Long non-coding RNAs in gastrointestinal cancers: implications for protein phosphorylation

2022 ◽  
pp. 114907
Author(s):  
Tao Su ◽  
Teng Wang ◽  
Nasha Zhang ◽  
Yue Shen ◽  
Wenwen Li ◽  
...  
Keyword(s):  
Protein Phosphorylation ◽  
Gastrointestinal Cancers ◽  
Non Coding Rnas

Protein-coding genes combined with long non-coding RNAs predict prognosis in esophageal squamous cell carcinoma patients as a novel clinical multi-dimensional signature

2016 ◽  
Vol 12 (11) ◽  
pp. 3467-3477 ◽  
Author(s):  
Jin-Cheng Guo ◽  
Chun-Quan Li ◽  
Qiu-Yu Wang ◽  
Jian-Mei Zhao ◽  
Ji-Yu Ding ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Mortality Rate ◽  
Esophageal Squamous Cell Carcinoma ◽  
Esophageal Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Gastrointestinal Cancers ◽  
Protein Coding ◽  
Protein Coding Genes ◽  
Non Coding Rnas

Esophageal carcinoma is one of the most malignant gastrointestinal cancers worldwide, and has a high mortality rate.

scholarly journals The Emerging Landscape of Long Non-Coding RNAs in Colorectal Cancer Metastasis

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhiming Liao ◽  
Hui Nie ◽  
Yutong Wang ◽  
Jingjing Luo ◽  
Jianhua Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Molecular Markers ◽  
Cancer Metastasis ◽  
Gastrointestinal Cancers ◽  
Malignant Phenotype ◽  
Rna Molecules ◽  
Non Coding Rna ◽  
Colorectal Cancer Metastasis ◽  
Non Coding Rnas ◽  
Patient Prognosis

Colorectal cancer (CRC) is one of the most common gastrointestinal cancers, with extremely high rates of morbidity and mortality. The main cause of death in CRC is distant metastasis; it affects patient prognosis and survival and is one of the key challenges in the treatment of CRC. Long non-coding RNAs (lncRNAs) are a group of non-coding RNA molecules with more than 200 nucleotides. Abnormal lncRNA expression is closely related to the occurrence and progression of several diseases, including cancer. Recent studies have shown that numerous lncRNAs play pivotal roles in the CRC metastasis, and reversing the expression of these lncRNAs through artificial means can reduce the malignant phenotype of metastatic CRC to some extent. This review summarizes the major mechanisms of lncRNAs in CRC metastasis and proposes lncRNAs as potential therapeutic targets for CRC and molecular markers for early diagnosis.

scholarly journals Methyladenosine Modification in RNAs: Classification and Roles in Gastrointestinal Cancers

2021 ◽  
Vol 10 ◽  
Author(s):  
Qinghai Li ◽  
Weiling He ◽  
Guohui Wan
Keyword(s):  
Molecular Mechanisms ◽  
Treatment Strategies ◽  
Messenger Rnas ◽  
Epigenetic Changes ◽  
Gastrointestinal Cancers ◽  
Ribonucleic Acids ◽  
Rna Methylation ◽  
Novel Treatment ◽  
Non Coding Rnas ◽  
Novel Treatment Strategies

Cellular ribonucleic acids (RNAs), including messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs), harbor more than 150 forms of chemical modifications, among which methylation modifications are dynamically regulated and play significant roles in RNA metabolism. Recently, dysregulation of RNA methylation modifications is found to be linked to various physiological bioprocesses and many human diseases. Gastric cancer (GC) and colorectal cancer (CRC) are two main gastrointestinal-related cancers (GIC) and the most leading causes of cancer-related death worldwide. In-depth understanding of molecular mechanisms on GIC can provide important insights in developing novel treatment strategies for GICs. In this review, we focus on the multitude of epigenetic changes of RNA methlyadenosine modifications in gene expression, and their roles in GIC tumorigenesis, progression, and drug resistance, and aim to provide the potential therapeutic regimens for GICs.

scholarly journals The role of non-coding RNAs in chemotherapy for gastrointestinal cancers

2021 ◽  
Author(s):  
Fatemeh Dashti ◽  
Seyed Mohammad Ali Mirazimi ◽  
Nikta Rabiei ◽  
Reza Fathazam ◽  
Negin Rabiei ◽  
...  
Keyword(s):  
Gastrointestinal Cancers ◽  
Non Coding Rnas

Involvement of protein phosphorylation in the sensitivity of photosystem II to strong illumination

1994 ◽  
Vol 92 (1) ◽  
pp. 181-187
Author(s):  
Maria T. Giardi ◽  
Josef Komenda ◽  
Jiri Masojidek
Keyword(s):  
Photosystem Ii ◽  
Protein Phosphorylation

ASCO-GI 2019: Gallengangskarzinome

2019 ◽  
Vol 10 (02) ◽  
pp. 67-67
Author(s):  
Alexander Kretzschmar
Keyword(s):  
Los Angeles ◽  
Phase Ii ◽  
Gastrointestinal Cancers

Gallengangskarzinome treten selten auf und weisen eine sehr schlechte Prognose auf. In einer auf dem Gastrointestinal Cancers Symposium (GICS) vorgestellten offenen Phase-II-Studie führte die Kombination der BRAF- and MEK-Inhibitoren Dabrafenib und Trametinib zu einer objektiven Responserate (ORR) als primärem Endpunkt von 41 % (13/32; 95 % Konfidenzintervall [KI] 24–59 %), so Prof. Zev A. Wainberg, Los Angeles/USA.

ASCO-GI 2019: Pankreaskarzinom

2019 ◽  
Vol 10 (02) ◽  
pp. 60-61
Author(s):  
Ine Schmale
Keyword(s):  
Gastrointestinal Cancers

Während bei vielen Tumorentitäten große Fortschritte in der Behandlung zu berichten sind, bleibt das Pankreaskarzinom ein Tumor mit einer schlechten Prognose und wenigen Therapieoptionen. Beim Gastrointestinal Cancers Symposium (ASCO­GI) wurde eine Sitzung der frühen Detektion, der Sequenztherapie resektabler Tumoren und den Therapien der Zukunft beim Pankreaskarzinom gewidmet.

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