibitory Activities

scholarly journals Triterpenoid Saponins from the Cultivar “Green Elf” of Pittosporum tenuifolium

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6805
Author(s):  
David Pertuit ◽  
Anne-Claire Mitaine-Offer ◽  
Tomofumi Miyamoto ◽  
Chiaki Tanaka ◽  
Christine Belloir ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
New Zealand ◽  
Ethanolic Extract ◽  
2D Nmr ◽  
Sweet Taste ◽  
Spectroscopic Methods ◽  
Triterpenoid Saponins ◽  
Crude Saponin ◽  
Aqueous Ethanolic Extract ◽  
Inhibitory Activities

Four oleanane-type glycosides were isolated from a horticultural cultivar “Green Elf” of the endemic Pittosporum tenuifolium (Pittosporaceae) from New Zealand: three acylated barringtogenol C glycosides from the leaves, with two previously undescribed 3-O-β-d-glucopyranosyl-(1→2)-[α-l-arabinopyranosyl-(1→3)]-β-d-glucuronopyranosyl-21-O-angeloyl-28-O-acetylbarringtogenol C, 3-O-β-d-galactopyranosyl-(1→2)-[α-l-arabinopyranosyl-(1→3)]-β-d-glucuronopyranosyl-21-O-angeloyl-28-O-acetylbarringtogenol C, and the known 3-O-β-d-glucopyranosyl-(1→2)-[α-l-arabinopyranosyl-(1→3)]-β-d-glucuronopyranosyl-21-O-angeloyl-28-O-acetylbarringtogenol C (Eryngioside L). From the roots, the known 3-O-β-d-glucopyranosyl-(1→2)-β-d-galactopyranosyl-(1→2)-β-d-glucuronopyranosyloleanolic acid (Sandrosaponin X) was identified. Their structures were elucidated by spectroscopic methods including 1D- and 2D-NMR experiments and mass spectrometry (ESI-MS). According to their structural similarities with gymnemic acids, the inhibitory activities on the sweet taste TAS1R2/TAS1R3 receptor of an aqueous ethanolic extract of the leaves and roots, a crude saponin mixture, 3-O-β-d-glucopyranosyl-(1→2)-[α-l-arabinopyranosyl-(1→3)]-β-d-glucuronopyranosyl-21-O-angeloyl-28-O-acetylbarringtogenol C, and Eryngioside L were evaluated.

scholarly journals Six New Triterpenoid Saponins from the Leaves of Ilex oblonga and Their Inhibitory Activities against TMV Replication

2007 ◽  
Vol 55 (3) ◽  
pp. 422-427 ◽  
Author(s):  
Zu-Jian Wu ◽  
Ming-An Ouyang ◽  
Cong-Zhou Wang ◽  
Zheng-Kun Zhang
Keyword(s):  
Triterpenoid Saponins ◽  
Inhibitory Activities

scholarly journals Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum

Molecules ◽  
2019 ◽  
Vol 24 (12) ◽  
pp. 2206 ◽  
Author(s):  
Dongdong Zhang ◽  
Yao Fu ◽  
Jun Yang ◽  
Xiao-Nian Li ◽  
Myint Myint San ◽  
...  
Keyword(s):  
Trichophyton Rubrum ◽  
Microsporum Gypseum ◽  
Dioic Acid ◽  
Triterpenoid Saponins ◽  
Methyl Group ◽  
Antifungal Activities ◽  
One Dimensional ◽  
Inhibitory Activities ◽  
Whole Plants ◽  
New Compounds

Four new triterpenoids, 3β,12β,16β,21β,22-pentahydroxyhopane (1), 12β,16β,21β,22-tetrahydroxyhopan-3-one (2), 3-oxo-olean-12-ene-28,30-dioic acid (3), and 3β-hydroxyoleana-11,13(18)-diene-28,30-dioic acid 30-methyl ester (4); 21 new triterpenoid saponins, glinusopposides A–U (5–25); and 12 known compounds (26–37) were isolated from the whole plants of Glinus oppositifolius. The structures of the new compounds were elucidated based on the analysis of one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. All compounds from the plants were measured for antifungal activities against Microsporum gypseum and Trichophyton rubrum. Glinusopposide B (6), glinusopposide Q (21), glinusopposide T (24), and glinusopposide U (25) showed strong inhibitory activities against M. gypseum (MIC50 7.1, 6.7, 6.8, and 11.1 μM, respectively) and T. rubrum (MIC50 14.3, 13.4, 11.9, and 13.0 μM, respectively). For those active compounds with an oleanane skeleton, glycosylation (21–26) or oxidation (3) of 3-OH was helpful in increasing the activity; replacement of the 30-methyl group (29) by a carboxymethyl group (26) enhanced the activity; the presence of 11,13(18) double bonds (20) decreased the activity.

scholarly journals New Dammarane-Type Triterpenoid Saponins from Panax notoginseng Leaves and Their Nitric Oxide Inhibitory Activities

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 139 ◽  
Author(s):  
Fan Sun ◽  
Jingya Ruan ◽  
Wei Zhao ◽  
Ying Zhang ◽  
Guilin Xiang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Spectral Analysis ◽  
Chemical Reactions ◽  
Panax Notoginseng ◽  
Pathological Process ◽  
Triterpenoid Saponins ◽  
Inflammatory Drugs ◽  
Inhibitory Activities ◽  
Anti Inflammatory ◽  
Dose Dependent

Inflammation is a very common and important pathological process that can cause many diseases. The discovery of anti-inflammatory drugs and the treatment of inflammation are particularly essential. Dammarane-type triterpenoid saponins (PNS) were demonstrated to show anti-inflammatory effects in the leaves of Panax notoginseng. Chromatographies and spectral analysis methods were combined to isolate and identify PNS. Moreover, the nitric oxide (NO) inhibitory activities of all compounds were examined in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. As a result, eleven new dammarane-type triterpenoid saponins, notoginsenosides NL-A1–NL-A4 (1–4), NL-B1–NL-B3 (5–7), NL-C1–NL-C3 (8–10), and NL-D (11) were isolated, and their structures were identified by using various spectrometric techniques and chemical reactions. Among them, compounds 4 and 11 were characterized by the malonyl substitution at 3-position. The 3-malonyl substituted dammarane-type terpennoids were first obtained from natural products. In addition, compounds 1, 2, 5, 6, and 8–10 were found to play an important role in suppressing NO levels at 50 μM, without cytotoxicity. All inhibitory activities were found to be dose-dependent.

Five New Oleanane Triterpenoid Saponins from the Aerial Parts ofElsholtzia bodinieri

2016 ◽  
pp. n/a-n/a
Author(s):  
Jin-Dong Zhong ◽  
Xue-Wei Zhao ◽  
Hong-Mei Li ◽  
Ling-Huan Gao ◽  
Rong-Tao Li
Keyword(s):  
Triterpenoid Saponins ◽  
Aerial Parts ◽  
Oleanane Triterpenoid

Triterpenoid saponins from the cytotoxic root extract of Sideroxylon foetidissimum, an endemic Yucatecan medicinal plant

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
A Sánchez-Medina ◽  
PC Stevenson ◽  
S Habtemariam ◽  
LM Peña-Rodríguez ◽  
O Corcoran ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Root Extract ◽  
Triterpenoid Saponins
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