scholarly journals Fragility Index as a Measure of Randomized Clinical Trial Quality in Adult Reconstruction: A Systematic Review

2021 ◽  
Vol 11 ◽  
pp. 239-251
Author(s):  
Carl L. Herndon ◽  
Kyle L. McCormick ◽  
Anastasia Gazgalis ◽  
Elise C. Bixby ◽  
Matthew M. Levitsky ◽  
...  
2012 ◽  
Vol 1 (1) ◽  
Author(s):  
Jennifer M Tetzlaff ◽  
An-Wen Chan ◽  
Jessica Kitchen ◽  
Margaret Sampson ◽  
Andrea C Tricco ◽  
...  

2019 ◽  
Vol 114 (1) ◽  
pp. S2-S2
Author(s):  
Elfaituri Muhammed ◽  
Fransawy Alkomos Mina ◽  
Kalo Ammar ◽  
Hue Nguyen Thi Linh ◽  
Alshareef Abdulmoate ◽  
...  

2020 ◽  
Vol 3 (8) ◽  
pp. e2012469
Author(s):  
Muhammad Shahzeb Khan ◽  
Gregg C. Fonarow ◽  
Tim Friede ◽  
Noman Lateef ◽  
Safi U. Khan ◽  
...  

2020 ◽  
Vol 14 (28) ◽  
pp. 91-96
Author(s):  
Mirna Clemente ◽  
Astrid Wiens ◽  
Marilis Dallarmi Miguel ◽  
Karina Bettega Felipe ◽  
Erick Fifres Clemente ◽  
...  

2017 ◽  
Vol 43 (5) ◽  
pp. E18 ◽  
Author(s):  
Vyshak Chandra ◽  
Andrew K. Rock ◽  
Charles Opalak ◽  
Joel M. Stary ◽  
Adam P. Sima ◽  
...  

OBJECTIVEThe majority of neurosurgeons administer antiepileptic drugs (AEDs) prophylactically for supratentorial tumor resection without clear evidence to support this practice. The putative benefit of perioperative seizure prophylaxis must be weighed against the risks of adverse effects and drug interactions in patients without a history of seizures. Consequently, the authors conducted a systematic review of prospective randomized controlled trials (RCTs) that have evaluated the efficacy of perioperative seizure prophylaxis among patients without a history of seizures.METHODSFive databases (PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, CINAHL/Academic Search Complete, Web of Science, and ScienceDirect) were searched for RCTs published before May 2017 and investigating perioperative seizure prophylaxis in brain tumor resection. Of the 496 unique research articles identified, 4 were selected for inclusion in this review.RESULTSThis systematic review revealed a weighted average seizure rate of 10.65% for the control groups. There was no significant difference in seizure rates among the groups that received seizure prophylaxis and those that did not. Further, this expected incidence of new-onset postoperative seizures would require a total of 1258 patients to enroll in a RCT, as determined by a Farrington-Manning noninferiority test performed at the 0.05 level using a noninferiority difference of 5%.CONCLUSIONSAccording to a systematic review of major RCTs, the administration of prophylactic AEDs after brain tumor resection shows no significant reduction in the incidence of seizures compared with that in controls. A large multicenter randomized clinical trial would be required to assess whether perioperative seizure prophylaxis provides benefit for patients undergoing brain tumor resection.


2021 ◽  
Author(s):  
Timotius Ivan Hariyanto ◽  
Devina Adella Halim ◽  
Jane Rosalind ◽  
Catherine Gunawan ◽  
Andree Kurniawan

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S382
Author(s):  
Muhammed Khaled Elfaituri ◽  
Mina Fransawy Alkomos ◽  
Tran Thai Huu Loc ◽  
Nguyen Thi Linh Hue ◽  
Abdulmoate Alhadi Alshareef ◽  
...  

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