Autologous bone marrow cells implantation induces bone formation in a sheep spinal fusion model

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S154
Author(s):  
Y. Qian ◽  
Z. Lin ◽  
J. Chen ◽  
Y. Fan ◽  
T. Davey ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Spinal Fusion ◽  
Bone Marrow Cells ◽  
Autologous Bone Marrow ◽  
Fusion Model ◽  
Autologous Bone ◽  
Marrow Cells

Development of cell therapy using autologous bone marrow cells for liver cirrhosis

2005 ◽  
Vol 38 (4) ◽  
pp. 197-202 ◽  
Author(s):  
Isao Sakaida ◽  
Shuji Terai ◽  
Hiroshi Nishina ◽  
Kiwamu Okita
Keyword(s):  
Bone Marrow ◽  
Liver Cirrhosis ◽  
Cell Therapy ◽  
Bone Marrow Cells ◽  
Autologous Bone Marrow ◽  
Autologous Bone ◽  
Marrow Cells

scholarly journals Prevention of corticosteroid-induced osteonecrosis in rabbits by intra-bone marrow injection of autologous bone marrow cells

Rheumatology ◽  
2008 ◽  
Vol 47 (5) ◽  
pp. 591-596 ◽  
Author(s):  
T. Asada ◽  
T. Kushida ◽  
M. Umeda ◽  
K. Oe ◽  
H. Matsuya ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Autologous Bone Marrow ◽  
Autologous Bone ◽  
Marrow Cells

Variability in 4-hydroperoxycyclophosphamide activity during clinical purging for autologous bone marrow transplantation

Blood ◽  
1987 ◽  
Vol 70 (5) ◽  
pp. 1490-1494 ◽  
Author(s):  
RJ Jones ◽  
M Zuehlsdorf ◽  
SD Rowley ◽  
J Hilton ◽  
GW Santos ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Bone Marrow Cells ◽  
Autologous Bone Marrow Transplantation ◽  
Tumor Cell Line ◽  
Autologous Bone Marrow ◽  
Incubation Mixture ◽  
Autologous Bone ◽  
Marrow Cells

Abstract We examined the effects of varying incubation conditions on the in vitro activity of 4-hydroperoxycyclophosphamide (4HC). 4HC activity against CFU-GM and against the K562 tumor cell line decreased with increasing the RBC concentration of the incubation mixture. Increasing the concentration of nucleated bone marrow cells in the incubation mixture also decreased the 4HC activity. Evaluation of 53 consecutive patients undergoing autologous bone marrow transplantation (BMT) revealed that the incubation RBC concentration during clinical purging showed a similar effect on CFU-GM recovery. Aldehyde dehydrogenase content of RBCs and nucleated marrow cells appears to be the cause of the inhibition of 4HC activity. Although there was no difference in individual CFU-GM sensitivity to 4HC among normals, previously treated patients undergoing autologous BMT showed significant variability in CFU-GM sensitivity to 4HC. The combined effects of incubation RBC concentration and individual patient 4HC sensitivity appear to account for most of the variability in CFU-GM recovery and speed of hematologic recovery after clinical purging with 4HC.

scholarly journals Refractory Angina Cell Therapy (ReACT) Involving Autologous Bone Marrow Cells in Patients without Left Ventricular Dysfunction: A Possible Role for Monocytes

2009 ◽  
Vol 18 (12) ◽  
pp. 1299-1310 ◽  
Author(s):  
Nelson Americo Hossne ◽  
Adriana Luckow Invitti ◽  
Enio Buffolo ◽  
Silvia Azevedo ◽  
Jose Salvador Rodrigues de Oliveira ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Therapy ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Bone Marrow Cells ◽  
Autologous Bone Marrow ◽  
Left Ventricular ◽  
Refractory Angina ◽  
Autologous Bone ◽  
Marrow Cells

Autologous Bone Marrow Cells for Treatment of Myocardial Infarction in Colombia.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 4171-4171
Author(s):  
Francisco Cuéllar-Ambrosi ◽  
Juán Manuel ◽  
Oscar Velásquez ◽  
Margarita Velásquez-Lopera ◽  
Claudia Navas ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Bone Marrow ◽  
Heart Disease ◽  
Bone Marrow Cells ◽  
Autologous Bone Marrow ◽  
Acute Mi ◽  
Autologous Bone ◽  
Stimulating Factor ◽  
Marrow Cells

Abstract Experimental studies in animals demonstrate the ability of the bone marrow stem cells to differentiate in cardiomyocytes, vascular endothelium cells and smooth muscle cells. There is evidence that these cells can regenerate infarcted myocardium and induce myogenesis and angiogenesis. Clinical studies in humans suggest the feasibility and safety of the utilization of the stem cells to recovery the ventricular function in patients with acute myocardial infarction. We report the first experience in Colombia using autologous bone marrow cells for cardiomyoplasty in isquemic heart disease. This report shows the two months follow-up of four patients, three with acute myocardial infarction of the anterior myocardial wall and one patient with severe chronic isquemic heart disease. Extensive myocardial damage demonstrated by absence of viability in scintigraphic images and ejection fraction less than 40%. The patients received an optimum postinfarction medical treatment, successful coronary percutaneous intervention (three patients) or direct intramyocardial injection (one patient) to transfer of autologous bone marrow cells mobilised with granulocyte-colony stimulating factor during five days. Demographics and results The exercise capacity improve importantly, evidenced by increase in contractility, the six minutes test, the treadmill exercise time and the functional capacity in METS. There were not changes in the myocardial perfusion at two months follow-up, there were not complications related to the cellular transplant or the utilization of the granulocyte-colony stimulating factor. This is the first experience in Colombia with the bone marrow cells and selective intracoronary transplantation for myocardial regeneration and angiogenesis. We observed functional recovery of the left ventricle, improvement in the exercise capacity without adverse effects or complications related to the therapy. Patient # 1 2 3 4 MI= myocardial infarction, IHD= isquemic heart disease, B/A= before/after 2 months, EF= eyection fraction, ESV=end systolic volume Age/sex 51/M 23/M 59/M 53/M Diagnosis acute MI acute MI acute MI chronic IHD Diagnosis to transplant 3 weeks 2 weeks 4 weeks > 1 year CD34 dose 19.7x10(6) 16.8x10(6) 19.5x10(6) 21.7x10(6) EF% B/A 36/43 26/40 40/41 45/55 ESV (cc) B/A 80/60 116/103 65/70 101/84 METS B/A 4/14 4/17 5/12 5/14 6-min test (mts) B/A 420/540 216/462 260/450 414/727

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