Brain changes associated with impaired attention function in chronic pain

2021 ◽  
Vol 154 ◽  
pp. 105806
Author(s):  
Atsuo Yoshino ◽  
Naofumi Otsuru ◽  
Go Okada ◽  
Keisuke Tanaka ◽  
Satoshi Yokoyama ◽  
...  
PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247880
Author(s):  
Jannike H-L Ausland ◽  
Bo Engdahl ◽  
Bente Oftedal ◽  
Ólöf A. Steingrímsdóttir ◽  
Christopher S. Nielsen ◽  
...  

Tinnitus and pain have many similarities. Both are subjective sensations that may turn chronic, they are often accompanied by hypersensitivity in their respective sensory system, and overlapping brain changes have been observed. Since no population study has examined the empirical association between chronic pain and tinnitus, the present study aimed to explore the relationship in a general adult population. We used data from the seventh survey of the Tromsø Study (2015–2016). Participants (aged ≥40) responded to questions about pain and tinnitus. Using multiple logistic regression, we analysed the adjusted relationship between chronic pain and tinnitus in the full sample (n = 19,039), using several tinnitus definitions ranging from tinnitus >5 minutes within the past 12 months (broadest definition) to at least weekly and highly bothersome tinnitus (strictest definition). We also analysed relationships between number of body regions with pain, pain intensity and bothering, and tinnitus >5 minutes, among participants with chronic pain (n = 11,589). We found an association between chronic pain and tinnitus that was present irrespective of tinnitus definition, but was stronger with more bothersome tinnitus. With chronic pain, the odds of tinnitus >5 minutes was 64% higher, while odds of at least weekly, highly bothersome tinnitus was 144% higher than without chronic pain. Among participants with chronic pain, the number of pain regions was the pain variable most strongly associated with tinnitus >5 minutes (OR = 1.17 (95% CI: 1.14–1.20) for an increase of one region), whereas the other pain variables (intensity and bothering) showed weaker associations. All chronic pain variables had significant interactions with age, with the strongest associations for the youngest individuals (40–54 years). Our findings support the existence of an association between chronic pain and tinnitus and emphasises the importance of examining for comorbid pain in tinnitus patients to provide a more comprehensive treatment of tinnitus.


Author(s):  
Eric Newman ◽  
Eric Moulton ◽  
Lino Becerra ◽  
David Borsook
Keyword(s):  

2005 ◽  
Vol 13 (3) ◽  
pp. 258-265 ◽  
Author(s):  
Saxby Pridmore ◽  
Gajinder Oberoi ◽  
Marco Marcolin ◽  
Mark George

Objective: To examine evidence suggesting a potential role for transcranial magnetic stimulation (TMS) in the treatment of chronic pain. Conclusion: Chronic pain is characterized by brain changes that can reasonably be presumed to be associated with hyperalgesia, as occurs with neuropathic changes in the periphery. TMS has the ability to induce plastic changes in the cortex at the site of stimulation and at connected sites, including the spinal cord. It also has the ability to influence the experience of experimental/acute pain. In studies of TMS in chronic pain, there is some evidence that temporary relief can be achieved in a proportion of sufferers. Chronic pain is common. Current treatments are often ineffective and complicated by side-effects. Work to this point is encouraging, but systematic assessment of stimulation parameters is necessary if TMS is to achieve a role in the treatment of chronic pain. Maintenance TMS is currently provided in relapsing major depression and may be a useful model in chronic pain management.


PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e54475 ◽  
Author(s):  
Rea Rodriguez-Raecke ◽  
Andreas Niemeier ◽  
Kristin Ihle ◽  
Wolfgang Ruether ◽  
Arne May

Pancreas ◽  
2018 ◽  
Vol 47 (10) ◽  
pp. 1267-1276 ◽  
Author(s):  
Janusiya Muthulingam ◽  
Søren Schou Olesen ◽  
Tine Maria Hansen ◽  
David A. Seminowicz ◽  
Shana Burrowes ◽  
...  

2017 ◽  
Vol 21 (5) ◽  
pp. 769-786 ◽  
Author(s):  
A. Malfliet ◽  
I. Coppieters ◽  
P. Van Wilgen ◽  
J. Kregel ◽  
R. De Pauw ◽  
...  

2000 ◽  
Vol 27 (10) ◽  
pp. 834-841 ◽  
Author(s):  
O. Plesh ◽  
D. Curtis ◽  
J. Levine ◽  
W. D. Mccall Jr

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