Atorvastatin ameliorates depressive behaviors via regulation of α7nAChR expression by PI3K/Akt-BDNF pathway in mice

Author(s):  
Chao Yang ◽  
Huan-Yu Ni ◽  
Jia-Jie Yin ◽  
Ting Zhou ◽  
Qiu-Xiang Gu ◽  
...  
Keyword(s):  
2018 ◽  
Vol Volume 14 ◽  
pp. 3121-3132 ◽  
Author(s):  
Chenmeng Li ◽  
Xiaoyan Xu ◽  
Xiong Zhang ◽  
Ke Cheng ◽  
Yujie Guo ◽  
...  

Brain Injury ◽  
2018 ◽  
Vol 32 (13-14) ◽  
pp. 1858-1865 ◽  
Author(s):  
Weijie Wang ◽  
Mingyang Shen ◽  
Kun Sun ◽  
Yanping Wang ◽  
Xiaodong Wang ◽  
...  

2018 ◽  
Vol 14 (2) ◽  
pp. 164-178 ◽  
Author(s):  
Shao- Heng Li ◽  
Li-Tong Wang ◽  
Xue Deng ◽  
Ya- NanJiao ◽  
Liang Kong ◽  
...  

2018 ◽  
Vol 9 ◽  
Author(s):  
Xiaoning Tan ◽  
Xiaoxue Du ◽  
Yuting Jiang ◽  
Benson O. A. Botchway ◽  
Zhiying Hu ◽  
...  

2019 ◽  
Vol 12 ◽  
Author(s):  
Chunlei Yang ◽  
Tong Li ◽  
Hao Xue ◽  
Lingxiao Wang ◽  
Lin Deng ◽  
...  
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2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
A Young Min ◽  
Jae-Myung Yoo ◽  
Dai-Eun Sok ◽  
Mee Ree Kim

Although mulberry fruit has various beneficial effects, its effect on diabetes-related dementia remains unknown. We investigated whether the ethyl acetate fraction of ethanolic extract of mulberry fruit (MFE) could alleviate biochemical and behavioral deficits in alloxan-induced diabetic mice. In the diabetic mice, MFE considerably abolished multiple deficits, e.g., body weight reduction; water and food intake increase; and hyperglycemia, hyperlipidemia, hypoinsulinism, and hypertrophy of the liver, kidneys, spleen, and brain. A 200 mg/kg MFE dose reduced malondialdehyde levels and improved antioxidant enzyme activity in the liver, kidney, and brain tissues. MFE attenuated hyperglycemia-induced memory impairments and acetylcholine deprivation, protected neuronal cells in CA1 and CA3 regions via p-CREB/BDNF pathway activation, and reduced amyloid-β precursor protein and p-Tau expressions in the brain tissue. In conclusion, MFE exerts antidiabetic and neuroprotective effects by upregulating antioxidative activities and p-CREB/BDNF pathway in chronic diabetes. Therefore, MFE may be used as a therapeutic agent for diabetes and diabetic neurodegenerative diseases.


2019 ◽  
Vol 41 (7) ◽  
pp. 658-664 ◽  
Author(s):  
Weiliang He ◽  
Xiaochao Tian ◽  
Bilin Yuan ◽  
Bao Chu ◽  
Fan Gao ◽  
...  

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