Autologous platelet-rich plasma for non-ischemic diabetic foot ulcers

Author(s):  
Khan Sharun ◽  
Abhijit M. Pawde
Biomedicine ◽  
2021 ◽  
Vol 41 (4) ◽  
pp. 849-854
Author(s):  
Swathika Rajendran ◽  
Manuneethimaran Thiyagarajan ◽  
Balaji Singh K. ◽  
Nitesh Navrathan

Introduction and Aim: This study has been undertaken to evaluate efficacy of platelet rich plasma (PRP) dressing that is recently introduced with conventional dressing. We have tried to compare PRP dressing with conventional normal dressing in healing the wound.   Materials and Methods: We conducted this study in 120 patients of chronic non healing diabetic foot ulcers who were treated over the period of three years. Number of cases (60 each) were studied for efficacy of applying autologous platelet rich plasma versus normal dressing for chronic non healing diabetic foot ulcers. At every week follow up, the ulcer was examined for granulation tissue, area and volume which was calculated using Vernier calipers and marked on a graph paper and photographs were taken. Wound healing was compared between PRP and normal dressing.   Results: The incidence of male susceptibility was more (70%) than females (30%) in diabetic foot. Average rate of healing per week was found to be significantly better among the PRP group than normal dressing group. The ulcer showed significant reduction in size among the PRP group in comparison to the normal dressing group with a significant P value (0.001).   Conclusion: In this study application of platelet rich plasma into chronic non-healing diabetic foot ulcers in comparison with conventional dressing has shown a significant reduction in the size of the ulcer, hospital stay and cost for the patient.


2017 ◽  
Vol 26 (12) ◽  
pp. 784-787 ◽  
Author(s):  
V. Babaei ◽  
H. Afradi ◽  
H.Z. Gohardani ◽  
F. Nasseri ◽  
M. Azarafza ◽  
...  

2004 ◽  
Vol 14 (6) ◽  
pp. 395-396 ◽  
Author(s):  
G. Saldalamacchia ◽  
E. Lapice ◽  
V. Cuomo ◽  
E. De Feo ◽  
E. D'Agostino ◽  
...  

2018 ◽  
Vol 5 (10) ◽  
pp. 3210 ◽  
Author(s):  
Nithyaraj Prakasam ◽  
Prabakar M.S. ◽  
Reshma S. ◽  
Loganathan K. ◽  
Senguttuvan K.

Background: Diabetic foot ulcers continue to pose significant global issue despite the advances made in the management of diabetes. It causes major foot complications if they are not addressed properly. It needs multidisciplinary approach for its care. While several advancements has taken place in wound care management, platelet rich plasma and stem cell therapy promises to offer a new hope in its management, aiding in cellular and tissue regeneration. The purpose of the present study was to compare Platelet-Rich Plasma versus conventional dressing in the management of diabetic foot ulcers.Methods: This prospective study was focused on 20 diabetic foot ulcers, carried out in a surgical unit of ACS Medical College and Hospital, Chennai, Tamil Nadu, from January 2018 to June 2018. Patients were divided into two groups; Group A received conventional ordinary dressing (N=10, 50%) and Group B received PRP dressing (N = 10, 50%). The mean follow-up period was 8 weeks.Results: The estimated time of wound healing was 8 weeks and healing was found to be more effective for patients in group B compared to patients in group A; the PRP group was found to be more effective in wound healing with fewer complications, less infection, exudates and pain.Conclusions: There have been considerable advances in the use of PRP in therapeutic processes in recent years in tissue regeneration therapy. PRP is a powerful tool for the treatment of chronic wounds and very promising for diabetic foot wounds; PRP enables healing, and reduces amputation rates, infection and exudates.


2011 ◽  
Vol 8 (3) ◽  
pp. 307-312 ◽  
Author(s):  
Hany Saad Setta ◽  
Ahmed Elshahat ◽  
Khalid Elsherbiny ◽  
Karim Massoud ◽  
Ikram Safe

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