scholarly journals Association Between Simultaneous Bilateral Total Hip Arthroplasty Without Any Anticoagulant or Antiplatelet Therapy and Deep Venous Thrombosis: A Cohort Study

2022 ◽  
Vol 13 ◽  
pp. 62-68
Author(s):  
Masaki Hatano ◽  
Masaki Nakamura ◽  
Hiroyuki Ohbe ◽  
Izuru Kitajima ◽  
Kazuya Isawa ◽  
...  
2020 ◽  
Author(s):  
Akira Hashimoto ◽  
Motoki Sonohata ◽  
Hirohito Hirata ◽  
Shunsuke Kawano ◽  
Shuichi Eto ◽  
...  

Abstract Background: Of late, periarticular analgesic injection (PAI) has become a common alternative treatment for pain following total hip arthroplasty (THA). However, the systemic effects of PAI containing corticosteroids in patients subjected to THA have not been investigated. This study evaluated the analgesic efficacy and systemic effects of PAI containing a corticosteroid in patients subjected to THA. Methods: This single-center, retrospective cohort study enrolled patients undergoing unilateral, primary THA. A total of 197 patients (200 hips) were included in the final analyses, with 87 hips in the PAI group and 113 hips in the control group. Numeric Rating Scale (NRS) and laboratory data were assessed preoperatively and on postoperative days (POD) 1 and 7. Pearson’s correlation coefficients were obtained to assess the correlations between the D-dimer level on POD 7 and each outcome measure on POD 1. Results: The postoperative white blood cell count (WBC) was significantly higher in the PAI group than in the control group. Postoperative NRS, creatine phosphokinase (CK), and C-reactive protein (CRP) levels were significantly lower in the PAI group. D-dimer levels were significantly lower in the PAI group on POD 7. Postoperative aspartate transaminase (AST), alanine aminotransferase, blood urea nitrogen, and creatinine levels were within reference ranges. D-dimer levels on POD 7 showed a significant negative correlation with WBC on POD 1 (r=-0.4652) and a significant positive correlation with the NRS score and AST, CK, CRP, and D-dimer levels on POD 1 (r=0.1558, 0.2353, 0.2718, 0.3545, and 0.3359, respectively).Conclusions: PAI containing a corticosteroid may be an effective treatment for pain and inflammation after THA, and it does not seem to cause drug-induced liver or kidney injury. Moreover, corticosteroid PAI can reduce D-dimer levels, which are associated with deep venous thrombosis. Early ambulation may prevent the elevation of postoperative D-dimer levels, and PAI containing a corticosteroid may accelerate early ambulation and reduce the risk of deep venous thrombosis.


2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Akira Hashimoto ◽  
Motoki Sonohata ◽  
Hirohito Hirata ◽  
Shunsuke Kawano ◽  
Shuichi Eto ◽  
...  

Abstract Background Of late, periarticular analgesic injection (PAI) has become a common alternative treatment for pain following total hip arthroplasty (THA). However, the systemic effects of PAI containing corticosteroids in patients subjected to THA have not been investigated. This study evaluated the analgesic efficacy and systemic effects of PAI containing a corticosteroid in patients subjected to THA. Methods This single-center, retrospective cohort study enrolled patients undergoing unilateral, primary THA. A total of 197 patients (200 hips) were included in the final analyses, with 87 hips in the PAI group and 113 hips in the control group. Numeric Rating Scale (NRS) and laboratory data were assessed preoperatively and on postoperative days (POD) 1 and 7. Pearson’s correlation coefficients were obtained to assess the correlations between the D-dimer level on POD 7 and each outcome measure on POD 1. Results The postoperative white blood cell count (WBC) was significantly higher in the PAI group than in the control group. Postoperative NRS, creatine phosphokinase (CK), and C-reactive protein (CRP) levels were significantly lower in the PAI group. D-dimer levels were significantly lower in the PAI group on POD 7. Postoperative aspartate transaminase (AST), alanine aminotransferase, blood urea nitrogen, and creatinine levels were within reference ranges. D-dimer levels on POD 7 showed a significant negative correlation with WBC on POD 1 (r=-0.4652) and a significant positive correlation with the NRS score and AST, CK, CRP, and D-dimer levels on POD 1 (r = 0.1558, 0.2353, 0.2718, 0.3545, and 0.3359, respectively). Conclusions PAI containing a corticosteroid may be an effective treatment for pain and inflammation after THA, and it does not seem to cause drug-induced liver or kidney injury. Moreover, corticosteroid PAI can may accelerate early ambulation, which prevents the elevation of postoperative D-dimer levels, and may reduce the risk of deep venous thrombosis.


1994 ◽  
Vol &NA; (299) ◽  
pp. 203???208 ◽  
Author(s):  
ARTHUR TROWBRIDGE ◽  
CLIFFORD KENT BOESE ◽  
BERNADETTE WOODRUFF ◽  
HANES H. BRINDLEY ◽  
WALLACE E. LOWRY ◽  
...  

1999 ◽  
Vol 361 ◽  
pp. 123-130 ◽  
Author(s):  
Knute O. Buehler ◽  
Darryl D. D'Lima ◽  
William J. Petersilge ◽  
Clifford W. Colwell ◽  
Richard H. Walker

2011 ◽  
Vol 21 (6) ◽  
pp. 684-687 ◽  
Author(s):  
Motomi Ishibe ◽  
Satoru Kariya

We conducted a retrospective study of the occurrence of deep venous thrombosis (DVT) following mini-posterior total hip arthroplasty (THA) in Japanese patients. From May 2004 to December 2009 mini-posterior THA was performed on 1659 cases, of whom 603 cases didn't receive anticoagulants (Group 1), 547 cases received 2.5 mg percutaneous injection of fondaparinux (a factor Xa inhibitor) daily for 7 days starting the day after surgery (Group 2), and 509 cases received 2000IU percutaneous injection of enoxaparin (low-molecular-weight heparin) twice daily for 7 days starting the day after surgery (Group 3). The baseline characteristics were very similar in each group. All patients started walking the day after surgery, were advised to wear graduated compression stockings for six weeks after the operation, and used a foot pump for 3 hours a day postoperatively for several days. A week after surgery Duplex ultrasound with colour-flow Doppler imaging of the lower extremities was performed. The occurrence of DVT was significantly different between Groups 1, 2, and 3 (p<0.001): 57 cases (9.5%), 4 cases (0.7%), and 0 cases (0%), respectively. No patients of any group had clinically detected pulmonary emboli. In this study we showed that adding anticoagulants with foot pumps further reduced the incidence of DVT, which seldom occurs following less invasive mini-posterior THA combined with early mobilisation, foot pumps, and anticoagulants.


1994 ◽  
Vol 9 (6) ◽  
pp. 611-616 ◽  
Author(s):  
Peter G. Dalldorf ◽  
Frederick M. Perkins ◽  
Saara Totterman ◽  
Vincent D. Pellegrini

2001 ◽  
Vol 30 (11) ◽  
pp. 890-896 ◽  
Author(s):  
F. Böttner ◽  
T. P. Sculco ◽  
N. E. Sharrock ◽  
G. H. Westrich ◽  
J. Steinbeck

2015 ◽  
Vol 20 (6) ◽  
pp. 1142-1147 ◽  
Author(s):  
Hiroshi Watanabe ◽  
Kenji Takahashi ◽  
Kenji Takenouchi ◽  
Akiko Sato ◽  
Hidemi Kawaji ◽  
...  

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